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Antimalarial chemoprophylaxis in infants and children.
Paediatr Drugs. 2001; 3(2):113-21.PD

Abstract

The evolving patterns of drug resistance in malaria parasites and changes in recommendations for malaria prevention present a challenge to physicians who advise travellers on chemoprophylaxis. Because compliance with personal protection measures is usually low, children should receive appropriate chemoprophylaxis, including breast-fed infants who are not protected through maternal chemoprophylaxis. For travel to areas where chloroquine resistance has not yet been reported (i.e. parts of Central America, the Caribbean and parts of the Middle East), chloroquine alone is sufficient for antimalarial prophylaxis. Mefloquine is the drug of choice for chemoprophylaxis in areas with chloroquine-resistant Plasmodium falciparum, and can be given to infants and young children. The combination of chloroquine and proguanil is well tolerated in children but is much less effective against drug-resistant malaria. Further research is needed to determine the best dosage regimen for antimalarial drugs used for chemoprophylaxis in children.

Authors+Show Affiliations

Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Diseases Control and Prevention, Atlanta, Georgia 30341, USA.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

11269638

Citation

Kramer, M H., and H O. Lobel. "Antimalarial Chemoprophylaxis in Infants and Children." Paediatric Drugs, vol. 3, no. 2, 2001, pp. 113-21.
Kramer MH, Lobel HO. Antimalarial chemoprophylaxis in infants and children. Paediatr Drugs. 2001;3(2):113-21.
Kramer, M. H., & Lobel, H. O. (2001). Antimalarial chemoprophylaxis in infants and children. Paediatric Drugs, 3(2), 113-21.
Kramer MH, Lobel HO. Antimalarial Chemoprophylaxis in Infants and Children. Paediatr Drugs. 2001;3(2):113-21. PubMed PMID: 11269638.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antimalarial chemoprophylaxis in infants and children. AU - Kramer,M H, AU - Lobel,H O, PY - 2001/3/28/pubmed PY - 2001/5/22/medline PY - 2001/3/28/entrez SP - 113 EP - 21 JF - Paediatric drugs JO - Paediatr Drugs VL - 3 IS - 2 N2 - The evolving patterns of drug resistance in malaria parasites and changes in recommendations for malaria prevention present a challenge to physicians who advise travellers on chemoprophylaxis. Because compliance with personal protection measures is usually low, children should receive appropriate chemoprophylaxis, including breast-fed infants who are not protected through maternal chemoprophylaxis. For travel to areas where chloroquine resistance has not yet been reported (i.e. parts of Central America, the Caribbean and parts of the Middle East), chloroquine alone is sufficient for antimalarial prophylaxis. Mefloquine is the drug of choice for chemoprophylaxis in areas with chloroquine-resistant Plasmodium falciparum, and can be given to infants and young children. The combination of chloroquine and proguanil is well tolerated in children but is much less effective against drug-resistant malaria. Further research is needed to determine the best dosage regimen for antimalarial drugs used for chemoprophylaxis in children. SN - 1174-5878 UR - https://www.unboundmedicine.com/medline/citation/11269638/Antimalarial_chemoprophylaxis_in_infants_and_children_ DB - PRIME DP - Unbound Medicine ER -