Tags

Type your tag names separated by a space and hit enter

Possible mechanism by which allyl sulfides suppress neoplastic cell proliferation.
J Nutr 2001; 131(3s):1061S-6SJN

Abstract

Both oil- and water-soluble allyl sulfur compounds from garlic have been found to possess antitumorigenic properties. These antitumorigenic properties increase as exposure increases both in vitro and in vivo. Generally, oil-soluble allyl sulfur compounds are more effective antiproliferative agents than their water-soluble counterparts. The ability of these compounds to suppress proliferation is associated with a depression in cell cycle progression and the induction of apoptosis. This depression in cell division coincides with an increase in the percentage of cells blocked in the G(2)/M phase of the cell cycle. A depression in p34(cdc2) kinase may account for this blockage in cell division.

Authors+Show Affiliations

Graduate Program in Nutrition and the Nutrition Department, The Pennsylvania State University, University Park, PA 16802, USA.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

11238817

Citation

Knowles, L M., and J A. Milner. "Possible Mechanism By Which Allyl Sulfides Suppress Neoplastic Cell Proliferation." The Journal of Nutrition, vol. 131, no. 3s, 2001, 1061S-6S.
Knowles LM, Milner JA. Possible mechanism by which allyl sulfides suppress neoplastic cell proliferation. J Nutr. 2001;131(3s):1061S-6S.
Knowles, L. M., & Milner, J. A. (2001). Possible mechanism by which allyl sulfides suppress neoplastic cell proliferation. The Journal of Nutrition, 131(3s), 1061S-6S. doi:10.1093/jn/131.3.1061S.
Knowles LM, Milner JA. Possible Mechanism By Which Allyl Sulfides Suppress Neoplastic Cell Proliferation. J Nutr. 2001;131(3s):1061S-6S. PubMed PMID: 11238817.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Possible mechanism by which allyl sulfides suppress neoplastic cell proliferation. AU - Knowles,L M, AU - Milner,J A, PY - 2001/3/10/pubmed PY - 2001/4/21/medline PY - 2001/3/10/entrez SP - 1061S EP - 6S JF - The Journal of nutrition JO - J. Nutr. VL - 131 IS - 3s N2 - Both oil- and water-soluble allyl sulfur compounds from garlic have been found to possess antitumorigenic properties. These antitumorigenic properties increase as exposure increases both in vitro and in vivo. Generally, oil-soluble allyl sulfur compounds are more effective antiproliferative agents than their water-soluble counterparts. The ability of these compounds to suppress proliferation is associated with a depression in cell cycle progression and the induction of apoptosis. This depression in cell division coincides with an increase in the percentage of cells blocked in the G(2)/M phase of the cell cycle. A depression in p34(cdc2) kinase may account for this blockage in cell division. SN - 0022-3166 UR - https://www.unboundmedicine.com/medline/citation/11238817/Possible_mechanism_by_which_allyl_sulfides_suppress_neoplastic_cell_proliferation_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.1093/jn/131.3.1061S DB - PRIME DP - Unbound Medicine ER -