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An Australian twin study of the genetic basis of preeclampsia and eclampsia.
Am J Obstet Gynecol 2001; 184(3):374-81AJ

Abstract

OBJECTIVE

We investigated maternal versus fetal genetic causes of preeclampsia and eclampsia by assessing concordance between monozygotic and dizygotic female co-twins, between female partners of male monozygotic and dizygotic twin pairs, and between female twins and partners of their male co-twins in dizygotic opposite-sex pairs.

STUDY DESIGN

Two large birth cohorts of volunteer Australian female twin pairs (N = 1504 pairs and N = 858 pairs) were screened and interviewed, and available medical and hospital records were obtained and reviewed where indicated, with diagnoses assigned according to predetermined criteria.

RESULTS

With strict diagnostic criteria used for preeclampsia and eclampsia, no concordant female twin pairs were found. Collapsing diagnoses of definite, probable, or possible preeclampsia or eclampsia resulted in very low genetic recurrence risk estimates.

CONCLUSION

Results from these two cohorts of female twin pairs do not support clear, solely maternal genetic influences on preeclampsia and eclampsia. Numbers of parous female partners of male twins were too low for conclusions to be drawn regarding paternal transmission.

Authors+Show Affiliations

Queensland Institute of Medical Research and the Joint Genetics Program, The University of Queensland, Brisbane, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Twin Study

Language

eng

PubMed ID

11228490

Citation

Treloar, S A., et al. "An Australian Twin Study of the Genetic Basis of Preeclampsia and Eclampsia." American Journal of Obstetrics and Gynecology, vol. 184, no. 3, 2001, pp. 374-81.
Treloar SA, Cooper DW, Brennecke SP, et al. An Australian twin study of the genetic basis of preeclampsia and eclampsia. Am J Obstet Gynecol. 2001;184(3):374-81.
Treloar, S. A., Cooper, D. W., Brennecke, S. P., Grehan, M. M., & Martin, N. G. (2001). An Australian twin study of the genetic basis of preeclampsia and eclampsia. American Journal of Obstetrics and Gynecology, 184(3), pp. 374-81.
Treloar SA, et al. An Australian Twin Study of the Genetic Basis of Preeclampsia and Eclampsia. Am J Obstet Gynecol. 2001;184(3):374-81. PubMed PMID: 11228490.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An Australian twin study of the genetic basis of preeclampsia and eclampsia. AU - Treloar,S A, AU - Cooper,D W, AU - Brennecke,S P, AU - Grehan,M M, AU - Martin,N G, PY - 2001/3/3/pubmed PY - 2001/4/3/medline PY - 2001/3/3/entrez SP - 374 EP - 81 JF - American journal of obstetrics and gynecology JO - Am. J. Obstet. Gynecol. VL - 184 IS - 3 N2 - OBJECTIVE: We investigated maternal versus fetal genetic causes of preeclampsia and eclampsia by assessing concordance between monozygotic and dizygotic female co-twins, between female partners of male monozygotic and dizygotic twin pairs, and between female twins and partners of their male co-twins in dizygotic opposite-sex pairs. STUDY DESIGN: Two large birth cohorts of volunteer Australian female twin pairs (N = 1504 pairs and N = 858 pairs) were screened and interviewed, and available medical and hospital records were obtained and reviewed where indicated, with diagnoses assigned according to predetermined criteria. RESULTS: With strict diagnostic criteria used for preeclampsia and eclampsia, no concordant female twin pairs were found. Collapsing diagnoses of definite, probable, or possible preeclampsia or eclampsia resulted in very low genetic recurrence risk estimates. CONCLUSION: Results from these two cohorts of female twin pairs do not support clear, solely maternal genetic influences on preeclampsia and eclampsia. Numbers of parous female partners of male twins were too low for conclusions to be drawn regarding paternal transmission. SN - 0002-9378 UR - https://www.unboundmedicine.com/medline/citation/11228490/An_Australian_twin_study_of_the_genetic_basis_of_preeclampsia_and_eclampsia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9378(01)65953-2 DB - PRIME DP - Unbound Medicine ER -