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Low HDL-cholesterol: a component of the metabolic syndrome only in the presence of fasting hypertriglyceridemia in type 2 diabetic patients.
Diabetes Metab 2001; 27(1):31-5DM

Abstract

The relation between isolated low HDL-cholesterol and the components of the metabolic syndrome is poorly known in type 2 diabetes. We evaluated cardiovascular risk parameters in type 2 diabetic patients with low HDL-cholesterol, compared to those with low HDL-cholesterol and hypertriglyceridemia, isolated hypertriglyceridemia and normal lipid parameters. Patients with low HDL-cholesterol/high triglycerides had higher BMI (29.6 +/- 5.7 vs 27.9 +/- 4.4 or vs 28.1 +/- 5.2 kg/m(2)), prevalence of obesity (69% vs 55% or vs 54%), higher levels of uric acid (339.0 +/- 83.3 vs 303.3 +/- 95.2 or vs 303.3 +/- 89.2 micromol/l) and C-peptide (0.76 +/- 0.40 vs 0.63 +/- 0.33 or vs 0.63 +/- 0.36 nmol/l) and number of components of the metabolic syndrome (27% patients with all the components) compared to patients with isolated low HDL-cholesterol or normal subjects, respectively. A similar pattern of values was evident in patients with isolated hypertriglyceridemia. With logistic regression analysis, BMI and uric acid levels were significantly associated with the presence of hypertriglyceridemia (both isolated or associated with low HDL-cholesterol), while patients with isolated low HDL-cholesterol and those without dyslipidemia displayed a similar more favourable metabolic pattern. These results indicate that low HDL-cholesterol is a component of the metabolic syndrome only in the presence of fasting hypertriglyceridemia in type 2 diabetic patients.

Authors+Show Affiliations

Department of Internal Medicine, University of Torino, Torino, Italy. pagano@molinette.unito.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

11240443

Citation

Bo, S, et al. "Low HDL-cholesterol: a Component of the Metabolic Syndrome Only in the Presence of Fasting Hypertriglyceridemia in Type 2 Diabetic Patients." Diabetes & Metabolism, vol. 27, no. 1, 2001, pp. 31-5.
Bo S, Cavallo-Perin P, Gentile L, et al. Low HDL-cholesterol: a component of the metabolic syndrome only in the presence of fasting hypertriglyceridemia in type 2 diabetic patients. Diabetes Metab. 2001;27(1):31-5.
Bo, S., Cavallo-Perin, P., Gentile, L., Repetti, E., & Pagano, G. (2001). Low HDL-cholesterol: a component of the metabolic syndrome only in the presence of fasting hypertriglyceridemia in type 2 diabetic patients. Diabetes & Metabolism, 27(1), pp. 31-5.
Bo S, et al. Low HDL-cholesterol: a Component of the Metabolic Syndrome Only in the Presence of Fasting Hypertriglyceridemia in Type 2 Diabetic Patients. Diabetes Metab. 2001;27(1):31-5. PubMed PMID: 11240443.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low HDL-cholesterol: a component of the metabolic syndrome only in the presence of fasting hypertriglyceridemia in type 2 diabetic patients. AU - Bo,S, AU - Cavallo-Perin,P, AU - Gentile,L, AU - Repetti,E, AU - Pagano,G, PY - 2001/3/10/pubmed PY - 2001/5/5/medline PY - 2001/3/10/entrez SP - 31 EP - 5 JF - Diabetes & metabolism JO - Diabetes Metab. VL - 27 IS - 1 N2 - The relation between isolated low HDL-cholesterol and the components of the metabolic syndrome is poorly known in type 2 diabetes. We evaluated cardiovascular risk parameters in type 2 diabetic patients with low HDL-cholesterol, compared to those with low HDL-cholesterol and hypertriglyceridemia, isolated hypertriglyceridemia and normal lipid parameters. Patients with low HDL-cholesterol/high triglycerides had higher BMI (29.6 +/- 5.7 vs 27.9 +/- 4.4 or vs 28.1 +/- 5.2 kg/m(2)), prevalence of obesity (69% vs 55% or vs 54%), higher levels of uric acid (339.0 +/- 83.3 vs 303.3 +/- 95.2 or vs 303.3 +/- 89.2 micromol/l) and C-peptide (0.76 +/- 0.40 vs 0.63 +/- 0.33 or vs 0.63 +/- 0.36 nmol/l) and number of components of the metabolic syndrome (27% patients with all the components) compared to patients with isolated low HDL-cholesterol or normal subjects, respectively. A similar pattern of values was evident in patients with isolated hypertriglyceridemia. With logistic regression analysis, BMI and uric acid levels were significantly associated with the presence of hypertriglyceridemia (both isolated or associated with low HDL-cholesterol), while patients with isolated low HDL-cholesterol and those without dyslipidemia displayed a similar more favourable metabolic pattern. These results indicate that low HDL-cholesterol is a component of the metabolic syndrome only in the presence of fasting hypertriglyceridemia in type 2 diabetic patients. SN - 1262-3636 UR - https://www.unboundmedicine.com/medline/citation/11240443/Low_HDL_cholesterol:_a_component_of_the_metabolic_syndrome_only_in_the_presence_of_fasting_hypertriglyceridemia_in_type_2_diabetic_patients_ L2 - https://medlineplus.gov/triglycerides.html DB - PRIME DP - Unbound Medicine ER -