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Cross reactivity of different specific Micrurus antivenom sera with homologous and heterologous snake venoms.
Toxicon. 2001 Jul; 39(7):949-53.T

Abstract

Coral snakes are the only Elapids in America. They are represented by three genera: Leptomicrurus, Micruroides and Micrurus, of which the latter are the most abundant and diversified group. Little is known about the biochemistry of Micrurus venoms due to low availability. Here, we present a study on the cross reactivity of different specific Micrurus antivenom with homologous and heterologous snake venoms in order to contribute to the generation of more efficient antiserum for therapeutic purposes. The three specific antisera tested, anti-Micrurus corallinus, anti-Micrurus frontalis, and anti-Micrurus spixii, as well as the bivalent anti-elapid venom sera, raised against a mixture (50% each) of Micrurus frontalis and Micrurus corallinus venoms, were assayed by Western Blot against Micrurus and non-Micrurus elapid venoms. An antisera raised against a recombinant alpha-neurotoxin-like protein from Micrurus corallinus venom, only reacted in Western blot with its homologous venom, indicating that this protein is specific for Micrurus corallinus coral snake.

Authors+Show Affiliations

Centro de Biotecnologia, Instituto Butantan, 05503-900, SP, São Paulo, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11223083

Citation

Prieto da Silva, A R., et al. "Cross Reactivity of Different Specific Micrurus Antivenom Sera With Homologous and Heterologous Snake Venoms." Toxicon : Official Journal of the International Society On Toxinology, vol. 39, no. 7, 2001, pp. 949-53.
Prieto da Silva AR, Yamagushi IK, Morais JF, et al. Cross reactivity of different specific Micrurus antivenom sera with homologous and heterologous snake venoms. Toxicon. 2001;39(7):949-53.
Prieto da Silva, A. R., Yamagushi, I. K., Morais, J. F., Higashi, H. G., Raw, I., Ho, P. L., & Oliveira, J. S. (2001). Cross reactivity of different specific Micrurus antivenom sera with homologous and heterologous snake venoms. Toxicon : Official Journal of the International Society On Toxinology, 39(7), 949-53.
Prieto da Silva AR, et al. Cross Reactivity of Different Specific Micrurus Antivenom Sera With Homologous and Heterologous Snake Venoms. Toxicon. 2001;39(7):949-53. PubMed PMID: 11223083.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cross reactivity of different specific Micrurus antivenom sera with homologous and heterologous snake venoms. AU - Prieto da Silva,A R, AU - Yamagushi,I K, AU - Morais,J F, AU - Higashi,H G, AU - Raw,I, AU - Ho,P L, AU - Oliveira,J S, PY - 2001/2/27/pubmed PY - 2001/7/13/medline PY - 2001/2/27/entrez SP - 949 EP - 53 JF - Toxicon : official journal of the International Society on Toxinology JO - Toxicon VL - 39 IS - 7 N2 - Coral snakes are the only Elapids in America. They are represented by three genera: Leptomicrurus, Micruroides and Micrurus, of which the latter are the most abundant and diversified group. Little is known about the biochemistry of Micrurus venoms due to low availability. Here, we present a study on the cross reactivity of different specific Micrurus antivenom with homologous and heterologous snake venoms in order to contribute to the generation of more efficient antiserum for therapeutic purposes. The three specific antisera tested, anti-Micrurus corallinus, anti-Micrurus frontalis, and anti-Micrurus spixii, as well as the bivalent anti-elapid venom sera, raised against a mixture (50% each) of Micrurus frontalis and Micrurus corallinus venoms, were assayed by Western Blot against Micrurus and non-Micrurus elapid venoms. An antisera raised against a recombinant alpha-neurotoxin-like protein from Micrurus corallinus venom, only reacted in Western blot with its homologous venom, indicating that this protein is specific for Micrurus corallinus coral snake. SN - 0041-0101 UR - https://www.unboundmedicine.com/medline/citation/11223083/Cross_reactivity_of_different_specific_Micrurus_antivenom_sera_with_homologous_and_heterologous_snake_venoms_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0041010100002336 DB - PRIME DP - Unbound Medicine ER -