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Effect of different moisturizers on SLS-irritated human skin.
Contact Dermatitis. 2001 Apr; 44(4):229-34.CD

Abstract

Moisturizers are widely used to treat irritant contact dermatitis (ICD). Their use is, however, not well-documented and standardized models for testing skin care products are needed to acquire documentation of their efficacy. The present study was undertaken to evaluate the effect of 6 commonly-used moisturizers on the recovery of irritated human skin. No commercial interests were involved in the study. 36 healthy volunteers had patch tests with SLS 0.5% applied on their forearms/upper arms for 24 h. After irritation of the skin, all volunteers had a moisturizer applied on one forearm/upper arm, respectively, 3 x daily for the following 5 days. The other forearm/upper arm served as an untreated control. Each moisturizer was tested on 12 volunteers and each volunteer tested 2 moisturizers at the same time. Evaluation was done on days 1, 3 and 8 by transepidermal water loss, electrical capacitance, laser Doppler flowmetry, DermaSpectrometry and clinical scoring. All 6 moisturizers were found to accelerate regeneration of the skin barrier function when compared to irritated non-treated skin. The most lipid-rich moisturizers improved barrier restoration more rapidly than the less lipid-rich moisturizers. We suggest this experimental model for further moisturizer efficacy testing.

Authors+Show Affiliations

Department of Dermatology, University of Copenhagen, Gentofte Hospital, Niels Andersensvej 65, 2900 Hellerup, Denmark.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

11260239

Citation

Held, E, et al. "Effect of Different Moisturizers On SLS-irritated Human Skin." Contact Dermatitis, vol. 44, no. 4, 2001, pp. 229-34.
Held E, Lund H, Agner T. Effect of different moisturizers on SLS-irritated human skin. Contact Dermatitis. 2001;44(4):229-34.
Held, E., Lund, H., & Agner, T. (2001). Effect of different moisturizers on SLS-irritated human skin. Contact Dermatitis, 44(4), 229-34.
Held E, Lund H, Agner T. Effect of Different Moisturizers On SLS-irritated Human Skin. Contact Dermatitis. 2001;44(4):229-34. PubMed PMID: 11260239.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of different moisturizers on SLS-irritated human skin. AU - Held,E, AU - Lund,H, AU - Agner,T, PY - 2001/3/22/pubmed PY - 2001/5/22/medline PY - 2001/3/22/entrez SP - 229 EP - 34 JF - Contact dermatitis JO - Contact Dermatitis VL - 44 IS - 4 N2 - Moisturizers are widely used to treat irritant contact dermatitis (ICD). Their use is, however, not well-documented and standardized models for testing skin care products are needed to acquire documentation of their efficacy. The present study was undertaken to evaluate the effect of 6 commonly-used moisturizers on the recovery of irritated human skin. No commercial interests were involved in the study. 36 healthy volunteers had patch tests with SLS 0.5% applied on their forearms/upper arms for 24 h. After irritation of the skin, all volunteers had a moisturizer applied on one forearm/upper arm, respectively, 3 x daily for the following 5 days. The other forearm/upper arm served as an untreated control. Each moisturizer was tested on 12 volunteers and each volunteer tested 2 moisturizers at the same time. Evaluation was done on days 1, 3 and 8 by transepidermal water loss, electrical capacitance, laser Doppler flowmetry, DermaSpectrometry and clinical scoring. All 6 moisturizers were found to accelerate regeneration of the skin barrier function when compared to irritated non-treated skin. The most lipid-rich moisturizers improved barrier restoration more rapidly than the less lipid-rich moisturizers. We suggest this experimental model for further moisturizer efficacy testing. SN - 0105-1873 UR - https://www.unboundmedicine.com/medline/citation/11260239/Effect_of_different_moisturizers_on_SLS_irritated_human_skin_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0105-1873&date=2001&volume=44&issue=4&spage=229 DB - PRIME DP - Unbound Medicine ER -