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Soybean isoflavones dose-dependently reduce bone turnover but do not reverse established osteopenia in adult ovariectomized rats.
J Nutr. 2001 Mar; 131(3):723-8.JN

Abstract

We assessed the dose-dependent effects of daily soybean isoflavone (IF) consumption in reversing bone loss in adult ovariectomized rats. On d 0, female Wistar rats (7 mo old; n = 55) were either sham-operated (SH; n = 14) or ovariectomized (n = 41). On d 80, intermediate rats (SH: n = 5; ovariectomized: n = 5) were killed to confirm the ovariectomy-induced bone loss. The remaining ovariectomized rats were randomly assigned to one of four groups of nine rats each and fed soybean IF (mixed with a soy protein-free semipurified diet) at 0 (OVX), 20 (IF20), 40 (IF40) or 80 (IF80) mg/(kg body. d) for 84 d. Simultaneously, SH rats were fed the semipurified diet without any additional compound and killed on d 164, as were the other rats. As expected, both bone mineral density in the total femur and in its diaphyseal and metaphyseal subregions and cancellous bone area/measured surface in the distal femur metaphysis were lower in OVX than in SH rats (P: < 0.05). OVX rats had higher plasma osteocalcin concentration and urinary deoxypyridinoline excretion than SH rats (P: < 0.05). On d 164, osteocalcin and deoxypyridinoline concentrations were lower in IF40 or IF80 rats than in OVX rats (P: < 0.05). Nevertheless, neither bone mineral density nor cancellous bone area was greater in IF-fed rats than in OVX rats. Therefore, in adult ovariectomized rats, daily soybean IF consumption decreased bone turnover but did not reverse established osteopenia.

Authors+Show Affiliations

Groupe Ostéoporose, Laboratoire des Maladies Métaboliques et Micronutriments, Institut National de la Recherche Agronomigue Clermont-Ferrand/Theix, 63122 Saint Genès Champanelle, France. picherit@clermont.inra.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11238750

Citation

Picherit, C, et al. "Soybean Isoflavones Dose-dependently Reduce Bone Turnover but Do Not Reverse Established Osteopenia in Adult Ovariectomized Rats." The Journal of Nutrition, vol. 131, no. 3, 2001, pp. 723-8.
Picherit C, Bennetau-Pelissero C, Chanteranne B, et al. Soybean isoflavones dose-dependently reduce bone turnover but do not reverse established osteopenia in adult ovariectomized rats. J Nutr. 2001;131(3):723-8.
Picherit, C., Bennetau-Pelissero, C., Chanteranne, B., Lebecque, P., Davicco, M. J., Barlet, J. P., & Coxam, V. (2001). Soybean isoflavones dose-dependently reduce bone turnover but do not reverse established osteopenia in adult ovariectomized rats. The Journal of Nutrition, 131(3), 723-8.
Picherit C, et al. Soybean Isoflavones Dose-dependently Reduce Bone Turnover but Do Not Reverse Established Osteopenia in Adult Ovariectomized Rats. J Nutr. 2001;131(3):723-8. PubMed PMID: 11238750.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Soybean isoflavones dose-dependently reduce bone turnover but do not reverse established osteopenia in adult ovariectomized rats. AU - Picherit,C, AU - Bennetau-Pelissero,C, AU - Chanteranne,B, AU - Lebecque,P, AU - Davicco,M J, AU - Barlet,J P, AU - Coxam,V, PY - 2001/3/10/pubmed PY - 2001/4/21/medline PY - 2001/3/10/entrez SP - 723 EP - 8 JF - The Journal of nutrition JO - J. Nutr. VL - 131 IS - 3 N2 - We assessed the dose-dependent effects of daily soybean isoflavone (IF) consumption in reversing bone loss in adult ovariectomized rats. On d 0, female Wistar rats (7 mo old; n = 55) were either sham-operated (SH; n = 14) or ovariectomized (n = 41). On d 80, intermediate rats (SH: n = 5; ovariectomized: n = 5) were killed to confirm the ovariectomy-induced bone loss. The remaining ovariectomized rats were randomly assigned to one of four groups of nine rats each and fed soybean IF (mixed with a soy protein-free semipurified diet) at 0 (OVX), 20 (IF20), 40 (IF40) or 80 (IF80) mg/(kg body. d) for 84 d. Simultaneously, SH rats were fed the semipurified diet without any additional compound and killed on d 164, as were the other rats. As expected, both bone mineral density in the total femur and in its diaphyseal and metaphyseal subregions and cancellous bone area/measured surface in the distal femur metaphysis were lower in OVX than in SH rats (P: < 0.05). OVX rats had higher plasma osteocalcin concentration and urinary deoxypyridinoline excretion than SH rats (P: < 0.05). On d 164, osteocalcin and deoxypyridinoline concentrations were lower in IF40 or IF80 rats than in OVX rats (P: < 0.05). Nevertheless, neither bone mineral density nor cancellous bone area was greater in IF-fed rats than in OVX rats. Therefore, in adult ovariectomized rats, daily soybean IF consumption decreased bone turnover but did not reverse established osteopenia. SN - 0022-3166 UR - https://www.unboundmedicine.com/medline/citation/11238750/Soybean_isoflavones_dose_dependently_reduce_bone_turnover_but_do_not_reverse_established_osteopenia_in_adult_ovariectomized_rats_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.1093/jn/131.3.723 DB - PRIME DP - Unbound Medicine ER -