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Causes of Alzheimer's disease.
CMAJ 2000; 162(1):65-72CMAJ

Abstract

It is now understood that genetic factors play a crucial role in the risk of developing Alzheimer's disease (AD). Rare mutations in at least 3 genes are responsible for early-onset familial AD. A common polymorphism in the apolipoprotein E gene is the major determinant of risk in families with late-onset AD, as well as in the general population. Advanced age, however, remains the major established risk factor for AD, although environmental variables may also have some role in disease expression. Some pathogenic factors directly associated with aging include oxidative damage and mutations in messenger RNA. Other factors unrelated to the aging process may, in the future, be amenable to therapeutic intervention by way of estrogen replacement therapy for postmenopausal women, anti-inflammatory drug therapy and reducing vascular risk factors. Older theories, such as aluminum playing a role in the pathogenesis of AD, have been mostly discarded as our understanding of pathogenic mechanisms of AD has advanced.

Authors+Show Affiliations

Department of Pathology, University of Western Ontario, London, Ont.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

11216203

Citation

Munoz, D G., and H Feldman. "Causes of Alzheimer's Disease." CMAJ : Canadian Medical Association Journal = Journal De l'Association Medicale Canadienne, vol. 162, no. 1, 2000, pp. 65-72.
Munoz DG, Feldman H. Causes of Alzheimer's disease. CMAJ. 2000;162(1):65-72.
Munoz, D. G., & Feldman, H. (2000). Causes of Alzheimer's disease. CMAJ : Canadian Medical Association Journal = Journal De l'Association Medicale Canadienne, 162(1), pp. 65-72.
Munoz DG, Feldman H. Causes of Alzheimer's Disease. CMAJ. 2000 Jan 11;162(1):65-72. PubMed PMID: 11216203.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Causes of Alzheimer's disease. AU - Munoz,D G, AU - Feldman,H, PY - 2001/2/24/pubmed PY - 2001/3/7/medline PY - 2001/2/24/entrez SP - 65 EP - 72 JF - CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne JO - CMAJ VL - 162 IS - 1 N2 - It is now understood that genetic factors play a crucial role in the risk of developing Alzheimer's disease (AD). Rare mutations in at least 3 genes are responsible for early-onset familial AD. A common polymorphism in the apolipoprotein E gene is the major determinant of risk in families with late-onset AD, as well as in the general population. Advanced age, however, remains the major established risk factor for AD, although environmental variables may also have some role in disease expression. Some pathogenic factors directly associated with aging include oxidative damage and mutations in messenger RNA. Other factors unrelated to the aging process may, in the future, be amenable to therapeutic intervention by way of estrogen replacement therapy for postmenopausal women, anti-inflammatory drug therapy and reducing vascular risk factors. Older theories, such as aluminum playing a role in the pathogenesis of AD, have been mostly discarded as our understanding of pathogenic mechanisms of AD has advanced. SN - 0820-3946 UR - https://www.unboundmedicine.com/medline/citation/11216203/Causes_of_Alzheimer's_disease_ L2 - http://www.cmaj.ca/cgi/pmidlookup?view=long&pmid=11216203 DB - PRIME DP - Unbound Medicine ER -