Tags

Type your tag names separated by a space and hit enter

Anti-alpha-fodrin autoantibody is an early diagnostic marker for childhood primary Sjögren's syndrome.
J Rheumatol. 2001 Feb; 28(2):363-5.JR

Abstract

OBJECTIVE

alpha-fodrin is a recently identified autoantigen associated with adult primary Sjögren's syndrome (SS). We tested whether anti-alpha-fodrin antibody could also be used as a diagnostic marker for childhood SS.

METHODS

We performed immunoblot analysis of sera from 7 patients with childhood primary SS using glutathione-S-transferase alpha-fodrin fusion protein as an antigen.

RESULTS

Anti-alpha-fodrin antibody was detected in sera from all 7 patients with childhood primary SS, 2 of 4 with secondary SS, and one of 7 with systemic lupus erythematosus, but in no other healthy controls.

CONCLUSION

The anti-alpha-fodrin autoantibody was detected before anti-SSA or SSB antibody became positive; thus anti-alpha-fodrin antibody could be a useful marker for the early diagnosis of SS.

Authors+Show Affiliations

Department of Pediatrics, Hokkaido University School of Medicine, Pediatric Clinics, Sapporo Kohnan Hospital, Sapporo, Japan. ichikoba@med.hokudai.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11246678

Citation

Kobayashi, I, et al. "Anti-alpha-fodrin Autoantibody Is an Early Diagnostic Marker for Childhood Primary Sjögren's Syndrome." The Journal of Rheumatology, vol. 28, no. 2, 2001, pp. 363-5.
Kobayashi I, Kawamura N, Okano M, et al. Anti-alpha-fodrin autoantibody is an early diagnostic marker for childhood primary Sjögren's syndrome. J Rheumatol. 2001;28(2):363-5.
Kobayashi, I., Kawamura, N., Okano, M., Shikano, T., Mizumoto, M., Hayashi, Y., & Kobayashi, K. (2001). Anti-alpha-fodrin autoantibody is an early diagnostic marker for childhood primary Sjögren's syndrome. The Journal of Rheumatology, 28(2), 363-5.
Kobayashi I, et al. Anti-alpha-fodrin Autoantibody Is an Early Diagnostic Marker for Childhood Primary Sjögren's Syndrome. J Rheumatol. 2001;28(2):363-5. PubMed PMID: 11246678.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-alpha-fodrin autoantibody is an early diagnostic marker for childhood primary Sjögren's syndrome. AU - Kobayashi,I, AU - Kawamura,N, AU - Okano,M, AU - Shikano,T, AU - Mizumoto,M, AU - Hayashi,Y, AU - Kobayashi,K, PY - 2001/3/15/pubmed PY - 2001/6/15/medline PY - 2001/3/15/entrez SP - 363 EP - 5 JF - The Journal of rheumatology JO - J Rheumatol VL - 28 IS - 2 N2 - OBJECTIVE: alpha-fodrin is a recently identified autoantigen associated with adult primary Sjögren's syndrome (SS). We tested whether anti-alpha-fodrin antibody could also be used as a diagnostic marker for childhood SS. METHODS: We performed immunoblot analysis of sera from 7 patients with childhood primary SS using glutathione-S-transferase alpha-fodrin fusion protein as an antigen. RESULTS: Anti-alpha-fodrin antibody was detected in sera from all 7 patients with childhood primary SS, 2 of 4 with secondary SS, and one of 7 with systemic lupus erythematosus, but in no other healthy controls. CONCLUSION: The anti-alpha-fodrin autoantibody was detected before anti-SSA or SSB antibody became positive; thus anti-alpha-fodrin antibody could be a useful marker for the early diagnosis of SS. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/11246678/Anti_alpha_fodrin_autoantibody_is_an_early_diagnostic_marker_for_childhood_primary_Sjögren's_syndrome_ L2 - http://www.jrheum.org/cgi/pmidlookup?view=long&pmid=11246678 DB - PRIME DP - Unbound Medicine ER -