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Midodrine: a selective alpha-adrenergic agonist for orthostatic hypotension and dialysis hypotension.
Expert Opin Pharmacother. 2000 May; 1(4):835-40.EO

Abstract

Midodrine is an oral agent which acts as a selective peripherally-acting alpha-receptor agonist. Midodrine is a prodrug that is almost completely absorbed after oral administration and converted into its active drug de-glymidodrine in the systematic circulation, with a bioavailability of 93%. It has been used successfully in the treatment of neurogenic orthostatic hypotension and more recently, in the treatment of dialysis hypotension. It acts through vasoconstriction of the arterioles and the venous capacitance vessels, thereby increasing peripheral vascular resistance and augmenting venous return, respectively. It is a unique agent in the armamentarium against orthostatic hypotension since it has minimal cardiac and CNS effects. This article will review the literature on midodrine for conditions of autonomic dysfunction, with focus on recent studies on its use in haemodialysis patients.

Authors+Show Affiliations

Section of Nephrology, Department of Medicine, Yale University School of Medicine, 333 Cedar Street LMP 2071, New Haven, CT 06520-8029, USA. dinna.cruz@yale.edu

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

11249519

Citation

Cruz, D N.. "Midodrine: a Selective Alpha-adrenergic Agonist for Orthostatic Hypotension and Dialysis Hypotension." Expert Opinion On Pharmacotherapy, vol. 1, no. 4, 2000, pp. 835-40.
Cruz DN. Midodrine: a selective alpha-adrenergic agonist for orthostatic hypotension and dialysis hypotension. Expert Opin Pharmacother. 2000;1(4):835-40.
Cruz, D. N. (2000). Midodrine: a selective alpha-adrenergic agonist for orthostatic hypotension and dialysis hypotension. Expert Opinion On Pharmacotherapy, 1(4), 835-40.
Cruz DN. Midodrine: a Selective Alpha-adrenergic Agonist for Orthostatic Hypotension and Dialysis Hypotension. Expert Opin Pharmacother. 2000;1(4):835-40. PubMed PMID: 11249519.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Midodrine: a selective alpha-adrenergic agonist for orthostatic hypotension and dialysis hypotension. A1 - Cruz,D N, PY - 2001/3/16/pubmed PY - 2001/4/6/medline PY - 2001/3/16/entrez SP - 835 EP - 40 JF - Expert opinion on pharmacotherapy JO - Expert Opin Pharmacother VL - 1 IS - 4 N2 - Midodrine is an oral agent which acts as a selective peripherally-acting alpha-receptor agonist. Midodrine is a prodrug that is almost completely absorbed after oral administration and converted into its active drug de-glymidodrine in the systematic circulation, with a bioavailability of 93%. It has been used successfully in the treatment of neurogenic orthostatic hypotension and more recently, in the treatment of dialysis hypotension. It acts through vasoconstriction of the arterioles and the venous capacitance vessels, thereby increasing peripheral vascular resistance and augmenting venous return, respectively. It is a unique agent in the armamentarium against orthostatic hypotension since it has minimal cardiac and CNS effects. This article will review the literature on midodrine for conditions of autonomic dysfunction, with focus on recent studies on its use in haemodialysis patients. SN - 1465-6566 UR - https://www.unboundmedicine.com/medline/citation/11249519/Midodrine:_a_selective_alpha_adrenergic_agonist_for_orthostatic_hypotension_and_dialysis_hypotension_ L2 - https://www.tandfonline.com/doi/full/10.1517/14656566.1.4.835 DB - PRIME DP - Unbound Medicine ER -