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Green tea and the risk of gastric cancer in Japan.
N Engl J Med. 2001 Mar 01; 344(9):632-6.NEJM

Abstract

BACKGROUND

Although laboratory experiments and case-control studies have suggested that the consumption of green tea provides protection against gastric cancer, few prospective studies have been performed.

METHODS

In January 1984, a total of 26,311 residents in three municipalities of Miyagi Prefecture, in northern Japan (11,902 men and 14,409 women 40 years of age or older), completed a self-administered questionnaire that included questions about the frequency of consumption of green tea. During 199,748 person-years of follow-up, through December 1992, we identified 419 cases of gastric cancer (in 296 men and 123 women). We used Cox regression to estimate the relative risk of gastric cancer according to the consumption of green tea.

RESULTS

Green-tea consumption was not associated with the risk of gastric cancer. After adjustment for sex, age, presence or absence of a history of peptic ulcer smoking status, alcohol consumption, other dietary elements, and type of health insurance, the relative risks associated with drinking one or two, three or four, and five or more cups of green tea per day, as compared with less than one cup per day, were 1.1 (95 percent confidence interval, 0.8 to 1.6), 1.0 (95 percent confidence interval, 0.7 to 1.4), and 1.2 (95 percent confidence interval, 0.9 to 1.6), respectively (P for trend=0.13). The results were similar after the 117 cases of gastric cancer that were diagnosed in the first three years of follow-up had been excluded, with respective relative risks of 1.2 (95 percent confidence interval, 0.8 to 1.8) 1.0 (95 percent confidence interval, 0.7 to 1.5), and 1.4 (95 percent confidence interval, 1.0 to 1.9) (P for trend=0.07).

CONCLUSIONS

In a population-based, prospective cohort study in Japan, we found no association between green-tea consumption and the risk of gastric cancer.

Authors+Show Affiliations

Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan. ytsubono@metamedica.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11228277

Citation

Tsubono, Y, et al. "Green Tea and the Risk of Gastric Cancer in Japan." The New England Journal of Medicine, vol. 344, no. 9, 2001, pp. 632-6.
Tsubono Y, Nishino Y, Komatsu S, et al. Green tea and the risk of gastric cancer in Japan. N Engl J Med. 2001;344(9):632-6.
Tsubono, Y., Nishino, Y., Komatsu, S., Hsieh, C. C., Kanemura, S., Tsuji, I., Nakatsuka, H., Fukao, A., Satoh, H., & Hisamichi, S. (2001). Green tea and the risk of gastric cancer in Japan. The New England Journal of Medicine, 344(9), 632-6.
Tsubono Y, et al. Green Tea and the Risk of Gastric Cancer in Japan. N Engl J Med. 2001 Mar 1;344(9):632-6. PubMed PMID: 11228277.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Green tea and the risk of gastric cancer in Japan. AU - Tsubono,Y, AU - Nishino,Y, AU - Komatsu,S, AU - Hsieh,C C, AU - Kanemura,S, AU - Tsuji,I, AU - Nakatsuka,H, AU - Fukao,A, AU - Satoh,H, AU - Hisamichi,S, PY - 2001/3/3/pubmed PY - 2001/3/17/medline PY - 2001/3/3/entrez SP - 632 EP - 6 JF - The New England journal of medicine JO - N Engl J Med VL - 344 IS - 9 N2 - BACKGROUND: Although laboratory experiments and case-control studies have suggested that the consumption of green tea provides protection against gastric cancer, few prospective studies have been performed. METHODS: In January 1984, a total of 26,311 residents in three municipalities of Miyagi Prefecture, in northern Japan (11,902 men and 14,409 women 40 years of age or older), completed a self-administered questionnaire that included questions about the frequency of consumption of green tea. During 199,748 person-years of follow-up, through December 1992, we identified 419 cases of gastric cancer (in 296 men and 123 women). We used Cox regression to estimate the relative risk of gastric cancer according to the consumption of green tea. RESULTS: Green-tea consumption was not associated with the risk of gastric cancer. After adjustment for sex, age, presence or absence of a history of peptic ulcer smoking status, alcohol consumption, other dietary elements, and type of health insurance, the relative risks associated with drinking one or two, three or four, and five or more cups of green tea per day, as compared with less than one cup per day, were 1.1 (95 percent confidence interval, 0.8 to 1.6), 1.0 (95 percent confidence interval, 0.7 to 1.4), and 1.2 (95 percent confidence interval, 0.9 to 1.6), respectively (P for trend=0.13). The results were similar after the 117 cases of gastric cancer that were diagnosed in the first three years of follow-up had been excluded, with respective relative risks of 1.2 (95 percent confidence interval, 0.8 to 1.8) 1.0 (95 percent confidence interval, 0.7 to 1.5), and 1.4 (95 percent confidence interval, 1.0 to 1.9) (P for trend=0.07). CONCLUSIONS: In a population-based, prospective cohort study in Japan, we found no association between green-tea consumption and the risk of gastric cancer. SN - 0028-4793 UR - https://www.unboundmedicine.com/medline/citation/11228277/Green_tea_and_the_risk_of_gastric_cancer_in_Japan_ L2 - https://www.nejm.org/doi/10.1056/NEJM200103013440903?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -