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Dexamethasone prophylaxis of nausea and vomiting after epidural morphine for post-Cesarean analgesia.
Can J Anaesth. 2001 Feb; 48(2):185-90.CJ

Abstract

PURPOSE

To determine the minimum effective dose of dexamethasone in preventing nausea and vomiting associated with epidural morphine for post-Cesarean analgesia.

METHOD

One hundred and eighty parturients (n=45 in each of four groups) requiring epidural morphine for post-Cesarean analgesia were enrolled in this randomized, double-blinded, placebo-controlled study. At the end of surgery, parturients received either dexamethasone, at doses of 10 mg, 5 mg, 2.5 mg, or saline i.v.. Three milligrams epidural morphine were given to all parturients for postoperative analgesia. The incidence of PONV and side effects were estimated for 24 hr after delivery by blinded, trained nurse anesthetists.

RESULTS

Parturients who received dexamethasone, either 10 mg or 5 mg were different from those who received saline alone in the following parameters: the total incidence of nausea and vomiting, incidence of > 4 vomiting episodes, number the of parturients requiring rescue antiemetics, and the total number of parturients with no vomiting and/or no antiemetic medication (P < 0.05 to P < 0.01). The differences between dexamethasone 10 mg and 5 mg were not significant. Dexamethasone 2.5 mg was partially effective.

CONCLUSION

Dexamethasone, 5 mg i.v., is suggested as the minimum effective dose in preventing nausea and vomiting associated with epidural morphine for post-Cesarean analgesia.

Authors+Show Affiliations

Wang JJ
Department of Anesthesiology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. painlab@tpts5.seed.net.tw
Ho ST
No affiliation info available
Wong CS
No affiliation info available
Tzeng JI
No affiliation info available
Liu HS
No affiliation info available
Ger LP
No affiliation info available

MeSH

AdultAnalgesia, EpiduralAnalgesics, OpioidAntiemeticsCesarean SectionDexamethasoneDouble-Blind MethodFemaleHumansMorphinePain MeasurementPain, PostoperativePostoperative Nausea and VomitingPregnancy

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

11220429

Citation

Wang, J J., et al. "Dexamethasone Prophylaxis of Nausea and Vomiting After Epidural Morphine for post-Cesarean Analgesia." Canadian Journal of Anaesthesia = Journal Canadien D'anesthesie, vol. 48, no. 2, 2001, pp. 185-90.
Wang JJ, Ho ST, Wong CS, et al. Dexamethasone prophylaxis of nausea and vomiting after epidural morphine for post-Cesarean analgesia. Can J Anaesth. 2001;48(2):185-90.
Wang, J. J., Ho, S. T., Wong, C. S., Tzeng, J. I., Liu, H. S., & Ger, L. P. (2001). Dexamethasone prophylaxis of nausea and vomiting after epidural morphine for post-Cesarean analgesia. Canadian Journal of Anaesthesia = Journal Canadien D'anesthesie, 48(2), 185-90.
Wang JJ, et al. Dexamethasone Prophylaxis of Nausea and Vomiting After Epidural Morphine for post-Cesarean Analgesia. Can J Anaesth. 2001;48(2):185-90. PubMed PMID: 11220429.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dexamethasone prophylaxis of nausea and vomiting after epidural morphine for post-Cesarean analgesia. AU - Wang,J J, AU - Ho,S T, AU - Wong,C S, AU - Tzeng,J I, AU - Liu,H S, AU - Ger,L P, PY - 2001/2/28/pubmed PY - 2001/5/22/medline PY - 2001/2/28/entrez SP - 185 EP - 90 JF - Canadian journal of anaesthesia = Journal canadien d'anesthesie JO - Can J Anaesth VL - 48 IS - 2 N2 - PURPOSE: To determine the minimum effective dose of dexamethasone in preventing nausea and vomiting associated with epidural morphine for post-Cesarean analgesia. METHOD: One hundred and eighty parturients (n=45 in each of four groups) requiring epidural morphine for post-Cesarean analgesia were enrolled in this randomized, double-blinded, placebo-controlled study. At the end of surgery, parturients received either dexamethasone, at doses of 10 mg, 5 mg, 2.5 mg, or saline i.v.. Three milligrams epidural morphine were given to all parturients for postoperative analgesia. The incidence of PONV and side effects were estimated for 24 hr after delivery by blinded, trained nurse anesthetists. RESULTS: Parturients who received dexamethasone, either 10 mg or 5 mg were different from those who received saline alone in the following parameters: the total incidence of nausea and vomiting, incidence of > 4 vomiting episodes, number the of parturients requiring rescue antiemetics, and the total number of parturients with no vomiting and/or no antiemetic medication (P < 0.05 to P < 0.01). The differences between dexamethasone 10 mg and 5 mg were not significant. Dexamethasone 2.5 mg was partially effective. CONCLUSION: Dexamethasone, 5 mg i.v., is suggested as the minimum effective dose in preventing nausea and vomiting associated with epidural morphine for post-Cesarean analgesia. SN - 0832-610X UR - https://www.unboundmedicine.com/medline/citation/11220429/Dexamethasone_prophylaxis_of_nausea_and_vomiting_after_epidural_morphine_for_post_Cesarean_analgesia_ DB - PRIME DP - Unbound Medicine ER -