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Plasma protein synthesis in patients with low-grade nephrotic proteinuria.
Am J Physiol Endocrinol Metab. 2001 Apr; 280(4):E591-7.AJ

Abstract

Overt nephrotic syndrome is characterized by albumin and fibrinogen hyperproduction and reduced very low density lipoprotein apolipoprotein B-100 (VLDL apoB-100) clearance. Whether similar changes also occur in low-grade proteinuria is not known. Thus we measured albumin, fibrinogen, and VLDL apoB-100 kinetics in six patients with modest proteinuria and normal creatinine clearance (P) and in ten control subjects (C) by leucine tracer infusion and precursor-product relationships. In P, plasma albumin concentration was decreased (P < 0.003), whereas concentrations of fibrinogen and VLDL apoB-100 were increased (P < 0.001). In P, albumin fractional secretion rate (FSR) was increased (P < 0.01), fibrinogen FSR was normal, and VLDL apoB-100 FSR was decreased (P < 0.03). As a result, in P, absolute secretion rates (ASR) of albumin and fibrinogen were increased (P < 0.03), whereas VLDL apoB-100 ASR was normal. Albumin FSR was inversely correlated to oncotic pressure in P but not in C. These findings suggest that low-grade nephrotic proteinuria is characterized by simultaneous multiple alterations in turnover rates of albumin, fibrinogen, and VLDL apoB-100. Their pathogenesis, however, appears to be multifactorial.

Authors+Show Affiliations

Departments of Metabolic Diseases and Internal Medicine, University of Padova, 35128 Padua, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11254466

Citation

Zanetti, M, et al. "Plasma Protein Synthesis in Patients With Low-grade Nephrotic Proteinuria." American Journal of Physiology. Endocrinology and Metabolism, vol. 280, no. 4, 2001, pp. E591-7.
Zanetti M, Barazzoni R, Garibotto G, et al. Plasma protein synthesis in patients with low-grade nephrotic proteinuria. Am J Physiol Endocrinol Metab. 2001;280(4):E591-7.
Zanetti, M., Barazzoni, R., Garibotto, G., Davanzo, G., Gabelli, C., Kiwanuka, E., Piccoli, A., Tosolini, M., & Tessari, P. (2001). Plasma protein synthesis in patients with low-grade nephrotic proteinuria. American Journal of Physiology. Endocrinology and Metabolism, 280(4), E591-7.
Zanetti M, et al. Plasma Protein Synthesis in Patients With Low-grade Nephrotic Proteinuria. Am J Physiol Endocrinol Metab. 2001;280(4):E591-7. PubMed PMID: 11254466.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma protein synthesis in patients with low-grade nephrotic proteinuria. AU - Zanetti,M, AU - Barazzoni,R, AU - Garibotto,G, AU - Davanzo,G, AU - Gabelli,C, AU - Kiwanuka,E, AU - Piccoli,A, AU - Tosolini,M, AU - Tessari,P, PY - 2001/3/20/pubmed PY - 2001/4/17/medline PY - 2001/3/20/entrez SP - E591 EP - 7 JF - American journal of physiology. Endocrinology and metabolism JO - Am. J. Physiol. Endocrinol. Metab. VL - 280 IS - 4 N2 - Overt nephrotic syndrome is characterized by albumin and fibrinogen hyperproduction and reduced very low density lipoprotein apolipoprotein B-100 (VLDL apoB-100) clearance. Whether similar changes also occur in low-grade proteinuria is not known. Thus we measured albumin, fibrinogen, and VLDL apoB-100 kinetics in six patients with modest proteinuria and normal creatinine clearance (P) and in ten control subjects (C) by leucine tracer infusion and precursor-product relationships. In P, plasma albumin concentration was decreased (P < 0.003), whereas concentrations of fibrinogen and VLDL apoB-100 were increased (P < 0.001). In P, albumin fractional secretion rate (FSR) was increased (P < 0.01), fibrinogen FSR was normal, and VLDL apoB-100 FSR was decreased (P < 0.03). As a result, in P, absolute secretion rates (ASR) of albumin and fibrinogen were increased (P < 0.03), whereas VLDL apoB-100 ASR was normal. Albumin FSR was inversely correlated to oncotic pressure in P but not in C. These findings suggest that low-grade nephrotic proteinuria is characterized by simultaneous multiple alterations in turnover rates of albumin, fibrinogen, and VLDL apoB-100. Their pathogenesis, however, appears to be multifactorial. SN - 0193-1849 UR - https://www.unboundmedicine.com/medline/citation/11254466/Plasma_protein_synthesis_in_patients_with_low_grade_nephrotic_proteinuria_ L2 - http://journals.physiology.org/doi/full/10.1152/ajpendo.2001.280.4.E591?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -