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Fat cell function and fibrinolysis.
Horm Metab Res 2000 Nov-Dec; 32(11-12):504-8HM

Abstract

Plasminogen activator inhibitor-1 (PAI-1) is a specific inhibitor of plasminogen activators and may be the principal regulator of plasminogen activation in vivo. PAI-1 levels are elevated in insulin-resistant subjects and are associated with an increased risk of atherothrombosis. After adjustment for metabolic parameters, increased PAI-1 levels were no longer considered as a cardiovascular risk factor. The mechanisms underlying the strong association between PAI-1 levels and the metabolic disturbances found in insulin resistance are still not understood. Several studies have suggested that visceral adipose tissue may be a major source of PAl-1. Accordingly, adipose tissue PAI-1 production particularly that from visceral fat, was found to be elevated in obese human subjects. Within human adipose tissue, stromal cells appear to be the main cells involved in PAI-1 synthesis. This review discusses the potential mechanisms linking adipose tissue to plasma PAI-1 levels such as the intervention of cytokines (TNFalpha and TGFbeta), free fatty acids and hormones (insulin and glucocorticoids). Moreover alteration of adipose tissue cellular composition induced by the modulation of PAI-1 expression opens a novel field of interest.

Authors+Show Affiliations

Laboratory of Hematology, Faculty of Medicine, CHU Timone, Marseille, France.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

11246816

Citation

Alessi, M C., et al. "Fat Cell Function and Fibrinolysis." Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, vol. 32, no. 11-12, 2000, pp. 504-8.
Alessi MC, Morange P, Juhan-Vague I. Fat cell function and fibrinolysis. Horm Metab Res. 2000;32(11-12):504-8.
Alessi, M. C., Morange, P., & Juhan-Vague, I. (2000). Fat cell function and fibrinolysis. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, 32(11-12), pp. 504-8.
Alessi MC, Morange P, Juhan-Vague I. Fat Cell Function and Fibrinolysis. Horm Metab Res. 2000;32(11-12):504-8. PubMed PMID: 11246816.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fat cell function and fibrinolysis. AU - Alessi,M C, AU - Morange,P, AU - Juhan-Vague,I, PY - 2001/3/15/pubmed PY - 2001/6/2/medline PY - 2001/3/15/entrez SP - 504 EP - 8 JF - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme JO - Horm. Metab. Res. VL - 32 IS - 11-12 N2 - Plasminogen activator inhibitor-1 (PAI-1) is a specific inhibitor of plasminogen activators and may be the principal regulator of plasminogen activation in vivo. PAI-1 levels are elevated in insulin-resistant subjects and are associated with an increased risk of atherothrombosis. After adjustment for metabolic parameters, increased PAI-1 levels were no longer considered as a cardiovascular risk factor. The mechanisms underlying the strong association between PAI-1 levels and the metabolic disturbances found in insulin resistance are still not understood. Several studies have suggested that visceral adipose tissue may be a major source of PAl-1. Accordingly, adipose tissue PAI-1 production particularly that from visceral fat, was found to be elevated in obese human subjects. Within human adipose tissue, stromal cells appear to be the main cells involved in PAI-1 synthesis. This review discusses the potential mechanisms linking adipose tissue to plasma PAI-1 levels such as the intervention of cytokines (TNFalpha and TGFbeta), free fatty acids and hormones (insulin and glucocorticoids). Moreover alteration of adipose tissue cellular composition induced by the modulation of PAI-1 expression opens a novel field of interest. SN - 0018-5043 UR - https://www.unboundmedicine.com/medline/citation/11246816/Fat_cell_function_and_fibrinolysis_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2007-978677 DB - PRIME DP - Unbound Medicine ER -