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[A study on enzymatic activities of bronchoalveolar lavage fluid in patients with interstitial lung diseases].
Zhonghua Jie He He Hu Xi Za Zhi. 1998 Feb; 21(2):91-3.ZJ

Abstract

OBJECTIVE

To evaluate the relationship between enzymatic activities in bronchoalveolar lavage fluid(BALF) and interstitial lung diseases(ILDs).

METHOD

Cellular components and levels of superoxide dismutase (SOD), glutathione peroxidase(GSH-PX), angiotensin converting enzyme(ACE) and lactate dehydrogenase(LDH) in BALF in 30 cases of ILDs: including 18 patients with idiopathic pulmonary fibrosis (IPF) and 12 patients with sarcoidosis (Sarc) and 9 healthy controls were determined.

RESULT

(1) The levels of BALF-SOD, GSH-PX were significantly decreased(P < 0.01), and BALF-ACE, LDH were markedly increased (P < 0.05) in patients with IPF, and BALF-ACE were also increased in patients with Sarc(P < 0.05); (2) There were good correlation between ACE and percentage of lymphocyte (r1 = 0.6574, P < 0.05), and ratio of CD4+/CD8+ (r2 = 0.9544, P < 0.001) in BALF of Sarc group.

CONCLUSION

Determining enzymatic activities could be helpful to study pathogenesis and diagnosis of ILDs, BALF-ACE may be as a good marker of disease activity of Sarcoidosis.

Authors+Show Affiliations

Affiliated ZhongShan Hospital of Shanghai Medical University, Shanghai 200032.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

11263392

Citation

Zheng, J, et al. "[A Study On Enzymatic Activities of Bronchoalveolar Lavage Fluid in Patients With Interstitial Lung Diseases]." Zhonghua Jie He He Hu Xi Za Zhi = Zhonghua Jiehe He Huxi Zazhi = Chinese Journal of Tuberculosis and Respiratory Diseases, vol. 21, no. 2, 1998, pp. 91-3.
Zheng J, Jia Y, Zhou K. [A study on enzymatic activities of bronchoalveolar lavage fluid in patients with interstitial lung diseases]. Zhonghua Jie He He Hu Xi Za Zhi. 1998;21(2):91-3.
Zheng, J., Jia, Y., & Zhou, K. (1998). [A study on enzymatic activities of bronchoalveolar lavage fluid in patients with interstitial lung diseases]. Zhonghua Jie He He Hu Xi Za Zhi = Zhonghua Jiehe He Huxi Zazhi = Chinese Journal of Tuberculosis and Respiratory Diseases, 21(2), 91-3.
Zheng J, Jia Y, Zhou K. [A Study On Enzymatic Activities of Bronchoalveolar Lavage Fluid in Patients With Interstitial Lung Diseases]. Zhonghua Jie He He Hu Xi Za Zhi. 1998;21(2):91-3. PubMed PMID: 11263392.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [A study on enzymatic activities of bronchoalveolar lavage fluid in patients with interstitial lung diseases]. AU - Zheng,J, AU - Jia,Y, AU - Zhou,K, PY - 2001/3/27/pubmed PY - 2001/5/5/medline PY - 2001/3/27/entrez SP - 91 EP - 3 JF - Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases JO - Zhonghua Jie He He Hu Xi Za Zhi VL - 21 IS - 2 N2 - OBJECTIVE: To evaluate the relationship between enzymatic activities in bronchoalveolar lavage fluid(BALF) and interstitial lung diseases(ILDs). METHOD: Cellular components and levels of superoxide dismutase (SOD), glutathione peroxidase(GSH-PX), angiotensin converting enzyme(ACE) and lactate dehydrogenase(LDH) in BALF in 30 cases of ILDs: including 18 patients with idiopathic pulmonary fibrosis (IPF) and 12 patients with sarcoidosis (Sarc) and 9 healthy controls were determined. RESULT: (1) The levels of BALF-SOD, GSH-PX were significantly decreased(P < 0.01), and BALF-ACE, LDH were markedly increased (P < 0.05) in patients with IPF, and BALF-ACE were also increased in patients with Sarc(P < 0.05); (2) There were good correlation between ACE and percentage of lymphocyte (r1 = 0.6574, P < 0.05), and ratio of CD4+/CD8+ (r2 = 0.9544, P < 0.001) in BALF of Sarc group. CONCLUSION: Determining enzymatic activities could be helpful to study pathogenesis and diagnosis of ILDs, BALF-ACE may be as a good marker of disease activity of Sarcoidosis. SN - 1001-0939 UR - https://www.unboundmedicine.com/medline/citation/11263392/[A_study_on_enzymatic_activities_of_bronchoalveolar_lavage_fluid_in_patients_with_interstitial_lung_diseases]_ L2 - https://medlineplus.gov/pulmonaryfibrosis.html DB - PRIME DP - Unbound Medicine ER -