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Carotid intima-media thickness in relation to macrovascular disease in patients with type 2 diabetes mellitus.
Wien Klin Wochenschr 2000; 112(20):887-91WK

Abstract

BACKGROUND

Increased carotid intima-media thickness is regarded as a marker of atherosclerosis. Type 2 diabetes mellitus is associated with a high prevalence of macrovascular disease.

MAIN PURPOSE

The present study aimed to examine the relationship between carotid intima-media thickness and the presence of macrovascular disease in patients with type 2 diabetes.

METHODS

71 patients with type 2 diabetes mellitus were studied. The distal common carotid artery and carotid bifurcation intima-media thickness were measured bilaterally with high-resolution ultrasonography. The relationship between the presence of coronary artery disease, cerebrovascular disease and peripheral arterial disease and carotid intima-media thickness was evaluated.

RESULTS

Patients with coronary artery disease had significantly (p = 0.048) increased intima-media thickness of the distal common carotid artery. This difference ceased to be significant after adjustment for cardiovascular risk factors. Patients with peripheral arterial disease had a significantly higher bifurcation (p < 0.0001), distal common carotid (p = 0.03) and mean intima-media thickness (p = 0.0008) than did those without peripheral arterial disease. This difference remained significant even after adjustment for other cardiovascular risk factors. In the multiple linear regression analysis, the presence of peripheral arterial disease, age and male gender significantly predicted bifurcation intima-media thickness, while age and the presence of peripheral arterial disease significantly predicted mean intima-medial thickness.

CONCLUSIONS

In the present study, the increased carotid intima-media thickness in patients with type 2 diabetes mellitus was related to the presence of peripheral arterial disease. This finding probably reflects morphologic and hemodynamic similarities between the two vascular beds and indicates that increased carotid intima-media thickness in patients with type 2 diabetes may be a marker of atherosclerosis in different locations.

Authors+Show Affiliations

Department of Internal Medicine IV, Medical Faculty, P. J. Safárik University, Kosice, Slovak Republic.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11244615

Citation

Mudríková, T, et al. "Carotid Intima-media Thickness in Relation to Macrovascular Disease in Patients With Type 2 Diabetes Mellitus." Wiener Klinische Wochenschrift, vol. 112, no. 20, 2000, pp. 887-91.
Mudríková T, Szabová E, Tkác I. Carotid intima-media thickness in relation to macrovascular disease in patients with type 2 diabetes mellitus. Wien Klin Wochenschr. 2000;112(20):887-91.
Mudríková, T., Szabová, E., & Tkác, I. (2000). Carotid intima-media thickness in relation to macrovascular disease in patients with type 2 diabetes mellitus. Wiener Klinische Wochenschrift, 112(20), pp. 887-91.
Mudríková T, Szabová E, Tkác I. Carotid Intima-media Thickness in Relation to Macrovascular Disease in Patients With Type 2 Diabetes Mellitus. Wien Klin Wochenschr. 2000 Oct 27;112(20):887-91. PubMed PMID: 11244615.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Carotid intima-media thickness in relation to macrovascular disease in patients with type 2 diabetes mellitus. AU - Mudríková,T, AU - Szabová,E, AU - Tkác,I, PY - 2001/3/14/pubmed PY - 2001/5/1/medline PY - 2001/3/14/entrez SP - 887 EP - 91 JF - Wiener klinische Wochenschrift JO - Wien. Klin. Wochenschr. VL - 112 IS - 20 N2 - BACKGROUND: Increased carotid intima-media thickness is regarded as a marker of atherosclerosis. Type 2 diabetes mellitus is associated with a high prevalence of macrovascular disease. MAIN PURPOSE: The present study aimed to examine the relationship between carotid intima-media thickness and the presence of macrovascular disease in patients with type 2 diabetes. METHODS: 71 patients with type 2 diabetes mellitus were studied. The distal common carotid artery and carotid bifurcation intima-media thickness were measured bilaterally with high-resolution ultrasonography. The relationship between the presence of coronary artery disease, cerebrovascular disease and peripheral arterial disease and carotid intima-media thickness was evaluated. RESULTS: Patients with coronary artery disease had significantly (p = 0.048) increased intima-media thickness of the distal common carotid artery. This difference ceased to be significant after adjustment for cardiovascular risk factors. Patients with peripheral arterial disease had a significantly higher bifurcation (p < 0.0001), distal common carotid (p = 0.03) and mean intima-media thickness (p = 0.0008) than did those without peripheral arterial disease. This difference remained significant even after adjustment for other cardiovascular risk factors. In the multiple linear regression analysis, the presence of peripheral arterial disease, age and male gender significantly predicted bifurcation intima-media thickness, while age and the presence of peripheral arterial disease significantly predicted mean intima-medial thickness. CONCLUSIONS: In the present study, the increased carotid intima-media thickness in patients with type 2 diabetes mellitus was related to the presence of peripheral arterial disease. This finding probably reflects morphologic and hemodynamic similarities between the two vascular beds and indicates that increased carotid intima-media thickness in patients with type 2 diabetes may be a marker of atherosclerosis in different locations. SN - 0043-5325 UR - https://www.unboundmedicine.com/medline/citation/11244615/Carotid_intima_media_thickness_in_relation_to_macrovascular_disease_in_patients_with_type_2_diabetes_mellitus_ L2 - http://www.diseaseinfosearch.org/result/8215 DB - PRIME DP - Unbound Medicine ER -