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Physical activity and risk of cognitive impairment and dementia in elderly persons.

Abstract

CONTEXT

Dementia is common, costly, and highly age related. Little attention has been paid to the identification of modifiable lifestyle habits for its prevention.

OBJECTIVE

To explore the association between physical activity and the risk of cognitive impairment and dementia.

DESIGN, SETTING, AND SUBJECTS

Data come from a community sample of 9008 randomly selected men and women 65 years or older, who were evaluated in the 1991-1992 Canadian Study of Health and Aging, a prospective cohort study of dementia. Of the 6434 eligible subjects who were cognitively normal at baseline, 4615 completed a 5-year follow-up. Screening and clinical evaluations were done at both waves of the study. In 1996-1997, 3894 remained without cognitive impairment, 436 were diagnosed as having cognitive impairment-no dementia, and 285 were diagnosed as having dementia.

MAIN OUTCOME MEASURE

Incident cognitive impairment and dementia by levels of physical activity at baseline.

RESULTS

Compared with no exercise, physical activity was associated with lower risks of cognitive impairment, Alzheimer disease, and dementia of any type. Significant trends for increased protection with greater physical activity were observed. High levels of physical activity were associated with reduced risks of cognitive impairment (age-, sex-, and education-adjusted odds ratio, 0.58; 95% confidence interval, 0.41-0.83), Alzheimer disease (odds ratio, 0.50; 95% confidence interval, 0.28-0.90), and dementia of any type (odds ratio, 0.63; 95% confidence interval, 0.40-0.98).

CONCLUSION

Regular physical activity could represent an important and potent protective factor for cognitive decline and dementia in elderly persons.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Laval University Geriatric Research Unit, Centre d'hébergement St-Augustin du Centre hospitalier affilié universitaire de Québec, 2135 Terrasse Cadieux, Beauport, Quebec, Canada G1C 1Z2.

    , , ,

    Source

    Archives of neurology 58:3 2001 Mar pg 498-504

    MeSH

    Aged
    Aged, 80 and over
    Canada
    Cognition Disorders
    Dementia
    Exercise
    Female
    Humans
    Life Style
    Male
    Prospective Studies
    Risk Factors

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    11255456

    Citation

    Laurin, D, et al. "Physical Activity and Risk of Cognitive Impairment and Dementia in Elderly Persons." Archives of Neurology, vol. 58, no. 3, 2001, pp. 498-504.
    Laurin D, Verreault R, Lindsay J, et al. Physical activity and risk of cognitive impairment and dementia in elderly persons. Arch Neurol. 2001;58(3):498-504.
    Laurin, D., Verreault, R., Lindsay, J., MacPherson, K., & Rockwood, K. (2001). Physical activity and risk of cognitive impairment and dementia in elderly persons. Archives of Neurology, 58(3), pp. 498-504.
    Laurin D, et al. Physical Activity and Risk of Cognitive Impairment and Dementia in Elderly Persons. Arch Neurol. 2001;58(3):498-504. PubMed PMID: 11255456.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Physical activity and risk of cognitive impairment and dementia in elderly persons. AU - Laurin,D, AU - Verreault,R, AU - Lindsay,J, AU - MacPherson,K, AU - Rockwood,K, PY - 2001/3/20/pubmed PY - 2001/4/6/medline PY - 2001/3/20/entrez SP - 498 EP - 504 JF - Archives of neurology JO - Arch. Neurol. VL - 58 IS - 3 N2 - CONTEXT: Dementia is common, costly, and highly age related. Little attention has been paid to the identification of modifiable lifestyle habits for its prevention. OBJECTIVE: To explore the association between physical activity and the risk of cognitive impairment and dementia. DESIGN, SETTING, AND SUBJECTS: Data come from a community sample of 9008 randomly selected men and women 65 years or older, who were evaluated in the 1991-1992 Canadian Study of Health and Aging, a prospective cohort study of dementia. Of the 6434 eligible subjects who were cognitively normal at baseline, 4615 completed a 5-year follow-up. Screening and clinical evaluations were done at both waves of the study. In 1996-1997, 3894 remained without cognitive impairment, 436 were diagnosed as having cognitive impairment-no dementia, and 285 were diagnosed as having dementia. MAIN OUTCOME MEASURE: Incident cognitive impairment and dementia by levels of physical activity at baseline. RESULTS: Compared with no exercise, physical activity was associated with lower risks of cognitive impairment, Alzheimer disease, and dementia of any type. Significant trends for increased protection with greater physical activity were observed. High levels of physical activity were associated with reduced risks of cognitive impairment (age-, sex-, and education-adjusted odds ratio, 0.58; 95% confidence interval, 0.41-0.83), Alzheimer disease (odds ratio, 0.50; 95% confidence interval, 0.28-0.90), and dementia of any type (odds ratio, 0.63; 95% confidence interval, 0.40-0.98). CONCLUSION: Regular physical activity could represent an important and potent protective factor for cognitive decline and dementia in elderly persons. SN - 0003-9942 UR - https://www.unboundmedicine.com/medline/citation/11255456/Physical_activity_and_risk_of_cognitive_impairment_and_dementia_in_elderly_persons_ L2 - https://jamanetwork.com/journals/jamaneurology/fullarticle/vol/58/pg/498 DB - PRIME DP - Unbound Medicine ER -