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The serological and molecular epidemiology of GB virus C/hepatitis G virus infection in a hepatitis C and B endemic area.
J Infect. 2001 Jan; 42(1):61-6.JI

Abstract

OBJECTIVES

To investigate the serological and molecular characteristics of GB virus C/hepatitis G virus (GBV-C/HGV) infection in the hepatitis C virus (HCV)/hepatitis B virus (HBV)-endemic areas in Taiwan.

METHODS

Sera from 200 residents from Masago, an HCV/HBV-endemic community in Taiwan, and 400 blood donors were tested for GBV-C/HGV RNA by using nested reverse transcription-polymerase chain reaction and for antibodies to GBV-C/HGV E2-protein (anti-E2) by an enzyme-linked immunosorbent assay. Phylogenetic analysis of GBV-C/HGV was performed.

RESULTS

The prevalence of GBV-C/HGV viraemia, anti-E2 and GBV-C/HGV exposure among residents of Masago was significantly higher than that among donors (17.0%, 25.5% and 39.5% vs. 3.3%, 7.5% and 10.3%, respectively; all P < 0.0001). In Masago, the prevalence of GBV-C/HGV exposure was significantly higher in residents exposed to HCV than in those without HCV exposure (45.8% vs. 24.1%;P< 0.005). Based on multivariate analyses, HCV viraemia was the only significant factor associated with elevated levels of alanine aminotransferase in Masago. Phylogenetic analysis showed all 34 GBV-C/HGV isolates from Masago clustered within genotype 3.

CONCLUSIONS

GBV-C/HGV was highly prevalent in Masago, an HCV/HBV-endemic community in Taiwan. HCV viraemia played the most important clinical hepatopathic role in the area. Infections with other hepatitis viruses did not influence the anti-E2 seroconversion from GBV-C/HGV infections.

Authors+Show Affiliations

Hepatobiliary Division, Department of Internal Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11243756

Citation

Yu, M L., et al. "The Serological and Molecular Epidemiology of GB Virus C/hepatitis G Virus Infection in a Hepatitis C and B Endemic Area." The Journal of Infection, vol. 42, no. 1, 2001, pp. 61-6.
Yu ML, Chuang WL, Dai CY, et al. The serological and molecular epidemiology of GB virus C/hepatitis G virus infection in a hepatitis C and B endemic area. J Infect. 2001;42(1):61-6.
Yu, M. L., Chuang, W. L., Dai, C. Y., Lu, S. N., Wang, J. H., Huang, J. F., Chen, S. C., Lin, Z. Y., Hsieh, M. Y., Tsai, J. F., Wang, L. Y., & Chang, W. Y. (2001). The serological and molecular epidemiology of GB virus C/hepatitis G virus infection in a hepatitis C and B endemic area. The Journal of Infection, 42(1), 61-6.
Yu ML, et al. The Serological and Molecular Epidemiology of GB Virus C/hepatitis G Virus Infection in a Hepatitis C and B Endemic Area. J Infect. 2001;42(1):61-6. PubMed PMID: 11243756.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The serological and molecular epidemiology of GB virus C/hepatitis G virus infection in a hepatitis C and B endemic area. AU - Yu,M L, AU - Chuang,W L, AU - Dai,C Y, AU - Lu,S N, AU - Wang,J H, AU - Huang,J F, AU - Chen,S C, AU - Lin,Z Y, AU - Hsieh,M Y, AU - Tsai,J F, AU - Wang,L Y, AU - Chang,W Y, PY - 2001/3/13/pubmed PY - 2001/9/21/medline PY - 2001/3/13/entrez SP - 61 EP - 6 JF - The Journal of infection JO - J Infect VL - 42 IS - 1 N2 - OBJECTIVES: To investigate the serological and molecular characteristics of GB virus C/hepatitis G virus (GBV-C/HGV) infection in the hepatitis C virus (HCV)/hepatitis B virus (HBV)-endemic areas in Taiwan. METHODS: Sera from 200 residents from Masago, an HCV/HBV-endemic community in Taiwan, and 400 blood donors were tested for GBV-C/HGV RNA by using nested reverse transcription-polymerase chain reaction and for antibodies to GBV-C/HGV E2-protein (anti-E2) by an enzyme-linked immunosorbent assay. Phylogenetic analysis of GBV-C/HGV was performed. RESULTS: The prevalence of GBV-C/HGV viraemia, anti-E2 and GBV-C/HGV exposure among residents of Masago was significantly higher than that among donors (17.0%, 25.5% and 39.5% vs. 3.3%, 7.5% and 10.3%, respectively; all P < 0.0001). In Masago, the prevalence of GBV-C/HGV exposure was significantly higher in residents exposed to HCV than in those without HCV exposure (45.8% vs. 24.1%;P< 0.005). Based on multivariate analyses, HCV viraemia was the only significant factor associated with elevated levels of alanine aminotransferase in Masago. Phylogenetic analysis showed all 34 GBV-C/HGV isolates from Masago clustered within genotype 3. CONCLUSIONS: GBV-C/HGV was highly prevalent in Masago, an HCV/HBV-endemic community in Taiwan. HCV viraemia played the most important clinical hepatopathic role in the area. Infections with other hepatitis viruses did not influence the anti-E2 seroconversion from GBV-C/HGV infections. SN - 0163-4453 UR - https://www.unboundmedicine.com/medline/citation/11243756/The_serological_and_molecular_epidemiology_of_GB_virus_C/hepatitis_G_virus_infection_in_a_hepatitis_C_and_B_endemic_area_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0163-4453(00)90785-0 DB - PRIME DP - Unbound Medicine ER -