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Osteopenia and osteoporosis in Crohn's disease: prevalence in a Dutch population-based cohort.

Abstract

Reduced bone mineral density (BMD) has been reported in 3-77% of patients with inflammatory bowel disease (IBD). The majority of these studies are cross-sectional and from tertiary referral centres. The aim of our study was to estimate the prevalence of metabolic bone disease and of symptomatic fractures in a population of patients with Crohn's disease (CD) living in a well-defined geographic area. Patients with CD living in three adjacent municipalities within the IBD South-Limburg study area were investigated. BMD was measured by dual X-ray absorptiometry (DXA) of the femoral neck, lumbar spine and total body. The population comprised of 181 CD patients, 23 of whom were excluded. One-hundred-and-nineteen (75%) of the 158 eligible patients (37 males, 82 females with a mean age of 42 years (17-78)) were investigated. Osteopenia of lumbar spine and/or femoral neck was found in 45% of patients. Osteoporosis was found in another 13% of patients. Mean BMD (T-score) of femoral neck was significantly lower than of lumbar spine (P < 0.001). Male CD patients and patients aged under 18 at diagnosis are more at risk of having a low bone mass at the lumbar spine (P < 0.001) and total body (P = 0.018). The prevalence of osteoporosis in postmenopausal CD patients (29%) was significantly higher than in premenopausal patients (3%) (odds ratio: 12). Twenty-nine of 119 (24%) patients had a history of symptomatic fractures. Osteopenia and osteoporosis are frequent in CD and should have the full attention of the treating physician.

Authors+Show Affiliations

Dept. of Gastroenterology-Hepatology, University Hospital Maastricht, P.O. Box 5800, NL- 6202 AZ, Maastricht, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

11232491

Citation

Schoon, E J., et al. "Osteopenia and Osteoporosis in Crohn's Disease: Prevalence in a Dutch Population-based Cohort." Scandinavian Journal of Gastroenterology. Supplement, 2000, pp. 43-7.
Schoon EJ, van Nunen AB, Wouters RS, et al. Osteopenia and osteoporosis in Crohn's disease: prevalence in a Dutch population-based cohort. Scand J Gastroenterol Suppl. 2000.
Schoon, E. J., van Nunen, A. B., Wouters, R. S., Stockbrügger, R. W., & Russel, M. G. (2000). Osteopenia and osteoporosis in Crohn's disease: prevalence in a Dutch population-based cohort. Scandinavian Journal of Gastroenterology. Supplement, (232), 43-7.
Schoon EJ, et al. Osteopenia and Osteoporosis in Crohn's Disease: Prevalence in a Dutch Population-based Cohort. Scand J Gastroenterol Suppl. 2000;(232)43-7. PubMed PMID: 11232491.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Osteopenia and osteoporosis in Crohn's disease: prevalence in a Dutch population-based cohort. AU - Schoon,E J, AU - van Nunen,A B, AU - Wouters,R S, AU - Stockbrügger,R W, AU - Russel,M G, PY - 2001/3/10/pubmed PY - 2001/5/25/medline PY - 2001/3/10/entrez SP - 43 EP - 7 JF - Scandinavian journal of gastroenterology. Supplement JO - Scand. J. Gastroenterol. Suppl. IS - 232 N2 - Reduced bone mineral density (BMD) has been reported in 3-77% of patients with inflammatory bowel disease (IBD). The majority of these studies are cross-sectional and from tertiary referral centres. The aim of our study was to estimate the prevalence of metabolic bone disease and of symptomatic fractures in a population of patients with Crohn's disease (CD) living in a well-defined geographic area. Patients with CD living in three adjacent municipalities within the IBD South-Limburg study area were investigated. BMD was measured by dual X-ray absorptiometry (DXA) of the femoral neck, lumbar spine and total body. The population comprised of 181 CD patients, 23 of whom were excluded. One-hundred-and-nineteen (75%) of the 158 eligible patients (37 males, 82 females with a mean age of 42 years (17-78)) were investigated. Osteopenia of lumbar spine and/or femoral neck was found in 45% of patients. Osteoporosis was found in another 13% of patients. Mean BMD (T-score) of femoral neck was significantly lower than of lumbar spine (P < 0.001). Male CD patients and patients aged under 18 at diagnosis are more at risk of having a low bone mass at the lumbar spine (P < 0.001) and total body (P = 0.018). The prevalence of osteoporosis in postmenopausal CD patients (29%) was significantly higher than in premenopausal patients (3%) (odds ratio: 12). Twenty-nine of 119 (24%) patients had a history of symptomatic fractures. Osteopenia and osteoporosis are frequent in CD and should have the full attention of the treating physician. SN - 0085-5928 UR - https://www.unboundmedicine.com/medline/citation/11232491/Osteopenia_and_osteoporosis_in_Crohn's_disease:_prevalence_in_a_Dutch_population_based_cohort_ L2 - http://www.diseaseinfosearch.org/result/2013 DB - PRIME DP - Unbound Medicine ER -