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Effects of naltrexone pretreatment on the subjective and performance effects of ethanol in social drinkers.
Behav Pharmacol. 1995 Jun; 6(4):386-394.BP

Abstract

Clinical trials suggest that opioid antagonists may be effective in the treatment of alcoholism. For example, two recent clinical trials reported that alcoholics treated with the opioid antagonist naltrexone exhibited higher abstinence rates, decreased craving and a decrease in the amount of alcohol consumed if drinking occurred. The present study examined the hypothesis that naltrexone pretreatment would attenuate the behavioral responses to an acute dose of ethanol in normal, healthy social drinkers. Thirteen healthy male and female social drinkers participated in a six-session, double-blind, placebo-controlled, crossover design study. On each session, subjects ingested a capsule containing naltrexone (25 or 50mg) or placebo and one hour later consumed a beverage containing ethanol (0.5g/kg) or placebo. For three hours after the beverage was consumed, breath alcohol levels were measured and subjects completed standardized subjective effects questionnaires and performance tasks at regular intervals. Ethanol alone produced its prototypic effects, including positive subjective responses such as euphoria and increased ratings of overall liking, as well as increased ratings of confusion. Ethanol also impaired performance on a verbal recall task. Naltrexone alone produced few subjective effects and did not impair psychomotor or verbal recall performance. Contrary to our hypothesis, pretreatment with naltrexone did not alter the positive subjective effects, or any other effects, of ethanol. Further research is needed to determine the influence of factors such as baseline level of ethanol consumption or duration of naltrexone treatment on the interaction between ethanol and the endogenous opioid system.

Authors+Show Affiliations

Department of Psychiatry, MC3077, University of Chicago, Chicago, IL 60637, USA.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11224347

Citation

Doty, P., and H. de Wit. "Effects of Naltrexone Pretreatment On the Subjective and Performance Effects of Ethanol in Social Drinkers." Behavioural Pharmacology, vol. 6, no. 4, 1995, pp. 386-394.
Doty P, de Wit H. Effects of naltrexone pretreatment on the subjective and performance effects of ethanol in social drinkers. Behav Pharmacol. 1995;6(4):386-394.
Doty, P., & de Wit, H. (1995). Effects of naltrexone pretreatment on the subjective and performance effects of ethanol in social drinkers. Behavioural Pharmacology, 6(4), 386-394.
Doty P, de Wit H. Effects of Naltrexone Pretreatment On the Subjective and Performance Effects of Ethanol in Social Drinkers. Behav Pharmacol. 1995;6(4):386-394. PubMed PMID: 11224347.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of naltrexone pretreatment on the subjective and performance effects of ethanol in social drinkers. AU - Doty,P., AU - de Wit,H., PY - 1995/6/1/pubmed PY - 2001/2/27/medline PY - 1995/6/1/entrez SP - 386 EP - 394 JF - Behavioural pharmacology JO - Behav Pharmacol VL - 6 IS - 4 N2 - Clinical trials suggest that opioid antagonists may be effective in the treatment of alcoholism. For example, two recent clinical trials reported that alcoholics treated with the opioid antagonist naltrexone exhibited higher abstinence rates, decreased craving and a decrease in the amount of alcohol consumed if drinking occurred. The present study examined the hypothesis that naltrexone pretreatment would attenuate the behavioral responses to an acute dose of ethanol in normal, healthy social drinkers. Thirteen healthy male and female social drinkers participated in a six-session, double-blind, placebo-controlled, crossover design study. On each session, subjects ingested a capsule containing naltrexone (25 or 50mg) or placebo and one hour later consumed a beverage containing ethanol (0.5g/kg) or placebo. For three hours after the beverage was consumed, breath alcohol levels were measured and subjects completed standardized subjective effects questionnaires and performance tasks at regular intervals. Ethanol alone produced its prototypic effects, including positive subjective responses such as euphoria and increased ratings of overall liking, as well as increased ratings of confusion. Ethanol also impaired performance on a verbal recall task. Naltrexone alone produced few subjective effects and did not impair psychomotor or verbal recall performance. Contrary to our hypothesis, pretreatment with naltrexone did not alter the positive subjective effects, or any other effects, of ethanol. Further research is needed to determine the influence of factors such as baseline level of ethanol consumption or duration of naltrexone treatment on the interaction between ethanol and the endogenous opioid system. SN - 1473-5849 UR - https://www.unboundmedicine.com/medline/citation/11224347/Effects_of_naltrexone_pretreatment_on_the_subjective_and_performance_effects_of_ethanol_in_social_drinkers_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=11224347.ui DB - PRIME DP - Unbound Medicine ER -
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