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Dopaminergic effects of histamine administration in the nucleus accumbens and the impact of H1-receptor blockade.
Neuropharmacology. 2001 Mar; 40(4):624-33.N

Abstract

The mesolimbic dopamine system is thought to play a critical role in reward-related processes. A number of studies have shown that lesion or inhibition of histaminergic neurons acting through H1 receptors can potentiate the effects of drug-induced reward (e.g., psychostimulants and opioids) and can enhance the reinforcing effects of electrical stimulation of the brain. Since dopamine transmission in the nucleus accumbens is thought to provide a crucial link in these histaminergic actions, we examined the effects of local histamine application (0.1, 1.0 and 10.0 micromol/l) on dopamine and its metabolites in the nucleus accumbens of anesthetized rats by means of unilateral reverse dialysis. To study the influence of H1 receptors, we also applied the H1-receptor antagonist pyrilamine (10.0 and 20.0 mg/kg, intraperitoneally) 20 min before histamine administration (1 mmol/l). Finally, pyrilamine (0.1, 1.0 and 10.0 micromol/l) was locally administered into the nucleus accumbens. The data show that histamine can enhance extracellular dopamine levels in the nucleus accumbens in a dose-dependent way. This increase was partially antagonized by prior peripheral administration of 10 mg/kg, and was completely blocked by 20 mg/kg, of pyrilamine. Finally, intra-accumbens administration of pyrilamine locally decreased dopamine and increased dihydroxyphenylacetic acid and homovanillic acid levels. These data are discussed with respect to the possible interactions between dopaminergic and histaminergic mechanisms in the mesolimbic system and their relation to mechanisms of reinforcement.

Authors+Show Affiliations

Institute of Physiology and Neurophysiology Research Group of Hungarian Academy of Sciences, Pecs University Medical School, Pecs, Hungary.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11249972

Citation

Galosi, R, et al. "Dopaminergic Effects of Histamine Administration in the Nucleus Accumbens and the Impact of H1-receptor Blockade." Neuropharmacology, vol. 40, no. 4, 2001, pp. 624-33.
Galosi R, Lenard L, Knoche A, et al. Dopaminergic effects of histamine administration in the nucleus accumbens and the impact of H1-receptor blockade. Neuropharmacology. 2001;40(4):624-33.
Galosi, R., Lenard, L., Knoche, A., Haas, H., Huston, J. P., & Schwarting, R. K. (2001). Dopaminergic effects of histamine administration in the nucleus accumbens and the impact of H1-receptor blockade. Neuropharmacology, 40(4), 624-33.
Galosi R, et al. Dopaminergic Effects of Histamine Administration in the Nucleus Accumbens and the Impact of H1-receptor Blockade. Neuropharmacology. 2001;40(4):624-33. PubMed PMID: 11249972.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dopaminergic effects of histamine administration in the nucleus accumbens and the impact of H1-receptor blockade. AU - Galosi,R, AU - Lenard,L, AU - Knoche,A, AU - Haas,H, AU - Huston,J P, AU - Schwarting,R K, PY - 2001/3/16/pubmed PY - 2001/5/22/medline PY - 2001/3/16/entrez SP - 624 EP - 33 JF - Neuropharmacology JO - Neuropharmacology VL - 40 IS - 4 N2 - The mesolimbic dopamine system is thought to play a critical role in reward-related processes. A number of studies have shown that lesion or inhibition of histaminergic neurons acting through H1 receptors can potentiate the effects of drug-induced reward (e.g., psychostimulants and opioids) and can enhance the reinforcing effects of electrical stimulation of the brain. Since dopamine transmission in the nucleus accumbens is thought to provide a crucial link in these histaminergic actions, we examined the effects of local histamine application (0.1, 1.0 and 10.0 micromol/l) on dopamine and its metabolites in the nucleus accumbens of anesthetized rats by means of unilateral reverse dialysis. To study the influence of H1 receptors, we also applied the H1-receptor antagonist pyrilamine (10.0 and 20.0 mg/kg, intraperitoneally) 20 min before histamine administration (1 mmol/l). Finally, pyrilamine (0.1, 1.0 and 10.0 micromol/l) was locally administered into the nucleus accumbens. The data show that histamine can enhance extracellular dopamine levels in the nucleus accumbens in a dose-dependent way. This increase was partially antagonized by prior peripheral administration of 10 mg/kg, and was completely blocked by 20 mg/kg, of pyrilamine. Finally, intra-accumbens administration of pyrilamine locally decreased dopamine and increased dihydroxyphenylacetic acid and homovanillic acid levels. These data are discussed with respect to the possible interactions between dopaminergic and histaminergic mechanisms in the mesolimbic system and their relation to mechanisms of reinforcement. SN - 0028-3908 UR - https://www.unboundmedicine.com/medline/citation/11249972/Dopaminergic_effects_of_histamine_administration_in_the_nucleus_accumbens_and_the_impact_of_H1_receptor_blockade_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0028390800001817 DB - PRIME DP - Unbound Medicine ER -