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Sildenafil citrate (Viagra) is effective and well tolerated for treating erectile dysfunction of psychogenic or mixed aetiology.
Int J Clin Pract. 2000 Nov; 54(9):561-6.IJ

Abstract

Sildenafil citrate (Viagra) has been shown to be an effective treatment for erectile dysfunction (ED) of organic aetiology. This study assessed the efficacy and tolerability of sildenafil for treating ED of psychogenic and mixed psychogenic/organic aetiology. Men with ED of psychogenic and mixed aetiology were randomised in a double-blind, fixed-dose study to placebo (n = 95) or sildenafil 10 mg (n = 90), 25 mg (n = 85), or 50 mg (n = 81) once daily for 28 days. Efficacy was evaluated with two global efficacy questions, a patient log of erectile activity, a sexual function questionnaire and a partner questionnaire. Patients receiving sildenafil had significantly more grade 3 (hard enough for penetration) or grade 4 (fully hard) erections per week than patients receiving placebo, and a greater proportion of patients receiving sildenafil reported that treatment had improved their erections (p < 0.001). Results of the sexual function questionnaire demonstrated significant improvement for patients with ED receiving sildenafil compared with patients receiving placebo for frequency, hardness and duration of erections (p < 0.01), and for enjoyment of sexual intercourse and satisfaction with sex life (p < 0.05). The results of the partner questionnaire were consistent with the results reported by patients and showed that treatment with sildenafil was associated with significant improvement in the partners' own sex lives (p < 0.001). Adverse events were mostly mild to moderate in nature. The commonest adverse events were headache, dyspepsia, flushing, myalgia, arthralgia and flu syndrome. Discontinuations due to treatment-related adverse events were few, ranging from 1.1% to 6.2% for patients receiving different doses of sildenafil and 4.2% for patients receiving placebo. Sildenafil is an effective and well-tolerated treatment for ED of psychogenic or mixed aetiology with once-daily dosing.

Authors+Show Affiliations

Department of Urology, University Hospital, 221 85 Lund, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

11220982

Citation

Olsson, A M., et al. "Sildenafil Citrate (Viagra) Is Effective and Well Tolerated for Treating Erectile Dysfunction of Psychogenic or Mixed Aetiology." International Journal of Clinical Practice, vol. 54, no. 9, 2000, pp. 561-6.
Olsson AM, Speakman MJ, Dinsmore WW, et al. Sildenafil citrate (Viagra) is effective and well tolerated for treating erectile dysfunction of psychogenic or mixed aetiology. Int J Clin Pract. 2000;54(9):561-6.
Olsson, A. M., Speakman, M. J., Dinsmore, W. W., Giuliano, F., Gingell, C., Maytom, M., Smith, M. D., & Osterloh, I. (2000). Sildenafil citrate (Viagra) is effective and well tolerated for treating erectile dysfunction of psychogenic or mixed aetiology. International Journal of Clinical Practice, 54(9), 561-6.
Olsson AM, et al. Sildenafil Citrate (Viagra) Is Effective and Well Tolerated for Treating Erectile Dysfunction of Psychogenic or Mixed Aetiology. Int J Clin Pract. 2000;54(9):561-6. PubMed PMID: 11220982.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sildenafil citrate (Viagra) is effective and well tolerated for treating erectile dysfunction of psychogenic or mixed aetiology. AU - Olsson,A M, AU - Speakman,M J, AU - Dinsmore,W W, AU - Giuliano,F, AU - Gingell,C, AU - Maytom,M, AU - Smith,M D, AU - Osterloh,I, AU - ,, PY - 2001/2/28/pubmed PY - 2001/3/10/medline PY - 2001/2/28/entrez SP - 561 EP - 6 JF - International journal of clinical practice JO - Int J Clin Pract VL - 54 IS - 9 N2 - Sildenafil citrate (Viagra) has been shown to be an effective treatment for erectile dysfunction (ED) of organic aetiology. This study assessed the efficacy and tolerability of sildenafil for treating ED of psychogenic and mixed psychogenic/organic aetiology. Men with ED of psychogenic and mixed aetiology were randomised in a double-blind, fixed-dose study to placebo (n = 95) or sildenafil 10 mg (n = 90), 25 mg (n = 85), or 50 mg (n = 81) once daily for 28 days. Efficacy was evaluated with two global efficacy questions, a patient log of erectile activity, a sexual function questionnaire and a partner questionnaire. Patients receiving sildenafil had significantly more grade 3 (hard enough for penetration) or grade 4 (fully hard) erections per week than patients receiving placebo, and a greater proportion of patients receiving sildenafil reported that treatment had improved their erections (p < 0.001). Results of the sexual function questionnaire demonstrated significant improvement for patients with ED receiving sildenafil compared with patients receiving placebo for frequency, hardness and duration of erections (p < 0.01), and for enjoyment of sexual intercourse and satisfaction with sex life (p < 0.05). The results of the partner questionnaire were consistent with the results reported by patients and showed that treatment with sildenafil was associated with significant improvement in the partners' own sex lives (p < 0.001). Adverse events were mostly mild to moderate in nature. The commonest adverse events were headache, dyspepsia, flushing, myalgia, arthralgia and flu syndrome. Discontinuations due to treatment-related adverse events were few, ranging from 1.1% to 6.2% for patients receiving different doses of sildenafil and 4.2% for patients receiving placebo. Sildenafil is an effective and well-tolerated treatment for ED of psychogenic or mixed aetiology with once-daily dosing. SN - 1368-5031 UR - https://www.unboundmedicine.com/medline/citation/11220982/Sildenafil_citrate__Viagra__is_effective_and_well_tolerated_for_treating_erectile_dysfunction_of_psychogenic_or_mixed_aetiology_ L2 - http://www.diseaseinfosearch.org/result/9682 DB - PRIME DP - Unbound Medicine ER -