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Lobular carcinoma in situ on core biopsy-what is the clinical significance?
Clin Radiol. 2001 Mar; 56(3):216-20.CR

Abstract

AIM

To retrospectively review the surgical histological findings in all cases where lobular carcinoma in situ(LCIS) was identified on percutaneous core biopsy (CB) performed as part of the Cambridge and Huntingdon breast screening programme.

MATERIALS AND METHODS

We retrospectively reviewed all the core biopsies performed in our department for screen detected abnormalities over a 5-year period between 1 April 1994 and 31 March 1999. All patients where LCIS was identified on CB were reviewed. As the significance of LCIS on CB was unclear all went on to surgical excision. We reviewed the clinical and imaging findings, biopsy technique and subsequent surgical histology of each patient.

RESULTS

During the study period 60 769 women were invited for screening, of whom 47 975 attended (attendance rate = 79%). Of these, 2330 (4.9%) were recalled for assessment and 749 (1.6%) underwent CB. A malignant diagnosis was obtained in 311 (42%), 211 invasive and 100 in situ lesions. LCIS was identified on CB in 13 (2%). LCIS was the only lesion identified in seven cases. All seven cases subsequently underwent surgical excision. Surgical histology revealed a single case of LCIS and invasive lobular carcinoma. There were two cases of LCIS and DCIS one with a probable focus of invasive ductal carcinoma. In one case LCIS was identified in association with a radial scar. In three of the seven cases LCIS was the only abnormality on both CB and surgical biopsy.

CONCLUSION

Our series shows that isolated LCIS on CB following mammographic screening is an infrequent finding, and it may be associated with either an invasive cancer or DCIS. It is therefore advisable that when LCIS is identified on CB, surgical excision of the mammographic abnormality should be performed. Decisions on management should be undertaken in a multidisciplinary setting taking into account clinical and imaging findings.

Authors+Show Affiliations

Department of Radiology, Addenbrooke's Hospital, Cambridge, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11247699

Citation

O'Driscoll, D, et al. "Lobular Carcinoma in Situ On Core Biopsy-what Is the Clinical Significance?" Clinical Radiology, vol. 56, no. 3, 2001, pp. 216-20.
O'Driscoll D, Britton P, Bobrow L, et al. Lobular carcinoma in situ on core biopsy-what is the clinical significance? Clin Radiol. 2001;56(3):216-20.
O'Driscoll, D., Britton, P., Bobrow, L., Wishart, G. C., Sinnatamby, R., & Warren, R. (2001). Lobular carcinoma in situ on core biopsy-what is the clinical significance? Clinical Radiology, 56(3), 216-20.
O'Driscoll D, et al. Lobular Carcinoma in Situ On Core Biopsy-what Is the Clinical Significance. Clin Radiol. 2001;56(3):216-20. PubMed PMID: 11247699.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lobular carcinoma in situ on core biopsy-what is the clinical significance? AU - O'Driscoll,D, AU - Britton,P, AU - Bobrow,L, AU - Wishart,G C, AU - Sinnatamby,R, AU - Warren,R, PY - 2001/3/15/pubmed PY - 2001/4/17/medline PY - 2001/3/15/entrez SP - 216 EP - 20 JF - Clinical radiology JO - Clin Radiol VL - 56 IS - 3 N2 - AIM: To retrospectively review the surgical histological findings in all cases where lobular carcinoma in situ(LCIS) was identified on percutaneous core biopsy (CB) performed as part of the Cambridge and Huntingdon breast screening programme. MATERIALS AND METHODS: We retrospectively reviewed all the core biopsies performed in our department for screen detected abnormalities over a 5-year period between 1 April 1994 and 31 March 1999. All patients where LCIS was identified on CB were reviewed. As the significance of LCIS on CB was unclear all went on to surgical excision. We reviewed the clinical and imaging findings, biopsy technique and subsequent surgical histology of each patient. RESULTS: During the study period 60 769 women were invited for screening, of whom 47 975 attended (attendance rate = 79%). Of these, 2330 (4.9%) were recalled for assessment and 749 (1.6%) underwent CB. A malignant diagnosis was obtained in 311 (42%), 211 invasive and 100 in situ lesions. LCIS was identified on CB in 13 (2%). LCIS was the only lesion identified in seven cases. All seven cases subsequently underwent surgical excision. Surgical histology revealed a single case of LCIS and invasive lobular carcinoma. There were two cases of LCIS and DCIS one with a probable focus of invasive ductal carcinoma. In one case LCIS was identified in association with a radial scar. In three of the seven cases LCIS was the only abnormality on both CB and surgical biopsy. CONCLUSION: Our series shows that isolated LCIS on CB following mammographic screening is an infrequent finding, and it may be associated with either an invasive cancer or DCIS. It is therefore advisable that when LCIS is identified on CB, surgical excision of the mammographic abnormality should be performed. Decisions on management should be undertaken in a multidisciplinary setting taking into account clinical and imaging findings. SN - 0009-9260 UR - https://www.unboundmedicine.com/medline/citation/11247699/Lobular_carcinoma_in_situ_on_core_biopsy_what_is_the_clinical_significance L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-9260(00)90615-9 DB - PRIME DP - Unbound Medicine ER -