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A prospective cohort study of physical activity and body size in relation to prostate cancer risk (United States).
Cancer Causes Control 2001; 12(2):187-93CC

Abstract

OBJECTIVES

To examine the associations of physical activity and body size with risk of prostate cancer.

METHODS

At baseline in 1988, 8922 men (mean age 67 years) completed a health questionnaire which included information on physical activity, body weight, and waist girth. In a subgroup (74% of men), physical activity data also had been provided in 1962 or 1966 and again in 1977. Additionally, body weight measured at age 18 was available for 92% of men. During follow-up from 1988 through 1993, 439 men developed prostate cancer.

RESULTS

In multivariate analyses that accounted for potential confounders, the RRs (95% CI) for < 4200, 4200-8399, 8400-12,599, and > or = 12,600 kJ/week of physical activity at baseline were 1.00 (referent), 1.13 (0.84-1.52), 0.96 (0.68-1.35), and 1.04 (0.79-1.38), respectively. For body mass indexes (BMI) of < 22.5, 22.5-24.9, 25.0-27.4, and > or = 27.5 kg/m2 at baseline, corresponding results were 1.00 (referent), 1.27 (0.94-1.71), 1.26 (0.92-1.72), and 1.02 (0.68-1.53), respectively. For waist girths of < or = 86.4, 86.5-91.4, 91.5-96.5, and > 96.5 cm, they were 1.00 (referent), 1.30 (0.96-1.76), 1.31 (0.96-1.80), and 1.19 (0.85-1.65), respectively. Combining physical activity measures from the past, or examining vigorous activities only, did not yield any significant associations. BMI at age 18 also was not related to risk.

CONCLUSION

These findings do not support a role of physical activity or body weight in prostate cancer etiology.

Authors+Show Affiliations

Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA. i-min.lee@channing.harvard.edu

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11246848

Citation

Lee, I M., et al. "A Prospective Cohort Study of Physical Activity and Body Size in Relation to Prostate Cancer Risk (United States)." Cancer Causes & Control : CCC, vol. 12, no. 2, 2001, pp. 187-93.
Lee IM, Sesso HD, Paffenbarger RS. A prospective cohort study of physical activity and body size in relation to prostate cancer risk (United States). Cancer Causes Control. 2001;12(2):187-93.
Lee, I. M., Sesso, H. D., & Paffenbarger, R. S. (2001). A prospective cohort study of physical activity and body size in relation to prostate cancer risk (United States). Cancer Causes & Control : CCC, 12(2), pp. 187-93.
Lee IM, Sesso HD, Paffenbarger RS. A Prospective Cohort Study of Physical Activity and Body Size in Relation to Prostate Cancer Risk (United States). Cancer Causes Control. 2001;12(2):187-93. PubMed PMID: 11246848.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A prospective cohort study of physical activity and body size in relation to prostate cancer risk (United States). AU - Lee,I M, AU - Sesso,H D, AU - Paffenbarger,R S,Jr PY - 2001/3/15/pubmed PY - 2001/5/26/medline PY - 2001/3/15/entrez SP - 187 EP - 93 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 12 IS - 2 N2 - OBJECTIVES: To examine the associations of physical activity and body size with risk of prostate cancer. METHODS: At baseline in 1988, 8922 men (mean age 67 years) completed a health questionnaire which included information on physical activity, body weight, and waist girth. In a subgroup (74% of men), physical activity data also had been provided in 1962 or 1966 and again in 1977. Additionally, body weight measured at age 18 was available for 92% of men. During follow-up from 1988 through 1993, 439 men developed prostate cancer. RESULTS: In multivariate analyses that accounted for potential confounders, the RRs (95% CI) for < 4200, 4200-8399, 8400-12,599, and > or = 12,600 kJ/week of physical activity at baseline were 1.00 (referent), 1.13 (0.84-1.52), 0.96 (0.68-1.35), and 1.04 (0.79-1.38), respectively. For body mass indexes (BMI) of < 22.5, 22.5-24.9, 25.0-27.4, and > or = 27.5 kg/m2 at baseline, corresponding results were 1.00 (referent), 1.27 (0.94-1.71), 1.26 (0.92-1.72), and 1.02 (0.68-1.53), respectively. For waist girths of < or = 86.4, 86.5-91.4, 91.5-96.5, and > 96.5 cm, they were 1.00 (referent), 1.30 (0.96-1.76), 1.31 (0.96-1.80), and 1.19 (0.85-1.65), respectively. Combining physical activity measures from the past, or examining vigorous activities only, did not yield any significant associations. BMI at age 18 also was not related to risk. CONCLUSION: These findings do not support a role of physical activity or body weight in prostate cancer etiology. SN - 0957-5243 UR - https://www.unboundmedicine.com/medline/citation/11246848/A_prospective_cohort_study_of_physical_activity_and_body_size_in_relation_to_prostate_cancer_risk__United_States__ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=11246848.ui DB - PRIME DP - Unbound Medicine ER -