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Hormonal and clinical effects of GnRH agonist alone, or in combination with a combined oral contraceptive or flutamide in women with severe hirsutism.
Gynecol Endocrinol. 2000 Dec; 14(6):411-6.GE

Abstract

The objective of this prospective randomized study was to evaluate and compare the hormonal and clinical effects of long-acting gonadotropin-releasing hormone (GnRH) agonist and a combination of GnRH agonist with combined oral contraceptive (COC) or flutamide in women with polycystic ovary syndrome (PCOS). Thirty-five hirsute women with PCOS, ranging in age from 19-27 years, were randomly divided into three groups: group A treated with GnRH agonist (n = 12), group B (n = 12) treated with GnRH agonist plus COC and group C (n = 11) treated with GnRH agonist plus flutamide for 6 months. Before, at the end and 6 months after the end of treatment, blood samples were drawn from all women (in early follicular phase in those with menstrual cycles) to measure ovarian and adrenal androgens, gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH), estradiol and estrone plasma levels. The results showed that all three protocols had good therapeutic efficacy. A significant reduction in hirsutism was observed in all patients after 6 months of therapy, the Ferriman-Gallwey scores dropping to 9 +/- 3 in group A, 10 +/- 4 in group B and 11 +/- 5 in group C. Six months after the end of therapy, the hirsutism score continued to be significantly reduced in all groups. After 6 months of therapy, a reduction in plasma levels of LH, FSH, estrone, estradiol, testosterone, free testosterone, androstenedione and dehydroepiandrosterone sulfate (DHEAS) was observed in all groups although this was more pronounced in group B and group C. These therapies may be the basis of future treatments that quickly reduce hirsutism and remove its causes by reducing the secretion of ovarian and adrenal androgens and by blocking androgen receptors.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, University of Siena, Policlinico Le Scotte, Viale Bracci, 53100 Siena, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

11228061

Citation

De Leo, V, et al. "Hormonal and Clinical Effects of GnRH Agonist Alone, or in Combination With a Combined Oral Contraceptive or Flutamide in Women With Severe Hirsutism." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 14, no. 6, 2000, pp. 411-6.
De Leo V, Fulghesu AM, la Marca A, et al. Hormonal and clinical effects of GnRH agonist alone, or in combination with a combined oral contraceptive or flutamide in women with severe hirsutism. Gynecol Endocrinol. 2000;14(6):411-6.
De Leo, V., Fulghesu, A. M., la Marca, A., Morgante, G., Pasqui, L., Talluri, B., Torricelli, M., & Caruso, A. (2000). Hormonal and clinical effects of GnRH agonist alone, or in combination with a combined oral contraceptive or flutamide in women with severe hirsutism. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 14(6), 411-6.
De Leo V, et al. Hormonal and Clinical Effects of GnRH Agonist Alone, or in Combination With a Combined Oral Contraceptive or Flutamide in Women With Severe Hirsutism. Gynecol Endocrinol. 2000;14(6):411-6. PubMed PMID: 11228061.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hormonal and clinical effects of GnRH agonist alone, or in combination with a combined oral contraceptive or flutamide in women with severe hirsutism. AU - De Leo,V, AU - Fulghesu,A M, AU - la Marca,A, AU - Morgante,G, AU - Pasqui,L, AU - Talluri,B, AU - Torricelli,M, AU - Caruso,A, PY - 2001/3/3/pubmed PY - 2001/5/22/medline PY - 2001/3/3/entrez SP - 411 EP - 6 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol Endocrinol VL - 14 IS - 6 N2 - The objective of this prospective randomized study was to evaluate and compare the hormonal and clinical effects of long-acting gonadotropin-releasing hormone (GnRH) agonist and a combination of GnRH agonist with combined oral contraceptive (COC) or flutamide in women with polycystic ovary syndrome (PCOS). Thirty-five hirsute women with PCOS, ranging in age from 19-27 years, were randomly divided into three groups: group A treated with GnRH agonist (n = 12), group B (n = 12) treated with GnRH agonist plus COC and group C (n = 11) treated with GnRH agonist plus flutamide for 6 months. Before, at the end and 6 months after the end of treatment, blood samples were drawn from all women (in early follicular phase in those with menstrual cycles) to measure ovarian and adrenal androgens, gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH), estradiol and estrone plasma levels. The results showed that all three protocols had good therapeutic efficacy. A significant reduction in hirsutism was observed in all patients after 6 months of therapy, the Ferriman-Gallwey scores dropping to 9 +/- 3 in group A, 10 +/- 4 in group B and 11 +/- 5 in group C. Six months after the end of therapy, the hirsutism score continued to be significantly reduced in all groups. After 6 months of therapy, a reduction in plasma levels of LH, FSH, estrone, estradiol, testosterone, free testosterone, androstenedione and dehydroepiandrosterone sulfate (DHEAS) was observed in all groups although this was more pronounced in group B and group C. These therapies may be the basis of future treatments that quickly reduce hirsutism and remove its causes by reducing the secretion of ovarian and adrenal androgens and by blocking androgen receptors. SN - 0951-3590 UR - https://www.unboundmedicine.com/medline/citation/11228061/Hormonal_and_clinical_effects_of_GnRH_agonist_alone_or_in_combination_with_a_combined_oral_contraceptive_or_flutamide_in_women_with_severe_hirsutism_ DB - PRIME DP - Unbound Medicine ER -