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Antiproliferative effects of allium derivatives from garlic.
J Nutr 2001; 131(3s):1058S-60SJN

Abstract

There is increasing evidence that allium derivatives from garlic have significant antiproliferative actions on human cancers. Both hormone-responsive and hormone-unresponsive cells lines respond to these derivatives. The effects shown by allium derivatives include induction of apoptosis, regulation of cell cycle progression and modification of pathways of signal transduction. Allium derivatives appear to regulate nuclear factors involved in immune function and inflammation, as well as in cellular proliferation. Our own studies indicate that allium derivatives inhibit proliferation of the human prostate cancer cell line (LNCaP) and the human breast cancer cell line (MCF-7). Further research is required to clarify the mechanisms of inhibition of cellular proliferation by allium derivatives and to explore their potential application to cancer prevention and control.

Authors+Show Affiliations

Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. pintoj@mskcc.orgNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

11238816

Citation

Pinto, J T., and R S. Rivlin. "Antiproliferative Effects of Allium Derivatives From Garlic." The Journal of Nutrition, vol. 131, no. 3s, 2001, 1058S-60S.
Pinto JT, Rivlin RS. Antiproliferative effects of allium derivatives from garlic. J Nutr. 2001;131(3s):1058S-60S.
Pinto, J. T., & Rivlin, R. S. (2001). Antiproliferative effects of allium derivatives from garlic. The Journal of Nutrition, 131(3s), 1058S-60S. doi:10.1093/jn/131.3.1058S.
Pinto JT, Rivlin RS. Antiproliferative Effects of Allium Derivatives From Garlic. J Nutr. 2001;131(3s):1058S-60S. PubMed PMID: 11238816.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antiproliferative effects of allium derivatives from garlic. AU - Pinto,J T, AU - Rivlin,R S, PY - 2001/3/10/pubmed PY - 2001/4/21/medline PY - 2001/3/10/entrez SP - 1058S EP - 60S JF - The Journal of nutrition JO - J. Nutr. VL - 131 IS - 3s N2 - There is increasing evidence that allium derivatives from garlic have significant antiproliferative actions on human cancers. Both hormone-responsive and hormone-unresponsive cells lines respond to these derivatives. The effects shown by allium derivatives include induction of apoptosis, regulation of cell cycle progression and modification of pathways of signal transduction. Allium derivatives appear to regulate nuclear factors involved in immune function and inflammation, as well as in cellular proliferation. Our own studies indicate that allium derivatives inhibit proliferation of the human prostate cancer cell line (LNCaP) and the human breast cancer cell line (MCF-7). Further research is required to clarify the mechanisms of inhibition of cellular proliferation by allium derivatives and to explore their potential application to cancer prevention and control. SN - 0022-3166 UR - https://www.unboundmedicine.com/medline/citation/11238816/Antiproliferative_effects_of_allium_derivatives_from_garlic_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.1093/jn/131.3.1058S DB - PRIME DP - Unbound Medicine ER -