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A historical perspective on garlic and cancer.
J Nutr 2001; 131(3s):1027S-31SJN

Abstract

Epidemiological and laboratory studies provide insight into the anticarcinogenic potential of garlic and its constituent compounds. Both water- and lipid-soluble allyl sulfur compounds are effective in blocking a myriad of chemically induced tumors. Part of the protection from these compounds probably relates to a block in nitrosamine formation and metabolism. However, blockage in the initiation and promotion phases of the carcinogenicity of various compounds, including polycyclic hydrocarbons, provide evidence that garlic and its constituents can alter several phase I and II enzymes. Their ability to block experimentally induced tumors in a variety of sites including skin, mammary and colon, suggests a general mechanism of action. Changes in DNA repair and in immunocompetence may also account for some of this protection. Some, but not all, allyl sulfur compounds can also effectively retard tumor proliferation and induce apoptosis. Changes in cellular thiol and phosphorylation stains may account for some of these antitumorigenic properties. The anticarcinogenic potential of garlic can be influenced by several dietary components including specific fatty acids, selenium, and vitamin A. Since garlic and its constituents can suppress carcinogen formation, carcinogen bioactivation, and tumor proliferation it is imperative that biomarkers be established to identify which individuals might benefit most and what intakes can occur with ill consequences.

Authors+Show Affiliations

Nutrition Department, The Pennsylvania State University, University Park, PA 16802, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

11238810

Citation

Milner, J A.. "A Historical Perspective On Garlic and Cancer." The Journal of Nutrition, vol. 131, no. 3s, 2001, 1027S-31S.
Milner JA. A historical perspective on garlic and cancer. J Nutr. 2001;131(3s):1027S-31S.
Milner, J. A. (2001). A historical perspective on garlic and cancer. The Journal of Nutrition, 131(3s), 1027S-31S. doi:10.1093/jn/131.3.1027S.
Milner JA. A Historical Perspective On Garlic and Cancer. J Nutr. 2001;131(3s):1027S-31S. PubMed PMID: 11238810.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A historical perspective on garlic and cancer. A1 - Milner,J A, PY - 2001/3/10/pubmed PY - 2001/4/21/medline PY - 2001/3/10/entrez SP - 1027S EP - 31S JF - The Journal of nutrition JO - J. Nutr. VL - 131 IS - 3s N2 - Epidemiological and laboratory studies provide insight into the anticarcinogenic potential of garlic and its constituent compounds. Both water- and lipid-soluble allyl sulfur compounds are effective in blocking a myriad of chemically induced tumors. Part of the protection from these compounds probably relates to a block in nitrosamine formation and metabolism. However, blockage in the initiation and promotion phases of the carcinogenicity of various compounds, including polycyclic hydrocarbons, provide evidence that garlic and its constituents can alter several phase I and II enzymes. Their ability to block experimentally induced tumors in a variety of sites including skin, mammary and colon, suggests a general mechanism of action. Changes in DNA repair and in immunocompetence may also account for some of this protection. Some, but not all, allyl sulfur compounds can also effectively retard tumor proliferation and induce apoptosis. Changes in cellular thiol and phosphorylation stains may account for some of these antitumorigenic properties. The anticarcinogenic potential of garlic can be influenced by several dietary components including specific fatty acids, selenium, and vitamin A. Since garlic and its constituents can suppress carcinogen formation, carcinogen bioactivation, and tumor proliferation it is imperative that biomarkers be established to identify which individuals might benefit most and what intakes can occur with ill consequences. SN - 0022-3166 UR - https://www.unboundmedicine.com/medline/citation/11238810/full_citation L2 - https://academic.oup.com/jn/article-lookup/doi/10.1093/jn/131.3.1027S DB - PRIME DP - Unbound Medicine ER -