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A histological study of gastric mucosa before and after proximal gastric vagotomy in duodenal ulcer patients.
Scand J Gastroenterol. 1975; 10(2):181-6.SJ

Abstract

In 29 patients with duodenal ulcer, suction biopsies were obtained from the body of the stomach within 2 weeks before and 3 and 12 months after proximal gastric vagotomy (PGV). Only those with a negative insulin test were included in the study. Three months after PGV basal and pentagastrin-stimulated acid secretion was reduced by 82 and 64 percent of preoperative values, respectively. Twelve months after the operation the corresponding figures were 63 and 56 percent. There was a similar acid reduction in patients with or without gastritis. The number of patients with atrophic gastritis increased from 3 before the operation to 11 3 months after PGV (p smaller than 0.01). There was no further increase from 3 to 12 months postoperatively. The average thickness of gastric mucosa and the mean number of parietal cells per unit area before PGV did not show any significant change 3 months and 1 year after the operation. There was a significant correlation between the number of parietal cells per unit area and maximal acid output before (p smaller than0.01) but not after PGV. Acid output per parietal cell was higher before PGV, suggesting that the decrease in gastric secretion after PGV cannot be attributed to the development of gastritis or reduction of parietal cell number.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1124352

Citation

Roland, M, et al. "A Histological Study of Gastric Mucosa Before and After Proximal Gastric Vagotomy in Duodenal Ulcer Patients." Scandinavian Journal of Gastroenterology, vol. 10, no. 2, 1975, pp. 181-6.
Roland M, Berstad A, Liavåg . A histological study of gastric mucosa before and after proximal gastric vagotomy in duodenal ulcer patients. Scand J Gastroenterol. 1975;10(2):181-6.
Roland, M., Berstad, A., & Liavåg, . (1975). A histological study of gastric mucosa before and after proximal gastric vagotomy in duodenal ulcer patients. Scandinavian Journal of Gastroenterology, 10(2), 181-6.
Roland M, Berstad A, Liavåg . A Histological Study of Gastric Mucosa Before and After Proximal Gastric Vagotomy in Duodenal Ulcer Patients. Scand J Gastroenterol. 1975;10(2):181-6. PubMed PMID: 1124352.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A histological study of gastric mucosa before and after proximal gastric vagotomy in duodenal ulcer patients. AU - Roland,M, AU - Berstad,A, AU - Liavåg,, PY - 1975/1/1/pubmed PY - 1975/1/1/medline PY - 1975/1/1/entrez SP - 181 EP - 6 JF - Scandinavian journal of gastroenterology JO - Scand J Gastroenterol VL - 10 IS - 2 N2 - In 29 patients with duodenal ulcer, suction biopsies were obtained from the body of the stomach within 2 weeks before and 3 and 12 months after proximal gastric vagotomy (PGV). Only those with a negative insulin test were included in the study. Three months after PGV basal and pentagastrin-stimulated acid secretion was reduced by 82 and 64 percent of preoperative values, respectively. Twelve months after the operation the corresponding figures were 63 and 56 percent. There was a similar acid reduction in patients with or without gastritis. The number of patients with atrophic gastritis increased from 3 before the operation to 11 3 months after PGV (p smaller than 0.01). There was no further increase from 3 to 12 months postoperatively. The average thickness of gastric mucosa and the mean number of parietal cells per unit area before PGV did not show any significant change 3 months and 1 year after the operation. There was a significant correlation between the number of parietal cells per unit area and maximal acid output before (p smaller than0.01) but not after PGV. Acid output per parietal cell was higher before PGV, suggesting that the decrease in gastric secretion after PGV cannot be attributed to the development of gastritis or reduction of parietal cell number. SN - 0036-5521 UR - https://www.unboundmedicine.com/medline/citation/1124352/A_histological_study_of_gastric_mucosa_before_and_after_proximal_gastric_vagotomy_in_duodenal_ulcer_patients_ DB - PRIME DP - Unbound Medicine ER -