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CNTF genotype is associated with muscular strength and quality in humans across the adult age span.
J Appl Physiol (1985). 2001 Apr; 90(4):1205-10.JA

Abstract

The relationship between ciliary neurotrophic factor (CNTF) genotype and muscle strength was examined in 494 healthy men and women across the entire adult age span (20-90 yr). Concentric (Con) and eccentric (Ecc) peak torque were assessed using a Kin-Com isokinetic dynamometer for the knee extensors (KE) and knee flexors (KF) at slow (0.52 rad/s) and faster (3.14 rad/s) velocities. The results were covaried for age, gender, and body mass or fat-free mass (FFM). Individuals heterozygous for the CNTF null (A allele) mutation (G/A) exhibited significantly higher Con peak torque of the KE and KF at 3.14 rad/s than G/G homozygotes when age, gender, and body mass were covaried (P < 0.05). When the dominant leg FFM (estimated muscle mass) was used in place of body mass as a covariate, Con peak torque of the KE at 3.14 rad/s was also significantly greater in the G/A individuals (P < 0.05). In addition, muscle quality of the KE (peak torque at 3.14 rad x s(-1) x leg muscle mass(-1)) was significantly greater in the G/A heterozygotes (P < 0.05). Similar results were seen in a subanalysis of subjects 60 yr and older, as well as in Caucasian subjects. In contrast, A/A homozygotes demonstrated significantly lower Ecc peak torque at 0.52 rad/s for both KE and KF compared with G/G and G/A groups (P < 0.05). No significant relationships were observed at 0.52 rad/s between genotype and Con peak torque. These data indicate that individuals exhibiting the G/A genotype possess significantly greater muscular strength and muscle quality at relatively fast contraction speeds than do G/G individuals. Because of high positive correlations between fast-velocity peak torque and muscular power, these findings suggest that further investigations should address the relationship between CNTF genotype and muscular power.

Authors+Show Affiliations

Department of Kinesiology, College of Health and Human Performance, University of Maryland, College Park 20742, Maryland, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11247915

Citation

Roth, S M., et al. "CNTF Genotype Is Associated With Muscular Strength and Quality in Humans Across the Adult Age Span." Journal of Applied Physiology (Bethesda, Md. : 1985), vol. 90, no. 4, 2001, pp. 1205-10.
Roth SM, Schrager MA, Ferrell RE, et al. CNTF genotype is associated with muscular strength and quality in humans across the adult age span. J Appl Physiol (1985). 2001;90(4):1205-10.
Roth, S. M., Schrager, M. A., Ferrell, R. E., Riechman, S. E., Metter, E. J., Lynch, N. A., Lindle, R. S., & Hurley, B. F. (2001). CNTF genotype is associated with muscular strength and quality in humans across the adult age span. Journal of Applied Physiology (Bethesda, Md. : 1985), 90(4), 1205-10.
Roth SM, et al. CNTF Genotype Is Associated With Muscular Strength and Quality in Humans Across the Adult Age Span. J Appl Physiol (1985). 2001;90(4):1205-10. PubMed PMID: 11247915.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CNTF genotype is associated with muscular strength and quality in humans across the adult age span. AU - Roth,S M, AU - Schrager,M A, AU - Ferrell,R E, AU - Riechman,S E, AU - Metter,E J, AU - Lynch,N A, AU - Lindle,R S, AU - Hurley,B F, PY - 2001/3/15/pubmed PY - 2001/6/2/medline PY - 2001/3/15/entrez SP - 1205 EP - 10 JF - Journal of applied physiology (Bethesda, Md. : 1985) JO - J Appl Physiol (1985) VL - 90 IS - 4 N2 - The relationship between ciliary neurotrophic factor (CNTF) genotype and muscle strength was examined in 494 healthy men and women across the entire adult age span (20-90 yr). Concentric (Con) and eccentric (Ecc) peak torque were assessed using a Kin-Com isokinetic dynamometer for the knee extensors (KE) and knee flexors (KF) at slow (0.52 rad/s) and faster (3.14 rad/s) velocities. The results were covaried for age, gender, and body mass or fat-free mass (FFM). Individuals heterozygous for the CNTF null (A allele) mutation (G/A) exhibited significantly higher Con peak torque of the KE and KF at 3.14 rad/s than G/G homozygotes when age, gender, and body mass were covaried (P < 0.05). When the dominant leg FFM (estimated muscle mass) was used in place of body mass as a covariate, Con peak torque of the KE at 3.14 rad/s was also significantly greater in the G/A individuals (P < 0.05). In addition, muscle quality of the KE (peak torque at 3.14 rad x s(-1) x leg muscle mass(-1)) was significantly greater in the G/A heterozygotes (P < 0.05). Similar results were seen in a subanalysis of subjects 60 yr and older, as well as in Caucasian subjects. In contrast, A/A homozygotes demonstrated significantly lower Ecc peak torque at 0.52 rad/s for both KE and KF compared with G/G and G/A groups (P < 0.05). No significant relationships were observed at 0.52 rad/s between genotype and Con peak torque. These data indicate that individuals exhibiting the G/A genotype possess significantly greater muscular strength and muscle quality at relatively fast contraction speeds than do G/G individuals. Because of high positive correlations between fast-velocity peak torque and muscular power, these findings suggest that further investigations should address the relationship between CNTF genotype and muscular power. SN - 8750-7587 UR - https://www.unboundmedicine.com/medline/citation/11247915/CNTF_genotype_is_associated_with_muscular_strength_and_quality_in_humans_across_the_adult_age_span_ L2 - https://journals.physiology.org/doi/10.1152/jappl.2001.90.4.1205?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -