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Studies on aging piroxicam-polyvinylpyrrolidone solid dispersions.
Pharmazie. 2001 Mar; 56(3):227-30.P

Abstract

The stabilities of X-ray amorphous solid dispersions of piroxicam and polyvinylpyrrolidone (PVP) K-17 and PVP K-30 (1:5 and 1:4), respectively, were investigated after storage for 12 months. X-ray diffraction showed that in the aged solid dispersions piroxicam remained in the amorphous state. Fourier transform infrared (FTIR) spectroscopy indicated that the interactions between drug and PVP in aged solid dispersions are similar to those in freshly prepared samples. The dissolution rates of the X-ray amorphous solid dispersions during storage for 12 months at 45 degrees C and ambient temperature were examined. Very minor decreases in dissolution rates of aged solid dispersions were found which might be due to the coarsening of the particles. Dissolutions of these amorphous solid dispersions after aging for 12 months still showed an about 40-fold increase in dissolution in 5 min compared to pure drug.

Authors+Show Affiliations

Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Songkhla, Thailand. isuthima@ratree.psu.ac.thNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11265589

Citation

Ingkatawornwong, S, et al. "Studies On Aging Piroxicam-polyvinylpyrrolidone Solid Dispersions." Die Pharmazie, vol. 56, no. 3, 2001, pp. 227-30.
Ingkatawornwong S, Kaewnopparat N, Tantishaiyakul V. Studies on aging piroxicam-polyvinylpyrrolidone solid dispersions. Pharmazie. 2001;56(3):227-30.
Ingkatawornwong, S., Kaewnopparat, N., & Tantishaiyakul, V. (2001). Studies on aging piroxicam-polyvinylpyrrolidone solid dispersions. Die Pharmazie, 56(3), 227-30.
Ingkatawornwong S, Kaewnopparat N, Tantishaiyakul V. Studies On Aging Piroxicam-polyvinylpyrrolidone Solid Dispersions. Pharmazie. 2001;56(3):227-30. PubMed PMID: 11265589.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Studies on aging piroxicam-polyvinylpyrrolidone solid dispersions. AU - Ingkatawornwong,S, AU - Kaewnopparat,N, AU - Tantishaiyakul,V, PY - 2001/3/27/pubmed PY - 2001/5/5/medline PY - 2001/3/27/entrez SP - 227 EP - 30 JF - Die Pharmazie JO - Pharmazie VL - 56 IS - 3 N2 - The stabilities of X-ray amorphous solid dispersions of piroxicam and polyvinylpyrrolidone (PVP) K-17 and PVP K-30 (1:5 and 1:4), respectively, were investigated after storage for 12 months. X-ray diffraction showed that in the aged solid dispersions piroxicam remained in the amorphous state. Fourier transform infrared (FTIR) spectroscopy indicated that the interactions between drug and PVP in aged solid dispersions are similar to those in freshly prepared samples. The dissolution rates of the X-ray amorphous solid dispersions during storage for 12 months at 45 degrees C and ambient temperature were examined. Very minor decreases in dissolution rates of aged solid dispersions were found which might be due to the coarsening of the particles. Dissolutions of these amorphous solid dispersions after aging for 12 months still showed an about 40-fold increase in dissolution in 5 min compared to pure drug. SN - 0031-7144 UR - https://www.unboundmedicine.com/medline/citation/11265589/Studies_on_aging_piroxicam_polyvinylpyrrolidone_solid_dispersions_ DB - PRIME DP - Unbound Medicine ER -