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Genetic epidemiology of primary osteoarthritis.
Curr Opin Rheumatol. 2001 Mar; 13(2):111-6.CO

Abstract

Primary osteoarthritis (OA) is a late onset disease that fits most accurately into the oligogenic, multifactorial class of genetic diseases. Twin pair and family risk studies have highlighted a surprisingly large genetic component to OA and have prompted the search for predisposing genes. These searches have taken three forms: (1) parametric linkage analysis of rare families in which OA segregates as a Mendelian trait, (2) model-free linkage analysis of affected sibling pairs, and (3) association analysis of known candidate genes. Within the past year linkage analysis studies have highlighted that chromosomes 2, 4, 6, 7, 11, 16, and the X may each harbor an OA susceptibility gene. Chromosomes 2, 4, and 16 were identified in multiple genome scans and are therefore the most likely to encode susceptibility. Association analysis of candidates suggests that the syntenic genes for type II collagen and the vitamin D receptor (12q12--q13.1) may also encode for OA susceptibility.

Authors+Show Affiliations

Loughlin J
University of Oxford, Institute of Molecular Medicine, Oxford, UK. john.loughlin@ndcls.ox.ac.uk

MeSH

Diseases in TwinsFemaleGenesGenetic LinkageHumansMaleNuclear FamilyOsteoarthritisRisk FactorsTwin Studies as Topic

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

11224735

Citation

Loughlin, J. "Genetic Epidemiology of Primary Osteoarthritis." Current Opinion in Rheumatology, vol. 13, no. 2, 2001, pp. 111-6.
Loughlin J. Genetic epidemiology of primary osteoarthritis. Curr Opin Rheumatol. 2001;13(2):111-6.
Loughlin, J. (2001). Genetic epidemiology of primary osteoarthritis. Current Opinion in Rheumatology, 13(2), 111-6.
Loughlin J. Genetic Epidemiology of Primary Osteoarthritis. Curr Opin Rheumatol. 2001;13(2):111-6. PubMed PMID: 11224735.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic epidemiology of primary osteoarthritis. A1 - Loughlin,J, PY - 2001/2/27/pubmed PY - 2001/6/2/medline PY - 2001/2/27/entrez SP - 111 EP - 6 JF - Current opinion in rheumatology JO - Curr Opin Rheumatol VL - 13 IS - 2 N2 - Primary osteoarthritis (OA) is a late onset disease that fits most accurately into the oligogenic, multifactorial class of genetic diseases. Twin pair and family risk studies have highlighted a surprisingly large genetic component to OA and have prompted the search for predisposing genes. These searches have taken three forms: (1) parametric linkage analysis of rare families in which OA segregates as a Mendelian trait, (2) model-free linkage analysis of affected sibling pairs, and (3) association analysis of known candidate genes. Within the past year linkage analysis studies have highlighted that chromosomes 2, 4, 6, 7, 11, 16, and the X may each harbor an OA susceptibility gene. Chromosomes 2, 4, and 16 were identified in multiple genome scans and are therefore the most likely to encode susceptibility. Association analysis of candidates suggests that the syntenic genes for type II collagen and the vitamin D receptor (12q12--q13.1) may also encode for OA susceptibility. SN - 1040-8711 UR - https://www.unboundmedicine.com/medline/citation/11224735/Genetic_epidemiology_of_primary_osteoarthritis_ DB - PRIME DP - Unbound Medicine ER -