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Vitamin E protects neurons against oxidative cell death in vitro more effectively than 17-beta estradiol and induces the activity of the transcription factor NF-kappaB.
J Neural Transm (Vienna). 2000; 107(4):393-407.JN

Abstract

Antioxidants can function as powerful protectants for neurons in vitro. Here, the neuroprotective activity of lipophilic free radical scavengers synthetic (+/-) alpha-tocopherol (synthetic vitamin E) and natural (+) alpha-tocopherol (natural vitamin E) against oxidative stress was investigated and compared to the neuroprotective effect of the female sex hormone estradiol. Employing mouse clonal hippocampal HT22 cells and rat cerebellar granule neurons, we found that both types of alpha-tocopherol exerted a higher neuroprotective antioxidant activity than 17-beta estradiol. At concentrations as low as 100 nM, synthetic (+/-) alpha-tocopherol and natural (+) alpha-tocopherol protected neurons effectively against the oxidative cell death caused by the Alzheimer's disease-associated amyloid beta protein, hydrogen peroxide, and the excitatory amino acid glutamate. Moreover, vitamin E induced the activity of the redox-sensitive transcription factor NF-kappaB, which is involved in the control of nerve cell survival and, therefore, may play also a role in vitamin E-induced neuroprotection. These results may have implications regarding the prevention and treatment of oxidative stress-related degenerative disorders such as Alzheimer's disease.

Authors+Show Affiliations

Independent Research Group Neurodegeneration, Max Planck Institute of Psychiatry, Munich, Federal Republic of Germany. chris@mpipsykl.mpg.de

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11215751

Citation

Behl, C. "Vitamin E Protects Neurons Against Oxidative Cell Death in Vitro More Effectively Than 17-beta Estradiol and Induces the Activity of the Transcription Factor NF-kappaB." Journal of Neural Transmission (Vienna, Austria : 1996), vol. 107, no. 4, 2000, pp. 393-407.
Behl C. Vitamin E protects neurons against oxidative cell death in vitro more effectively than 17-beta estradiol and induces the activity of the transcription factor NF-kappaB. J Neural Transm (Vienna). 2000;107(4):393-407.
Behl, C. (2000). Vitamin E protects neurons against oxidative cell death in vitro more effectively than 17-beta estradiol and induces the activity of the transcription factor NF-kappaB. Journal of Neural Transmission (Vienna, Austria : 1996), 107(4), 393-407.
Behl C. Vitamin E Protects Neurons Against Oxidative Cell Death in Vitro More Effectively Than 17-beta Estradiol and Induces the Activity of the Transcription Factor NF-kappaB. J Neural Transm (Vienna). 2000;107(4):393-407. PubMed PMID: 11215751.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin E protects neurons against oxidative cell death in vitro more effectively than 17-beta estradiol and induces the activity of the transcription factor NF-kappaB. A1 - Behl,C, PY - 2001/2/24/pubmed PY - 2001/5/22/medline PY - 2001/2/24/entrez SP - 393 EP - 407 JF - Journal of neural transmission (Vienna, Austria : 1996) JO - J Neural Transm (Vienna) VL - 107 IS - 4 N2 - Antioxidants can function as powerful protectants for neurons in vitro. Here, the neuroprotective activity of lipophilic free radical scavengers synthetic (+/-) alpha-tocopherol (synthetic vitamin E) and natural (+) alpha-tocopherol (natural vitamin E) against oxidative stress was investigated and compared to the neuroprotective effect of the female sex hormone estradiol. Employing mouse clonal hippocampal HT22 cells and rat cerebellar granule neurons, we found that both types of alpha-tocopherol exerted a higher neuroprotective antioxidant activity than 17-beta estradiol. At concentrations as low as 100 nM, synthetic (+/-) alpha-tocopherol and natural (+) alpha-tocopherol protected neurons effectively against the oxidative cell death caused by the Alzheimer's disease-associated amyloid beta protein, hydrogen peroxide, and the excitatory amino acid glutamate. Moreover, vitamin E induced the activity of the redox-sensitive transcription factor NF-kappaB, which is involved in the control of nerve cell survival and, therefore, may play also a role in vitamin E-induced neuroprotection. These results may have implications regarding the prevention and treatment of oxidative stress-related degenerative disorders such as Alzheimer's disease. SN - 0300-9564 UR - https://www.unboundmedicine.com/medline/citation/11215751/Vitamin_E_protects_neurons_against_oxidative_cell_death_in_vitro_more_effectively_than_17_beta_estradiol_and_induces_the_activity_of_the_transcription_factor_NF_kappaB_ L2 - https://doi.org/10.1007/s007020070082 DB - PRIME DP - Unbound Medicine ER -