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Risk factors for severe pulmonary and disseminated coccidioidomycosis: Kern County, California, 1995-1996.
Clin Infect Dis. 2001 Mar 01; 32(5):708-15.CI

Abstract

Surveillance for coccidioidomycosis (CM) and a case-control study for risk factors among adults were conducted in Kern County, California. From January 1995 through December 1996, 905 cases of CM were identified, for an annual incidence of 86 cases per 100,000 population. A total of 380 adults were enrolled in the case-control study: 77 had severe pulmonary disease, 33 had disseminated disease, and 270 control patients had mild disease. Independent risk factors for severe pulmonary disease included diabetes, recent history of cigarette smoking, income of < $15,000 per year, and older age. Oral antifungal therapy before hospitalization was associated with a reduced risk of CM pneumonia. Risk factors for disseminated disease were black race, income of < $15,000 per year, and pregnancy. Early treatment of CM with oral antifungal agents may prevent severe pulmonary disease in groups considered to be at high risk, such as elderly individuals, persons with diabetes, and smokers. Persons at risk for severe CM may benefit from vaccination once an effective CM vaccine is available.

Authors+Show Affiliations

Meningitis and Special Pathogens Branch, Division of Bacterial and Mycotic Diseases, NCID, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. nar5@cdc.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11229838

Citation

Rosenstein, N E., et al. "Risk Factors for Severe Pulmonary and Disseminated Coccidioidomycosis: Kern County, California, 1995-1996." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 32, no. 5, 2001, pp. 708-15.
Rosenstein NE, Emery KW, Werner SB, et al. Risk factors for severe pulmonary and disseminated coccidioidomycosis: Kern County, California, 1995-1996. Clin Infect Dis. 2001;32(5):708-15.
Rosenstein, N. E., Emery, K. W., Werner, S. B., Kao, A., Johnson, R., Rogers, D., Vugia, D., Reingold, A., Talbot, R., Plikaytis, B. D., Perkins, B. A., & Hajjeh, R. A. (2001). Risk factors for severe pulmonary and disseminated coccidioidomycosis: Kern County, California, 1995-1996. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 32(5), 708-15.
Rosenstein NE, et al. Risk Factors for Severe Pulmonary and Disseminated Coccidioidomycosis: Kern County, California, 1995-1996. Clin Infect Dis. 2001 Mar 1;32(5):708-15. PubMed PMID: 11229838.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk factors for severe pulmonary and disseminated coccidioidomycosis: Kern County, California, 1995-1996. AU - Rosenstein,N E, AU - Emery,K W, AU - Werner,S B, AU - Kao,A, AU - Johnson,R, AU - Rogers,D, AU - Vugia,D, AU - Reingold,A, AU - Talbot,R, AU - Plikaytis,B D, AU - Perkins,B A, AU - Hajjeh,R A, Y1 - 2001/02/28/ PY - 2000/03/01/received PY - 2000/07/26/revised PY - 2001/3/7/pubmed PY - 2001/8/3/medline PY - 2001/3/7/entrez SP - 708 EP - 15 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin. Infect. Dis. VL - 32 IS - 5 N2 - Surveillance for coccidioidomycosis (CM) and a case-control study for risk factors among adults were conducted in Kern County, California. From January 1995 through December 1996, 905 cases of CM were identified, for an annual incidence of 86 cases per 100,000 population. A total of 380 adults were enrolled in the case-control study: 77 had severe pulmonary disease, 33 had disseminated disease, and 270 control patients had mild disease. Independent risk factors for severe pulmonary disease included diabetes, recent history of cigarette smoking, income of < $15,000 per year, and older age. Oral antifungal therapy before hospitalization was associated with a reduced risk of CM pneumonia. Risk factors for disseminated disease were black race, income of < $15,000 per year, and pregnancy. Early treatment of CM with oral antifungal agents may prevent severe pulmonary disease in groups considered to be at high risk, such as elderly individuals, persons with diabetes, and smokers. Persons at risk for severe CM may benefit from vaccination once an effective CM vaccine is available. SN - 1058-4838 UR - https://www.unboundmedicine.com/medline/citation/11229838/full_citation L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/319203 DB - PRIME DP - Unbound Medicine ER -