[Antiinfluenza-drugs and the standard of the use].Nihon Rinsho. 2000 Nov; 58(11):2283-7.NR
Amantadine is only effective for influenza A, but zanamivir and oseltamivir, neuramidase inhibitors are strongly effective for influenza A and B. At this time we are available for amantadine and zanamivir for influenza in Japan. Oseltamivir is now under investigation in Japan. In USA both new drugs have been approved by USA government. Influenza vaccine is the first line drug for prevention of influenza A and B. In cases influenza infection occurs, we should promptly select and give antiinfluenza drug for these patients during almost 5 days, considering renal condition. And we should keep in mind that these antiviral substances are not directly effective for inflammatory phenomenons which introduce the reduction of lung function. So we should use both therapies which include antiviral chemotherapy and serious rescue treatment for respiratory failure.