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Antithrombotic and antineoplastic effects of phyto-organosulfur compounds.
Biofactors 2000; 13(1-4):251-5B

Abstract

The antiplatelet activity of methyl allyltrisulfide (MATS), a component commonly present in steam-distilled garlic oil, has been demonstrated by the authors. MATS inhibits arachidonic acid cascade at the reaction site with PGH synthase. However, this enzyme catalyzes two successive reactions, from arachidonic acid to PGG2, and from PGG2 to PGH2. The present study revealed that MATS inhibited the latter reaction. In addition, our recent findings that to a promyelocytic leukemia cell HL60, Allium oils shows marked anti-neoplastic effects representing both growth suppression and differentiation activities are described. The garlic oil and onion oil showed almost equal ability in inducing the proliferation, which measured either by nitroblue-tetrazolium reducing activity assay or by flow cytometry for detecting CD11b expression. The combination use of one of these oils with all-trans retinoic acid or with dimethyl sulfoxide lead to the marked differentiation of the cells, and their effects were estimated to be synergistic.

Authors+Show Affiliations

Department of Biochemical and Agricultural Chemistry, Nihon University College of Bioresource Sciences, Fujisawa, Kanagawa, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11237190

Citation

Ariga, T, et al. "Antithrombotic and Antineoplastic Effects of Phyto-organosulfur Compounds." BioFactors (Oxford, England), vol. 13, no. 1-4, 2000, pp. 251-5.
Ariga T, Tsuj K, Seki T, et al. Antithrombotic and antineoplastic effects of phyto-organosulfur compounds. Biofactors. 2000;13(1-4):251-5.
Ariga, T., Tsuj, K., Seki, T., Moritomo, T., & Yamamoto, J. I. (2000). Antithrombotic and antineoplastic effects of phyto-organosulfur compounds. BioFactors (Oxford, England), 13(1-4), pp. 251-5.
Ariga T, et al. Antithrombotic and Antineoplastic Effects of Phyto-organosulfur Compounds. Biofactors. 2000;13(1-4):251-5. PubMed PMID: 11237190.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antithrombotic and antineoplastic effects of phyto-organosulfur compounds. AU - Ariga,T, AU - Tsuj,K, AU - Seki,T, AU - Moritomo,T, AU - Yamamoto,J I, PY - 2001/3/10/pubmed PY - 2001/6/19/medline PY - 2001/3/10/entrez SP - 251 EP - 5 JF - BioFactors (Oxford, England) JO - Biofactors VL - 13 IS - 1-4 N2 - The antiplatelet activity of methyl allyltrisulfide (MATS), a component commonly present in steam-distilled garlic oil, has been demonstrated by the authors. MATS inhibits arachidonic acid cascade at the reaction site with PGH synthase. However, this enzyme catalyzes two successive reactions, from arachidonic acid to PGG2, and from PGG2 to PGH2. The present study revealed that MATS inhibited the latter reaction. In addition, our recent findings that to a promyelocytic leukemia cell HL60, Allium oils shows marked anti-neoplastic effects representing both growth suppression and differentiation activities are described. The garlic oil and onion oil showed almost equal ability in inducing the proliferation, which measured either by nitroblue-tetrazolium reducing activity assay or by flow cytometry for detecting CD11b expression. The combination use of one of these oils with all-trans retinoic acid or with dimethyl sulfoxide lead to the marked differentiation of the cells, and their effects were estimated to be synergistic. SN - 0951-6433 UR - https://www.unboundmedicine.com/medline/citation/11237190/Antithrombotic_and_antineoplastic_effects_of_phyto_organosulfur_compounds_ L2 - https://content.iospress.com/openurl?genre=article&issn=0951-6433&volume=13&issue=1-4&spage=251 DB - PRIME DP - Unbound Medicine ER -