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[Incidence and timing of thyroid dysfunction with long-term amiodarone therapy].
Arch Mal Coeur Vaiss. 2001 Jan; 94(1):39-43.AM

Abstract

The aim of this retrospective study was to assess the incidence, timing and classical presentations of thyroid dysfunction in patients treated long-term with amiodarone. Ninety patients (sex ratio M/W 67/33, mean age 71 years) were followed up for 48 months. The daily dose of amiodarone was 200 mg after loading doses during the hospital stay for atrial fibrillation. The average treatment period was 33 +/- 19 months. Hypothyroidism, observed in 5.5% of cases, occurred at variable intervals with few clinical manifestations. Hyperthyroidism was more common (12.2%), occurred increasingly with time, and was clinically symptomatic with recurrent supraventricular arrhythmias in 36% of cases. Long-term amiodarone therapy causes undesirable thyroid side-effects for nearly 1 out of 5 patients. Hyperthyroidism is more common than hypothyroidism and may be explained by increased iodine intake. The increasing incidence of hyperthyroidism with time suggests a cumulated dose relationship, a situation which is not observed with hypothyroidism.

Authors+Show Affiliations

Rouleau F
Service de cardiologie, CHU d'Angers, rue Larrey, 49000 Angers.
Baudusseau O
No affiliation info available
Dupuis JM
No affiliation info available
Victor J
No affiliation info available
Geslin P
No affiliation info available

MeSH

AdultAgedAged, 80 and overAmiodaroneAnti-Arrhythmia AgentsDrug Administration ScheduleFemaleHumansHyperthyroidismHypothyroidismIncidenceMaleMiddle Aged

Pub Type(s)

English Abstract
Journal Article

Language

fre

PubMed ID

11233479

Citation

Rouleau, F, et al. "[Incidence and Timing of Thyroid Dysfunction With Long-term Amiodarone Therapy]." Archives Des Maladies Du Coeur Et Des Vaisseaux, vol. 94, no. 1, 2001, pp. 39-43.
Rouleau F, Baudusseau O, Dupuis JM, et al. [Incidence and timing of thyroid dysfunction with long-term amiodarone therapy]. Arch Mal Coeur Vaiss. 2001;94(1):39-43.
Rouleau, F., Baudusseau, O., Dupuis, J. M., Victor, J., & Geslin, P. (2001). [Incidence and timing of thyroid dysfunction with long-term amiodarone therapy]. Archives Des Maladies Du Coeur Et Des Vaisseaux, 94(1), 39-43.
Rouleau F, et al. [Incidence and Timing of Thyroid Dysfunction With Long-term Amiodarone Therapy]. Arch Mal Coeur Vaiss. 2001;94(1):39-43. PubMed PMID: 11233479.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Incidence and timing of thyroid dysfunction with long-term amiodarone therapy]. AU - Rouleau,F, AU - Baudusseau,O, AU - Dupuis,J M, AU - Victor,J, AU - Geslin,P, PY - 2001/3/10/pubmed PY - 2001/4/3/medline PY - 2001/3/10/entrez SP - 39 EP - 43 JF - Archives des maladies du coeur et des vaisseaux JO - Arch Mal Coeur Vaiss VL - 94 IS - 1 N2 - The aim of this retrospective study was to assess the incidence, timing and classical presentations of thyroid dysfunction in patients treated long-term with amiodarone. Ninety patients (sex ratio M/W 67/33, mean age 71 years) were followed up for 48 months. The daily dose of amiodarone was 200 mg after loading doses during the hospital stay for atrial fibrillation. The average treatment period was 33 +/- 19 months. Hypothyroidism, observed in 5.5% of cases, occurred at variable intervals with few clinical manifestations. Hyperthyroidism was more common (12.2%), occurred increasingly with time, and was clinically symptomatic with recurrent supraventricular arrhythmias in 36% of cases. Long-term amiodarone therapy causes undesirable thyroid side-effects for nearly 1 out of 5 patients. Hyperthyroidism is more common than hypothyroidism and may be explained by increased iodine intake. The increasing incidence of hyperthyroidism with time suggests a cumulated dose relationship, a situation which is not observed with hypothyroidism. SN - 0003-9683 UR - https://www.unboundmedicine.com/medline/citation/11233479/[Incidence_and_timing_of_thyroid_dysfunction_with_long_term_amiodarone_therapy]_ DB - PRIME DP - Unbound Medicine ER -