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Activation products of the haemostatic system in coronary, cerebrovascular and peripheral arterial disease.
Thromb Haemost. 2001 Feb; 85(2):234-9.TH

Abstract

To determine the presence of a 'hypercoagulable state' as assessed by indices of thrombin and plasmin generation and of the amount of fibrin that is lysed, in patients with stable coronary, cerebral and peripheral arterial disease a population-based cross-sectional study was performed. From a population-based cohort comprising 7983 men and women aged 55 years and over, we randomly selected 127 subjects with a history of myocardial infarction, 124 with a history of stroke and/or transient ischemic attack, 131 patients with peripheral arterial disease and 263 control subjects in the same age group without arterial disease. Subjects using anticoagulant drugs were not selected. F1+2, TAT, and PAP were not associated with a history of cardiovascular events, nor with peripheral arterial disease. In contrast, positive associations were found for D-Dimer. Mean D-Dimer level was 40 microg/l (95% CI 35, 44) in control subjects; 53 microg/l (47, 61) in those with a history of myocardial infarction and 51 microg/l (45, 58) in those with a history of stroke and or transient ischemic attack. D-Dimer increased gradually with increasing severity of peripheral atherosclerosis; a decrease in ankle/arm systolic blood pressure ratio of 0.1 was associated with an increase in D-Dimer of 3.9 microg/l (p<0.01). This was more pronounced in subjects with higher F1+2, TAT and PAP concentration. In conclusion, the markers of onset of coagulation F1+2, TAT and PAP are not associated with the presence of arterial disease, but increased levels of these markers are necessary for the positive association between D-Dimer and arterial disease.

Authors+Show Affiliations

Julius Center for Patient Oriented Research, University Medical Center, Utrecht, The Netherlands. j.g.vanderbom@jc.azu.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11246539

Citation

van der Bom, J G., et al. "Activation Products of the Haemostatic System in Coronary, Cerebrovascular and Peripheral Arterial Disease." Thrombosis and Haemostasis, vol. 85, no. 2, 2001, pp. 234-9.
van der Bom JG, Bots ML, Haverkate F, et al. Activation products of the haemostatic system in coronary, cerebrovascular and peripheral arterial disease. Thromb Haemost. 2001;85(2):234-9.
van der Bom, J. G., Bots, M. L., Haverkate, F., Meijer, P., Hofman, A., Kluft, C., & Grobbee, D. E. (2001). Activation products of the haemostatic system in coronary, cerebrovascular and peripheral arterial disease. Thrombosis and Haemostasis, 85(2), 234-9.
van der Bom JG, et al. Activation Products of the Haemostatic System in Coronary, Cerebrovascular and Peripheral Arterial Disease. Thromb Haemost. 2001;85(2):234-9. PubMed PMID: 11246539.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Activation products of the haemostatic system in coronary, cerebrovascular and peripheral arterial disease. AU - van der Bom,J G, AU - Bots,M L, AU - Haverkate,F, AU - Meijer,P, AU - Hofman,A, AU - Kluft,C, AU - Grobbee,D E, PY - 2001/3/15/pubmed PY - 2001/6/29/medline PY - 2001/3/15/entrez SP - 234 EP - 9 JF - Thrombosis and haemostasis JO - Thromb Haemost VL - 85 IS - 2 N2 - To determine the presence of a 'hypercoagulable state' as assessed by indices of thrombin and plasmin generation and of the amount of fibrin that is lysed, in patients with stable coronary, cerebral and peripheral arterial disease a population-based cross-sectional study was performed. From a population-based cohort comprising 7983 men and women aged 55 years and over, we randomly selected 127 subjects with a history of myocardial infarction, 124 with a history of stroke and/or transient ischemic attack, 131 patients with peripheral arterial disease and 263 control subjects in the same age group without arterial disease. Subjects using anticoagulant drugs were not selected. F1+2, TAT, and PAP were not associated with a history of cardiovascular events, nor with peripheral arterial disease. In contrast, positive associations were found for D-Dimer. Mean D-Dimer level was 40 microg/l (95% CI 35, 44) in control subjects; 53 microg/l (47, 61) in those with a history of myocardial infarction and 51 microg/l (45, 58) in those with a history of stroke and or transient ischemic attack. D-Dimer increased gradually with increasing severity of peripheral atherosclerosis; a decrease in ankle/arm systolic blood pressure ratio of 0.1 was associated with an increase in D-Dimer of 3.9 microg/l (p<0.01). This was more pronounced in subjects with higher F1+2, TAT and PAP concentration. In conclusion, the markers of onset of coagulation F1+2, TAT and PAP are not associated with the presence of arterial disease, but increased levels of these markers are necessary for the positive association between D-Dimer and arterial disease. SN - 0340-6245 UR - https://www.unboundmedicine.com/medline/citation/11246539/Activation_products_of_the_haemostatic_system_in_coronary_cerebrovascular_and_peripheral_arterial_disease_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=11246539.ui DB - PRIME DP - Unbound Medicine ER -