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Effect of batroxobin against dog heart ischemia/reperfusion injury.
Acta Pharmacol Sin. 2000 Jan; 21(1):70-4.AP

Abstract

AIM

To study the effect of batroxobin(Bat) on dog heart ischemia/reperfusion (I/R) injury.

METHODS

Dog heart I/R injury was induced by occluding the left anterior descending coronary artery for 30 min and restoring blood perfusion for 90 min. Bat was intravenously injected before heart ischemia and 15 min before reperfusion. Plasma creatine kinase (CK), lactate dehydrogenase (LDH), and myocardial malondiaedehyde (MDA) concentrations were measured. The pathologic changes of I/R myocardium were observed.

RESULTS

Bat reduced the mortality rate of I/R dog (I/R group 65.0% vs Bat-I group 30.0% and Bat-II group 28.6%, P < 0.05). Myocytes of I/R heart showed intracellular edema, damaged mitochondria, and concentrated nucleus. Bat decreased these changes. In Bat-I and Bat-II group, plasma CK and LDH level were reduced, the +dp/dtmax and -dp/dtmax at 30 min after ischemia and 90 min after reperfusion were elevated, and left ventricular end dilation pressure (LVEDP) was lowered. The myocardial MDA contents were decreased by 42.3% and 38.1% (P < 0.01) in Bat-I and Bat-II group, respectively.

CONCLUSION

Bat may exert an apparent role against dog heart ischemia/reperfusion injury and improve myocardial function.

Authors+Show Affiliations

Jiang ZS
Institute of Cardiovascular Basic Research, Beijing Medical University, Beijing 100083, China. zsjiang@public.bta.net.cn
Xia CF
No affiliation info available
Tian QP
No affiliation info available
Fu MG
No affiliation info available
Wang XH
No affiliation info available
Pang YZ
No affiliation info available
Tang CS
No affiliation info available
Liu NK
No affiliation info available

MeSH

AnimalsBatroxobinCreatine KinaseDogsFibrinolytic AgentsHeart Function TestsL-Lactate DehydrogenaseMaleMalondialdehydeMyocardial Reperfusion InjuryMyocardium

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11263251

Citation

Jiang, Z S., et al. "Effect of Batroxobin Against Dog Heart Ischemia/reperfusion Injury." Acta Pharmacologica Sinica, vol. 21, no. 1, 2000, pp. 70-4.
Jiang ZS, Xia CF, Tian QP, et al. Effect of batroxobin against dog heart ischemia/reperfusion injury. Acta Pharmacol Sin. 2000;21(1):70-4.
Jiang, Z. S., Xia, C. F., Tian, Q. P., Fu, M. G., Wang, X. H., Pang, Y. Z., Tang, C. S., & Liu, N. K. (2000). Effect of batroxobin against dog heart ischemia/reperfusion injury. Acta Pharmacologica Sinica, 21(1), 70-4.
Jiang ZS, et al. Effect of Batroxobin Against Dog Heart Ischemia/reperfusion Injury. Acta Pharmacol Sin. 2000;21(1):70-4. PubMed PMID: 11263251.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of batroxobin against dog heart ischemia/reperfusion injury. AU - Jiang,Z S, AU - Xia,C F, AU - Tian,Q P, AU - Fu,M G, AU - Wang,X H, AU - Pang,Y Z, AU - Tang,C S, AU - Liu,N K, PY - 2001/3/27/pubmed PY - 2001/5/5/medline PY - 2001/3/27/entrez SP - 70 EP - 4 JF - Acta pharmacologica Sinica JO - Acta Pharmacol Sin VL - 21 IS - 1 N2 - AIM: To study the effect of batroxobin(Bat) on dog heart ischemia/reperfusion (I/R) injury. METHODS: Dog heart I/R injury was induced by occluding the left anterior descending coronary artery for 30 min and restoring blood perfusion for 90 min. Bat was intravenously injected before heart ischemia and 15 min before reperfusion. Plasma creatine kinase (CK), lactate dehydrogenase (LDH), and myocardial malondiaedehyde (MDA) concentrations were measured. The pathologic changes of I/R myocardium were observed. RESULTS: Bat reduced the mortality rate of I/R dog (I/R group 65.0% vs Bat-I group 30.0% and Bat-II group 28.6%, P < 0.05). Myocytes of I/R heart showed intracellular edema, damaged mitochondria, and concentrated nucleus. Bat decreased these changes. In Bat-I and Bat-II group, plasma CK and LDH level were reduced, the +dp/dtmax and -dp/dtmax at 30 min after ischemia and 90 min after reperfusion were elevated, and left ventricular end dilation pressure (LVEDP) was lowered. The myocardial MDA contents were decreased by 42.3% and 38.1% (P < 0.01) in Bat-I and Bat-II group, respectively. CONCLUSION: Bat may exert an apparent role against dog heart ischemia/reperfusion injury and improve myocardial function. SN - 1671-4083 UR - https://www.unboundmedicine.com/medline/citation/11263251/Effect_of_batroxobin_against_dog_heart_ischemia/reperfusion_injury_ DB - PRIME DP - Unbound Medicine ER -