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Maternal serum leptin concentrations do not correlate with cord blood leptin concentrations in normal pregnancy.
J Soc Gynecol Investig. 2001 Jan-Feb; 8(1):43-7.JS

Abstract

OBJECTIVE

To determine whether there is a difference in maternal leptin concentration and cord blood concentration, consistent with the hypothesis of a noncommunicating, two-compartement model of fetoplacental leptin regulation.

METHODS

Blood samples were collected from 139 women, identified as having an uncomplicated pregnancy, from an antecubital vein at delivery. Cord blood samples were taken from the umbilical vein. Leptin was measured by radioimmunoassay, and its relationship to fetal and maternal anthropometrics was assessed by Spearman correlation. Differences in maternal and cord blood leptin levels between male and female infants were tested with the Mann-Whitney Utest. Maternal and cord blood leptin were compared by the Wilcoxon signed rank test. The outcome measures were maternal and cord blood leptin at delivery, fetal birth weight, length, weight/length ratio, and ponderal index, maternal prepregnancy body mass index, pregnancy weight gain, relative weight gain, and body mass index at delivery.

RESULTS

No correlations were found between maternal and cord blood leptin concentrations. Fetal leptin level correlated with birth weight (rho = 0.665; P <.0001), length (rho = 0.490; P <.0001), ponderal index (rho = 0.260; P =.002), and weight/length ratio (rho = 0.625; P <.0001). Median leptin concentrations were higher in female (9.3 ng/mL, range 1.5-34.4 ng/mL) than in male (8.2 ng/mL, range 1.6-38.3 ng/mL) neonates, but this difference was statistically not significant. Logistic regression analysis showed a significant influence on umbilical venous leptin concentration for birth weight (P <.0001) but not for gender. Maternal leptin concentrations were significantly higher than cord leptin concentrations (P <.0005 for the male and female neonates and the entire group).

CONCLUSION

There was no correlation between maternal and cord leptin, which supports the hypothesis of a noncommunicating, two-compartment model of fetoplacental leptin regulation.

Authors+Show Affiliations

University of Vienna Medical School, Department of Obstetrics and Gynecology, Division of Gynecology, Waehringer Guertel 18-20, A-1090 Vienna, Austria. thomas.laml@akh-wien.ac.atNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

11223357

Citation

Laml, T, et al. "Maternal Serum Leptin Concentrations Do Not Correlate With Cord Blood Leptin Concentrations in Normal Pregnancy." Journal of the Society for Gynecologic Investigation, vol. 8, no. 1, 2001, pp. 43-7.
Laml T, Hartmann BW, Ruecklinger E, et al. Maternal serum leptin concentrations do not correlate with cord blood leptin concentrations in normal pregnancy. J Soc Gynecol Investig. 2001;8(1):43-7.
Laml, T., Hartmann, B. W., Ruecklinger, E., Preyer, O., Soeregi, G., & Wagenbichler, P. (2001). Maternal serum leptin concentrations do not correlate with cord blood leptin concentrations in normal pregnancy. Journal of the Society for Gynecologic Investigation, 8(1), 43-7.
Laml T, et al. Maternal Serum Leptin Concentrations Do Not Correlate With Cord Blood Leptin Concentrations in Normal Pregnancy. J Soc Gynecol Investig. 2001 Jan-Feb;8(1):43-7. PubMed PMID: 11223357.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal serum leptin concentrations do not correlate with cord blood leptin concentrations in normal pregnancy. AU - Laml,T, AU - Hartmann,B W, AU - Ruecklinger,E, AU - Preyer,O, AU - Soeregi,G, AU - Wagenbichler,P, PY - 2001/2/27/pubmed PY - 2001/5/18/medline PY - 2001/2/27/entrez SP - 43 EP - 7 JF - Journal of the Society for Gynecologic Investigation JO - J. Soc. Gynecol. Investig. VL - 8 IS - 1 N2 - OBJECTIVE: To determine whether there is a difference in maternal leptin concentration and cord blood concentration, consistent with the hypothesis of a noncommunicating, two-compartement model of fetoplacental leptin regulation. METHODS: Blood samples were collected from 139 women, identified as having an uncomplicated pregnancy, from an antecubital vein at delivery. Cord blood samples were taken from the umbilical vein. Leptin was measured by radioimmunoassay, and its relationship to fetal and maternal anthropometrics was assessed by Spearman correlation. Differences in maternal and cord blood leptin levels between male and female infants were tested with the Mann-Whitney Utest. Maternal and cord blood leptin were compared by the Wilcoxon signed rank test. The outcome measures were maternal and cord blood leptin at delivery, fetal birth weight, length, weight/length ratio, and ponderal index, maternal prepregnancy body mass index, pregnancy weight gain, relative weight gain, and body mass index at delivery. RESULTS: No correlations were found between maternal and cord blood leptin concentrations. Fetal leptin level correlated with birth weight (rho = 0.665; P <.0001), length (rho = 0.490; P <.0001), ponderal index (rho = 0.260; P =.002), and weight/length ratio (rho = 0.625; P <.0001). Median leptin concentrations were higher in female (9.3 ng/mL, range 1.5-34.4 ng/mL) than in male (8.2 ng/mL, range 1.6-38.3 ng/mL) neonates, but this difference was statistically not significant. Logistic regression analysis showed a significant influence on umbilical venous leptin concentration for birth weight (P <.0001) but not for gender. Maternal leptin concentrations were significantly higher than cord leptin concentrations (P <.0005 for the male and female neonates and the entire group). CONCLUSION: There was no correlation between maternal and cord leptin, which supports the hypothesis of a noncommunicating, two-compartment model of fetoplacental leptin regulation. SN - 1071-5576 UR - https://www.unboundmedicine.com/medline/citation/11223357/Maternal_serum_leptin_concentrations_do_not_correlate_with_cord_blood_leptin_concentrations_in_normal_pregnancy_ L2 - http://www.diseaseinfosearch.org/result/5922 DB - PRIME DP - Unbound Medicine ER -