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Brainstem auditory evoked potentials and somatosensory evoked potentials in cerebral malaria--a prognostic significance.
J Assoc Physicians India. 2000 Mar; 48(3):295-300.JA

Abstract

OBJECTIVE

To study the changes in brainstem auditory evoked potentials (BAEPs) and somatosensory evoked potentials (SSEPs) in cerebral malaria and to see their prognostic significance.

METHODS

BAEPs and right median nerve SSEPs were performed in 25 adult patients of strictly defined cerebral malaria in acute stage in a semi-dark, sound proof chamber on four channel computerized multi-basis OTE-Biomedica machine in department of neurology, SP Medical College, Bikaner.

RESULTS

The abnormalities of BAEPs were delayed peak latency of wave III in 13/25 (52%) and wave V in 20/25 (80%) patients and delayed interpeak latencies (IPLs) of wave I-III in 9/25 (36%), wave I-V in 15/25 (60%) and wave III-V in 12/25 (48%) patients. In SSEPs delayed N20 was seen in 11/25 (44%); delayed IPLs of N13-N20 (central conduction time; CCT) in 12/25 (48%) patients. Distorted N20 was recorded in 12/25 (48%) patients. Both N13-N20 IPLs in SSEPs and wave III-V IPLs in BAEPs were delayed in five patients and all of them expired. Delayed N13-N20 with normal III-V IPLs was present in seven patients and two of them died, whereas delayed III-V IPLs with normal N13-N20 was present in seven patients, and one of them expired. In remaining six patients both the parameters were normal and one of them died.

CONCLUSIONS

The values of BAEPs and SSEPs were abnormal in patients of cerebral malaria and it was observed that BAEPs/SSEPs alone was not useful for predicting the outcome of coma, whereas abnormalities in both was predictive of worst prognosis. The changes in evoked potentials (BAEPs and SSEPs) could be due to either interruption of conduction in central pathways because of structural changes due to petechial hemorrhages and malarial granuloma at multiple levels in the brain including brainstem or due to metabolic abnormalities.

Authors+Show Affiliations

Department of Medicine, Neurology Section, Cerebral Malaria Clinic, SP Medical College, Bikaner-334 003.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11229113

Citation

Kochar, D K., et al. "Brainstem Auditory Evoked Potentials and Somatosensory Evoked Potentials in Cerebral Malaria--a Prognostic Significance." The Journal of the Association of Physicians of India, vol. 48, no. 3, 2000, pp. 295-300.
Kochar DK, Kumawat BL, Halwai M, et al. Brainstem auditory evoked potentials and somatosensory evoked potentials in cerebral malaria--a prognostic significance. J Assoc Physicians India. 2000;48(3):295-300.
Kochar, D. K., Kumawat, B. L., Halwai, M., Kochar, S. K., Shubhakaran, ., & Thanvi, I. (2000). Brainstem auditory evoked potentials and somatosensory evoked potentials in cerebral malaria--a prognostic significance. The Journal of the Association of Physicians of India, 48(3), 295-300.
Kochar DK, et al. Brainstem Auditory Evoked Potentials and Somatosensory Evoked Potentials in Cerebral Malaria--a Prognostic Significance. J Assoc Physicians India. 2000;48(3):295-300. PubMed PMID: 11229113.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Brainstem auditory evoked potentials and somatosensory evoked potentials in cerebral malaria--a prognostic significance. AU - Kochar,D K, AU - Kumawat,B L, AU - Halwai,M, AU - Kochar,S K, AU - Shubhakaran,, AU - Thanvi,I, PY - 2001/3/7/pubmed PY - 2001/3/17/medline PY - 2001/3/7/entrez SP - 295 EP - 300 JF - The Journal of the Association of Physicians of India JO - J Assoc Physicians India VL - 48 IS - 3 N2 - OBJECTIVE: To study the changes in brainstem auditory evoked potentials (BAEPs) and somatosensory evoked potentials (SSEPs) in cerebral malaria and to see their prognostic significance. METHODS: BAEPs and right median nerve SSEPs were performed in 25 adult patients of strictly defined cerebral malaria in acute stage in a semi-dark, sound proof chamber on four channel computerized multi-basis OTE-Biomedica machine in department of neurology, SP Medical College, Bikaner. RESULTS: The abnormalities of BAEPs were delayed peak latency of wave III in 13/25 (52%) and wave V in 20/25 (80%) patients and delayed interpeak latencies (IPLs) of wave I-III in 9/25 (36%), wave I-V in 15/25 (60%) and wave III-V in 12/25 (48%) patients. In SSEPs delayed N20 was seen in 11/25 (44%); delayed IPLs of N13-N20 (central conduction time; CCT) in 12/25 (48%) patients. Distorted N20 was recorded in 12/25 (48%) patients. Both N13-N20 IPLs in SSEPs and wave III-V IPLs in BAEPs were delayed in five patients and all of them expired. Delayed N13-N20 with normal III-V IPLs was present in seven patients and two of them died, whereas delayed III-V IPLs with normal N13-N20 was present in seven patients, and one of them expired. In remaining six patients both the parameters were normal and one of them died. CONCLUSIONS: The values of BAEPs and SSEPs were abnormal in patients of cerebral malaria and it was observed that BAEPs/SSEPs alone was not useful for predicting the outcome of coma, whereas abnormalities in both was predictive of worst prognosis. The changes in evoked potentials (BAEPs and SSEPs) could be due to either interruption of conduction in central pathways because of structural changes due to petechial hemorrhages and malarial granuloma at multiple levels in the brain including brainstem or due to metabolic abnormalities. SN - 0004-5772 UR - https://www.unboundmedicine.com/medline/citation/11229113/Brainstem_auditory_evoked_potentials_and_somatosensory_evoked_potentials_in_cerebral_malaria__a_prognostic_significance_ L2 - http://www.diseaseinfosearch.org/result/4415 DB - PRIME DP - Unbound Medicine ER -