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Widespread pain among 11-year-old Finnish twin pairs.
Arthritis Rheum 2001; 44(2):481-5AR

Abstract

OBJECTIVE

To examine the prevalence of widespread musculoskeletal pain (WSP) symptoms in 11-year-old Finnish twins and to determine the relative role of genetic and environmental factors in the etiology of WSP.

METHODS

Data on current pain items were collected from 1995 to 1998 from a national sample of Finnish families with 11-year-old twins born between 1984 and 1987. The presence of WSP was determined using a validated questionnaire method. Pairwise similarity was computed for 583 monozygotic (MZ) pairs, 588 same-sex dizygotic (DZ) pairs, and 618 opposite-sex DZ twin pairs. Variance components for genetic and environmental factors were estimated using biometric structural equation modeling techniques.

RESULTS

The prevalence of WSP was 9.9%, with no sex difference. The majority of twin pairs with WSP were discordant. The tetrachoric correlations for male MZ (r = 0.38), male DZ (r = 0.37), female MZ (r = 0.59), female DZ (r = 0.54), and opposite-sex pairs (r = 0.43) showed little difference by zygosity. Female pairs were more concordant than male pairs among both MZ and DZ twins. Biometric model-fitting indicated that genetic factors did not account for the pattern of twin similarity. Among boys 35%, and among girls 56%, of the variation in liability to WSP could be attributed to shared familial environmental effects. The remainder was attributed to unshared environmental effects.

CONCLUSION

Genetic factors seem to play at most a minor role in WSP in 11-year-old twins, and environmental factors shared by family members account for a substantial proportion of the variability in WSP.

Authors+Show Affiliations

The Rheumatism Foundation Hospital, Heinola, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Twin Study

Language

eng

PubMed ID

11229481

Citation

Mikkelsson, M, et al. "Widespread Pain Among 11-year-old Finnish Twin Pairs." Arthritis and Rheumatism, vol. 44, no. 2, 2001, pp. 481-5.
Mikkelsson M, Kaprio J, Salminen JJ, et al. Widespread pain among 11-year-old Finnish twin pairs. Arthritis Rheum. 2001;44(2):481-5.
Mikkelsson, M., Kaprio, J., Salminen, J. J., Pulkkinen, L., & Rose, R. J. (2001). Widespread pain among 11-year-old Finnish twin pairs. Arthritis and Rheumatism, 44(2), pp. 481-5.
Mikkelsson M, et al. Widespread Pain Among 11-year-old Finnish Twin Pairs. Arthritis Rheum. 2001;44(2):481-5. PubMed PMID: 11229481.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Widespread pain among 11-year-old Finnish twin pairs. AU - Mikkelsson,M, AU - Kaprio,J, AU - Salminen,J J, AU - Pulkkinen,L, AU - Rose,R J, PY - 2001/3/7/pubmed PY - 2001/3/27/medline PY - 2001/3/7/entrez SP - 481 EP - 5 JF - Arthritis and rheumatism JO - Arthritis Rheum. VL - 44 IS - 2 N2 - OBJECTIVE: To examine the prevalence of widespread musculoskeletal pain (WSP) symptoms in 11-year-old Finnish twins and to determine the relative role of genetic and environmental factors in the etiology of WSP. METHODS: Data on current pain items were collected from 1995 to 1998 from a national sample of Finnish families with 11-year-old twins born between 1984 and 1987. The presence of WSP was determined using a validated questionnaire method. Pairwise similarity was computed for 583 monozygotic (MZ) pairs, 588 same-sex dizygotic (DZ) pairs, and 618 opposite-sex DZ twin pairs. Variance components for genetic and environmental factors were estimated using biometric structural equation modeling techniques. RESULTS: The prevalence of WSP was 9.9%, with no sex difference. The majority of twin pairs with WSP were discordant. The tetrachoric correlations for male MZ (r = 0.38), male DZ (r = 0.37), female MZ (r = 0.59), female DZ (r = 0.54), and opposite-sex pairs (r = 0.43) showed little difference by zygosity. Female pairs were more concordant than male pairs among both MZ and DZ twins. Biometric model-fitting indicated that genetic factors did not account for the pattern of twin similarity. Among boys 35%, and among girls 56%, of the variation in liability to WSP could be attributed to shared familial environmental effects. The remainder was attributed to unshared environmental effects. CONCLUSION: Genetic factors seem to play at most a minor role in WSP in 11-year-old twins, and environmental factors shared by family members account for a substantial proportion of the variability in WSP. SN - 0004-3591 UR - https://www.unboundmedicine.com/medline/citation/11229481/Widespread_pain_among_11_year_old_Finnish_twin_pairs_ L2 - https://doi.org/10.1002/1529-0131(200102)44:2<481::AID-ANR68>3.0.CO;2-X DB - PRIME DP - Unbound Medicine ER -