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Untoward effects associated with practolol administration: oculomucocutaneous syndrome.

Abstract

Keratoconjunctivitis sicca, conjunctival scarring, fibrosis, metaplasia, and shrinkage developed in 27 patients as an adverse reaction to practolol. Rashes, nasal and mucosal ulceration, fibrous or plastic peritonitis, pleurisy, cochlear damage, and secretory otitis media also occurred in some cases. Three patients suffered profound visual loss though most retained good vision. Symptoms and signs improved on withdrawal of the drug, but reduction of tear secretion persisted in most patients.

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  • Authors

    Source

    British medical journal 1:5958 1975 Mar 15 pg 595-8

    MeSH

    Adult
    Aged
    Blindness
    Cochlea
    Conjunctiva
    Ear Diseases
    Eye Diseases
    Female
    Humans
    Keratoconjunctivitis
    Lacrimal Apparatus
    Male
    Metaplasia
    Middle Aged
    Mouth Diseases
    Nose Diseases
    Otitis Media
    Peritonitis
    Pigmentation Disorders
    Pleurisy
    Practolol
    Syndrome
    Uveitis
    Uveomeningoencephalitic Syndrome

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    1125623

    Citation

    * When formatting your citation, note that all book, journal, and database titles should be italicized* Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Untoward effects associated with practolol administration: oculomucocutaneous syndrome. A1 - Wright,P, PY - 1975/3/15/pubmed PY - 1975/3/15/medline PY - 1975/3/15/entrez SP - 595 EP - 8 JF - British medical journal JO - Br Med J VL - 1 IS - 5958 N2 - Keratoconjunctivitis sicca, conjunctival scarring, fibrosis, metaplasia, and shrinkage developed in 27 patients as an adverse reaction to practolol. Rashes, nasal and mucosal ulceration, fibrous or plastic peritonitis, pleurisy, cochlear damage, and secretory otitis media also occurred in some cases. Three patients suffered profound visual loss though most retained good vision. Symptoms and signs improved on withdrawal of the drug, but reduction of tear secretion persisted in most patients. SN - 0007-1447 UR - https://www.unboundmedicine.com/medline/citation/1125623/Untoward_effects_associated_with_practolol_administration:_oculomucocutaneous_syndrome_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/1125623/ DB - PRIME DP - Unbound Medicine ER -