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Altered control of cortisol secretion in adult men with low birth weight and cardiovascular risk factors.
J Clin Endocrinol Metab. 2001 Jan; 86(1):245-50.JC

Abstract

It has been suggested that increased activity of the hypothalamic-pituitary-adrenal axis may link low birth weight with subsequent development of cardiovascular risk factors and disease. Two hundred and five men, aged 66-77 yr, who were born and still live in East Hertfordshire underwent an overnight very low dose (0.25 mg) dexamethasone suppression test followed by a low dose 1-microgram ACTH-(1-24) stimulation test. A 24-h urine sample was collected for analysis of cortisol metabolites by gas chromatography/electron impact mass spectrometry. Men with lower birth weight had enhanced responses of plasma cortisol to ACTH-(1-24) (P = 0.03), increased total urinary cortisol metabolite excretion (after adjustment for confounding effects of increased obesity and lean body mass in high birth weight men; P = 0.04), but no difference in plasma cortisol after dexamethasone. Features of the metabolic syndrome were independently associated with enhanced adrenal responsiveness to ACTH-(1-24) (raised blood pressure, P = 0.02; glucose intolerance, P = 0.09; hypertriglyceridemia, P = 0.02), with trends to increased urinary cortisol metabolite excretion, but not with differences in plasma cortisol after dexamethasone. Men with low birth weight and/or the metabolic syndrome have increased activity of the hypothalamic-pituitary-adrenal axis. This may be an important mechanism underpinning the effects of events in early life on later cardiovascular disease.

Authors+Show Affiliations

Medical Research Council Environmental Epidemiology Unit, University of Southampton, United Kingdom. r.reynolds@ed.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11232008

Citation

Reynolds, R M., et al. "Altered Control of Cortisol Secretion in Adult Men With Low Birth Weight and Cardiovascular Risk Factors." The Journal of Clinical Endocrinology and Metabolism, vol. 86, no. 1, 2001, pp. 245-50.
Reynolds RM, Walker BR, Syddall HE, et al. Altered control of cortisol secretion in adult men with low birth weight and cardiovascular risk factors. J Clin Endocrinol Metab. 2001;86(1):245-50.
Reynolds, R. M., Walker, B. R., Syddall, H. E., Andrew, R., Wood, P. J., Whorwood, C. B., & Phillips, D. I. (2001). Altered control of cortisol secretion in adult men with low birth weight and cardiovascular risk factors. The Journal of Clinical Endocrinology and Metabolism, 86(1), 245-50.
Reynolds RM, et al. Altered Control of Cortisol Secretion in Adult Men With Low Birth Weight and Cardiovascular Risk Factors. J Clin Endocrinol Metab. 2001;86(1):245-50. PubMed PMID: 11232008.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Altered control of cortisol secretion in adult men with low birth weight and cardiovascular risk factors. AU - Reynolds,R M, AU - Walker,B R, AU - Syddall,H E, AU - Andrew,R, AU - Wood,P J, AU - Whorwood,C B, AU - Phillips,D I, PY - 2001/3/7/pubmed PY - 2001/4/17/medline PY - 2001/3/7/entrez SP - 245 EP - 50 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 86 IS - 1 N2 - It has been suggested that increased activity of the hypothalamic-pituitary-adrenal axis may link low birth weight with subsequent development of cardiovascular risk factors and disease. Two hundred and five men, aged 66-77 yr, who were born and still live in East Hertfordshire underwent an overnight very low dose (0.25 mg) dexamethasone suppression test followed by a low dose 1-microgram ACTH-(1-24) stimulation test. A 24-h urine sample was collected for analysis of cortisol metabolites by gas chromatography/electron impact mass spectrometry. Men with lower birth weight had enhanced responses of plasma cortisol to ACTH-(1-24) (P = 0.03), increased total urinary cortisol metabolite excretion (after adjustment for confounding effects of increased obesity and lean body mass in high birth weight men; P = 0.04), but no difference in plasma cortisol after dexamethasone. Features of the metabolic syndrome were independently associated with enhanced adrenal responsiveness to ACTH-(1-24) (raised blood pressure, P = 0.02; glucose intolerance, P = 0.09; hypertriglyceridemia, P = 0.02), with trends to increased urinary cortisol metabolite excretion, but not with differences in plasma cortisol after dexamethasone. Men with low birth weight and/or the metabolic syndrome have increased activity of the hypothalamic-pituitary-adrenal axis. This may be an important mechanism underpinning the effects of events in early life on later cardiovascular disease. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/11232008/Altered_control_of_cortisol_secretion_in_adult_men_with_low_birth_weight_and_cardiovascular_risk_factors_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jcem.86.1.7145 DB - PRIME DP - Unbound Medicine ER -