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[A case of Ondine curse associated with a medullary tumor].
Rinsho Shinkeigaku. 2000 Aug; 40(8):811-5.RS

Abstract

A 49-year-old woman with 6 months history of body weight loss, muscle weakness, and dysarthria, was found with respiratory arrest and resuscitated in the morning of January 1999. An MRI brain scan revealed diffuse swelling and T2/FLAIR high signal intensity with mild Gadolinium enhancement in the lower pons and medulla oblongata. Although the histological diagnosis could not be obtained, glioma (astrocytoma) was suspected. In the morning of July 3rd she presented sweating and cyanosis. Her arterial oxygen saturation was 18%. When we asked her to breathe more, she kept breathing and oxygen saturation was normalized. However, she could not breathe at all when she fell asleep without stimulation. She was kept under respiratory support for 2 months. Her symptoms improved with fluctuating course after 70 Gy of radiation therapy. Ondine curse is one type of sleep apnea syndrome, defined as the selective disturbance of autonomous breathing. Surgical operation and stroke are the reported causes of this syndrome. Brainstem tumor is relatively common cause for children's Ondine curse. On the other hand, it rarely causes adult's Ondine curse as a main symptom.

Authors+Show Affiliations

Nakajima M
Department of Neurology, Kumamoto City Hospital.
Katsura K
No affiliation info available
Hashimoto Y
No affiliation info available
Terasaki T
No affiliation info available
Uchino M
No affiliation info available

MeSH

AstrocytomaBrain Stem NeoplasmsFemaleHumansMagnetic Resonance ImagingMiddle AgedSleep Apnea, Central

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

jpn

PubMed ID

11218702

Citation

Nakajima, M, et al. "[A Case of Ondine Curse Associated With a Medullary Tumor]." Rinsho Shinkeigaku = Clinical Neurology, vol. 40, no. 8, 2000, pp. 811-5.
Nakajima M, Katsura K, Hashimoto Y, et al. [A case of Ondine curse associated with a medullary tumor]. Rinsho Shinkeigaku. 2000;40(8):811-5.
Nakajima, M., Katsura, K., Hashimoto, Y., Terasaki, T., & Uchino, M. (2000). [A case of Ondine curse associated with a medullary tumor]. Rinsho Shinkeigaku = Clinical Neurology, 40(8), 811-5.
Nakajima M, et al. [A Case of Ondine Curse Associated With a Medullary Tumor]. Rinsho Shinkeigaku. 2000;40(8):811-5. PubMed PMID: 11218702.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [A case of Ondine curse associated with a medullary tumor]. AU - Nakajima,M, AU - Katsura,K, AU - Hashimoto,Y, AU - Terasaki,T, AU - Uchino,M, PY - 2001/2/24/pubmed PY - 2001/4/21/medline PY - 2001/2/24/entrez SP - 811 EP - 5 JF - Rinsho shinkeigaku = Clinical neurology JO - Rinsho Shinkeigaku VL - 40 IS - 8 N2 - A 49-year-old woman with 6 months history of body weight loss, muscle weakness, and dysarthria, was found with respiratory arrest and resuscitated in the morning of January 1999. An MRI brain scan revealed diffuse swelling and T2/FLAIR high signal intensity with mild Gadolinium enhancement in the lower pons and medulla oblongata. Although the histological diagnosis could not be obtained, glioma (astrocytoma) was suspected. In the morning of July 3rd she presented sweating and cyanosis. Her arterial oxygen saturation was 18%. When we asked her to breathe more, she kept breathing and oxygen saturation was normalized. However, she could not breathe at all when she fell asleep without stimulation. She was kept under respiratory support for 2 months. Her symptoms improved with fluctuating course after 70 Gy of radiation therapy. Ondine curse is one type of sleep apnea syndrome, defined as the selective disturbance of autonomous breathing. Surgical operation and stroke are the reported causes of this syndrome. Brainstem tumor is relatively common cause for children's Ondine curse. On the other hand, it rarely causes adult's Ondine curse as a main symptom. SN - 0009-918X UR - https://www.unboundmedicine.com/medline/citation/11218702/[A_case_of_Ondine_curse_associated_with_a_medullary_tumor]_ DB - PRIME DP - Unbound Medicine ER -