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[Intima-media thickness in healthy probands without risk factors for arteriosclerosis].
Dtsch Med Wochenschr. 2001 Feb 23; 126(8):193-7.DM

Abstract

BACKGROUND AND OBJECTIVE

Ultrasound examination of the intima-media thickness (IMT) is a well accepted, highly reproducible method for the evaluation of early atherosclerosis. However, for the exact interpretation of these measurements reference values for IMT should be determined. The present work provides for the first time normal values for IMT of the common carotid artery and the arteries of the lower limbs (common femoral, superficial and popliteal arteries) in a German population of healthy subjects without risk factors.

SUBJECTS AND METHODS

A total of 112 subjects (50 men, 62 women), aged 40 to 70, were examined, according to the following inclusion criteria: no diabetes or marked elevation of postprandial plasma glucose; non-smokers; no hypertension, obesity, dys/hyperlipidaemia or albuminuria; no history of coronary heart disease, stroke and peripheral arterial occlusion. IMT was measured and standardized by the method of Pignoli. Total cholesterol, triglycerides, HDL-cholesterol, HbA1c, plasma glucose (fasting and postprandial) and albuminuria were examined by routine methods.

RESULTS

The mean values of double measurements bilaterally in the distal part of the common carotid artery in men were 0.79 (0.73 ... 0.84) mm (40-54 years) and 0.87 (0.81 ... 0.93) mm (55-70 years). In women the values were: -0.70 (0.67 ... 0.75) mm and 0.82 (0.75 ... 0.90) mm, resp. In the group aged 40-54 years the men showed significantly higher IMT of all examined vessels in comparison to the women. In the group aged 55-70 years somewhat higher IMT of the common carotid artery and significantly higher IMT of the arteries of the lower extremity were observed in men. In multivariate analysis age was found to be a significant determinant of IMT of all examined vessels.

CONCLUSION

Intima-media thickening of the common carotid artery in men aged 40-70 years is to be accepted if a single measurement of IMT exceeds > or = 1 mm. For women, aged 40-54 years, IMT is defined as pathological if one IMT is above 0.85 mm, and for those aged 55-70 years if IMT exceeds 1 mm.

Authors+Show Affiliations

Zentrum für Klinische Studien, Forschungsbereich Endokrinologie und Stoffwechsel, Gesellschaft für Wissens- und Technologietransfer, Technischen Universität Dresden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

ger

PubMed ID

11256022

Citation

Temelkova-Kurktschiev, T, et al. "[Intima-media Thickness in Healthy Probands Without Risk Factors for Arteriosclerosis]." Deutsche Medizinische Wochenschrift (1946), vol. 126, no. 8, 2001, pp. 193-7.
Temelkova-Kurktschiev T, Fischer S, Koehler C, et al. [Intima-media thickness in healthy probands without risk factors for arteriosclerosis]. Dtsch Med Wochenschr. 2001;126(8):193-7.
Temelkova-Kurktschiev, T., Fischer, S., Koehler, C., Mennicken, G., Henkel, E., & Hanefeld, M. (2001). [Intima-media thickness in healthy probands without risk factors for arteriosclerosis]. Deutsche Medizinische Wochenschrift (1946), 126(8), 193-7.
Temelkova-Kurktschiev T, et al. [Intima-media Thickness in Healthy Probands Without Risk Factors for Arteriosclerosis]. Dtsch Med Wochenschr. 2001 Feb 23;126(8):193-7. PubMed PMID: 11256022.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Intima-media thickness in healthy probands without risk factors for arteriosclerosis]. AU - Temelkova-Kurktschiev,T, AU - Fischer,S, AU - Koehler,C, AU - Mennicken,G, AU - Henkel,E, AU - Hanefeld,M, PY - 2001/3/21/pubmed PY - 2001/4/6/medline PY - 2001/3/21/entrez SP - 193 EP - 7 JF - Deutsche medizinische Wochenschrift (1946) JO - Dtsch Med Wochenschr VL - 126 IS - 8 N2 - BACKGROUND AND OBJECTIVE: Ultrasound examination of the intima-media thickness (IMT) is a well accepted, highly reproducible method for the evaluation of early atherosclerosis. However, for the exact interpretation of these measurements reference values for IMT should be determined. The present work provides for the first time normal values for IMT of the common carotid artery and the arteries of the lower limbs (common femoral, superficial and popliteal arteries) in a German population of healthy subjects without risk factors. SUBJECTS AND METHODS: A total of 112 subjects (50 men, 62 women), aged 40 to 70, were examined, according to the following inclusion criteria: no diabetes or marked elevation of postprandial plasma glucose; non-smokers; no hypertension, obesity, dys/hyperlipidaemia or albuminuria; no history of coronary heart disease, stroke and peripheral arterial occlusion. IMT was measured and standardized by the method of Pignoli. Total cholesterol, triglycerides, HDL-cholesterol, HbA1c, plasma glucose (fasting and postprandial) and albuminuria were examined by routine methods. RESULTS: The mean values of double measurements bilaterally in the distal part of the common carotid artery in men were 0.79 (0.73 ... 0.84) mm (40-54 years) and 0.87 (0.81 ... 0.93) mm (55-70 years). In women the values were: -0.70 (0.67 ... 0.75) mm and 0.82 (0.75 ... 0.90) mm, resp. In the group aged 40-54 years the men showed significantly higher IMT of all examined vessels in comparison to the women. In the group aged 55-70 years somewhat higher IMT of the common carotid artery and significantly higher IMT of the arteries of the lower extremity were observed in men. In multivariate analysis age was found to be a significant determinant of IMT of all examined vessels. CONCLUSION: Intima-media thickening of the common carotid artery in men aged 40-70 years is to be accepted if a single measurement of IMT exceeds > or = 1 mm. For women, aged 40-54 years, IMT is defined as pathological if one IMT is above 0.85 mm, and for those aged 55-70 years if IMT exceeds 1 mm. SN - 0012-0472 UR - https://www.unboundmedicine.com/medline/citation/11256022/[Intima_media_thickness_in_healthy_probands_without_risk_factors_for_arteriosclerosis]_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2001-11317 DB - PRIME DP - Unbound Medicine ER -