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Divergent changes in serum sterols during a strict uncooked vegan diet in patients with rheumatoid arthritis.
Br J Nutr 2001; 85(2):137-9BJ

Abstract

The effects of a strict uncooked vegan diet on serum lipid and sterol concentrations were studied in patients with rheumatoid arthritis. The subjects were randomized into a vegan diet group (n 16), who consumed a vegan diet for 2-3 months, or into a control group (n 13), who continued their usual omnivorous diets. Serum total and LDL-cholesterol and -phospholipid concentrations were significantly decreased by the vegan diet. The levels of serum cholestanol and lathosterol also decreased, but serum cholestanol:total cholesterol and lathosterol:total cholesterol did not change. The effect of a vegan diet on serum plant sterols was divergent as the concentration of campesterol decreased while that of sitosterol increased. This effect resulted in a significantly greater sitosterol:campesterol value in the vegan diet group than in the control group (1.48 (SD 0.39) v. 0.72 (SD 0.14); P < 0.001). A higher concentration of campesterol compared with sitosterol is normal in omnivorous subjects and can be explained by lower absorption and esterification rates of sitosterol. Our results suggest that a strict uncooked vegan diet changes the relative absorption rates of these sterols and/or their biliary clearance.

Authors+Show Affiliations

Department of Physiology, University of Kuopio, PO Box 1627, SF-70211 Kuopio, Finland. Jyrki.Agren@uku.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

11242480

Citation

Agren, J J., et al. "Divergent Changes in Serum Sterols During a Strict Uncooked Vegan Diet in Patients With Rheumatoid Arthritis." The British Journal of Nutrition, vol. 85, no. 2, 2001, pp. 137-9.
Agren JJ, Tvrzicka E, Nenonen MT, et al. Divergent changes in serum sterols during a strict uncooked vegan diet in patients with rheumatoid arthritis. Br J Nutr. 2001;85(2):137-9.
Agren, J. J., Tvrzicka, E., Nenonen, M. T., Helve, T., & Hänninen, O. (2001). Divergent changes in serum sterols during a strict uncooked vegan diet in patients with rheumatoid arthritis. The British Journal of Nutrition, 85(2), pp. 137-9.
Agren JJ, et al. Divergent Changes in Serum Sterols During a Strict Uncooked Vegan Diet in Patients With Rheumatoid Arthritis. Br J Nutr. 2001;85(2):137-9. PubMed PMID: 11242480.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Divergent changes in serum sterols during a strict uncooked vegan diet in patients with rheumatoid arthritis. AU - Agren,J J, AU - Tvrzicka,E, AU - Nenonen,M T, AU - Helve,T, AU - Hänninen,O, PY - 2001/3/10/pubmed PY - 2001/4/17/medline PY - 2001/3/10/entrez SP - 137 EP - 9 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 85 IS - 2 N2 - The effects of a strict uncooked vegan diet on serum lipid and sterol concentrations were studied in patients with rheumatoid arthritis. The subjects were randomized into a vegan diet group (n 16), who consumed a vegan diet for 2-3 months, or into a control group (n 13), who continued their usual omnivorous diets. Serum total and LDL-cholesterol and -phospholipid concentrations were significantly decreased by the vegan diet. The levels of serum cholestanol and lathosterol also decreased, but serum cholestanol:total cholesterol and lathosterol:total cholesterol did not change. The effect of a vegan diet on serum plant sterols was divergent as the concentration of campesterol decreased while that of sitosterol increased. This effect resulted in a significantly greater sitosterol:campesterol value in the vegan diet group than in the control group (1.48 (SD 0.39) v. 0.72 (SD 0.14); P < 0.001). A higher concentration of campesterol compared with sitosterol is normal in omnivorous subjects and can be explained by lower absorption and esterification rates of sitosterol. Our results suggest that a strict uncooked vegan diet changes the relative absorption rates of these sterols and/or their biliary clearance. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/11242480/Divergent_changes_in_serum_sterols_during_a_strict_uncooked_vegan_diet_in_patients_with_rheumatoid_arthritis_ L2 - http://www.diseaseinfosearch.org/result/592 DB - PRIME DP - Unbound Medicine ER -