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Effect of intracochlear aminooxyacetic acid on cochlear potentials and endolymph composition.
Ann Otol Rhinol Laryngol. 1975 Mar-Apr; 84(2 PART 1):192-7.AO

Abstract

Summary--Aminooxyacetic acid (AOAA; 1 MM) when perfused through the scala tympani of guinea pigs produced a biphasic reduction in the endocochlear potential, together with a shift in the input-output functions of the cochlear microphonics and the compound action potential of the cochlear nerve. Since the ionic (Na+, K+) content of the scala media was not alerted, it appears that such changes did not underlie the reduction recorded in the endocochlear potential. The negative direct current potential recorded in the organ of Corti did not appear to be affected by the drug. Attempts to antagonize the effects of AOAA with pyridoxine failed.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

1124907

Citation

Robbin, R P., and M I. Gondra. "Effect of Intracochlear Aminooxyacetic Acid On Cochlear Potentials and Endolymph Composition." The Annals of Otology, Rhinology, and Laryngology, vol. 84, no. 2 PART 1, 1975, pp. 192-7.
Robbin RP, Gondra MI. Effect of intracochlear aminooxyacetic acid on cochlear potentials and endolymph composition. Ann Otol Rhinol Laryngol. 1975;84(2 PART 1):192-7.
Robbin, R. P., & Gondra, M. I. (1975). Effect of intracochlear aminooxyacetic acid on cochlear potentials and endolymph composition. The Annals of Otology, Rhinology, and Laryngology, 84(2 PART 1), 192-7.
Robbin RP, Gondra MI. Effect of Intracochlear Aminooxyacetic Acid On Cochlear Potentials and Endolymph Composition. Ann Otol Rhinol Laryngol. 1975 Mar-Apr;84(2 PART 1):192-7. PubMed PMID: 1124907.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of intracochlear aminooxyacetic acid on cochlear potentials and endolymph composition. AU - Robbin,R P, AU - Gondra,M I, PY - 1975/3/1/pubmed PY - 1975/3/1/medline PY - 1975/3/1/entrez SP - 192 EP - 7 JF - The Annals of otology, rhinology, and laryngology JO - Ann Otol Rhinol Laryngol VL - 84 IS - 2 PART 1 N2 - Summary--Aminooxyacetic acid (AOAA; 1 MM) when perfused through the scala tympani of guinea pigs produced a biphasic reduction in the endocochlear potential, together with a shift in the input-output functions of the cochlear microphonics and the compound action potential of the cochlear nerve. Since the ionic (Na+, K+) content of the scala media was not alerted, it appears that such changes did not underlie the reduction recorded in the endocochlear potential. The negative direct current potential recorded in the organ of Corti did not appear to be affected by the drug. Attempts to antagonize the effects of AOAA with pyridoxine failed. SN - 0003-4894 UR - https://www.unboundmedicine.com/medline/citation/1124907/Effect_of_intracochlear_aminooxyacetic_acid_on_cochlear_potentials_and_endolymph_composition_ L2 - https://journals.sagepub.com/doi/10.1177/000348947508400209?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -