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Olfaction and its alteration by nasal obstruction, rhinitis, and rhinosinusitis.

Abstract

The sense of smell has been largely ignored by otorhinolaryngologists, even though 1) its medical stewardship falls within their specialty's purview, 2) olfactory dysfunction is not uncommon in the general population, and 3) disorders of olfaction have significant quality of life, nutritional, and safety consequences. This report provides a succinct overview of the major intranasal neural systems present in humans (namely, cranial nerves O, I, and V, and the nonfunctional accessory [vomeronasal] organ system), along with a summary of notable findings resulting from the application of modern olfactory tests to patient populations, emphasizing diseases of the nose. Such tests have led to the discovery of significant influences of age, gender, smoking, toxic exposure, and genetics on the ability to smell. Within the field of otorhinolaryngology, they have revealed that 1) surgical and medical interventions in patients with rhinosinusitis do not, on average, lead to complete recovery of olfactory function, despite common beliefs to the contrary, and 2) associations are generally lacking between measures of airway patency and olfactory function in such cases. These findings have thrown into question the dogma that olfactory loss in rhinosinusitis is attributable primarily to blockage of airflow to the receptors and have led to histopathological studies demonstrating significant olfactory epithelial compromise in sinonasal syndromes.

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  • Authors+Show Affiliations

    ,

    Smell and Taste Center, Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania Medical Center, 5 Ravdin Building, 3400 Spruce St., Philadelphia, PA 19104, USA.

    Source

    The Laryngoscope 111:3 2001 Mar pg 409-23

    MeSH

    Cranial Nerves
    Humans
    Nasal Obstruction
    Olfaction Disorders
    Rhinitis
    Sinusitis

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.
    Review

    Language

    eng

    PubMed ID

    11224769

    Citation

    Doty, R L., and A Mishra. "Olfaction and Its Alteration By Nasal Obstruction, Rhinitis, and Rhinosinusitis." The Laryngoscope, vol. 111, no. 3, 2001, pp. 409-23.
    Doty RL, Mishra A. Olfaction and its alteration by nasal obstruction, rhinitis, and rhinosinusitis. Laryngoscope. 2001;111(3):409-23.
    Doty, R. L., & Mishra, A. (2001). Olfaction and its alteration by nasal obstruction, rhinitis, and rhinosinusitis. The Laryngoscope, 111(3), pp. 409-23.
    Doty RL, Mishra A. Olfaction and Its Alteration By Nasal Obstruction, Rhinitis, and Rhinosinusitis. Laryngoscope. 2001;111(3):409-23. PubMed PMID: 11224769.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Olfaction and its alteration by nasal obstruction, rhinitis, and rhinosinusitis. AU - Doty,R L, AU - Mishra,A, PY - 2001/2/27/pubmed PY - 2001/4/3/medline PY - 2001/2/27/entrez SP - 409 EP - 23 JF - The Laryngoscope JO - Laryngoscope VL - 111 IS - 3 N2 - The sense of smell has been largely ignored by otorhinolaryngologists, even though 1) its medical stewardship falls within their specialty's purview, 2) olfactory dysfunction is not uncommon in the general population, and 3) disorders of olfaction have significant quality of life, nutritional, and safety consequences. This report provides a succinct overview of the major intranasal neural systems present in humans (namely, cranial nerves O, I, and V, and the nonfunctional accessory [vomeronasal] organ system), along with a summary of notable findings resulting from the application of modern olfactory tests to patient populations, emphasizing diseases of the nose. Such tests have led to the discovery of significant influences of age, gender, smoking, toxic exposure, and genetics on the ability to smell. Within the field of otorhinolaryngology, they have revealed that 1) surgical and medical interventions in patients with rhinosinusitis do not, on average, lead to complete recovery of olfactory function, despite common beliefs to the contrary, and 2) associations are generally lacking between measures of airway patency and olfactory function in such cases. These findings have thrown into question the dogma that olfactory loss in rhinosinusitis is attributable primarily to blockage of airflow to the receptors and have led to histopathological studies demonstrating significant olfactory epithelial compromise in sinonasal syndromes. SN - 0023-852X UR - https://www.unboundmedicine.com/medline/citation/11224769/Olfaction_and_its_alteration_by_nasal_obstruction_rhinitis_and_rhinosinusitis_ L2 - https://doi.org/10.1097/00005537-200103000-00008 DB - PRIME DP - Unbound Medicine ER -