Tags

Type your tag names separated by a space and hit enter

Possible implications of arginase and diamine oxidase in prostatic carcinoma.
Cancer Detect Prev. 2001; 25(1):76-9.CD

Abstract

Polyamine metabolism in prostatic tissue, which may give rise to prostatic hyperplasia by inducing cell proliferation, is controlled primarily by two enzymes: arginase and diamine oxidase (DAO). Arginase catalyzes the synthesis of ornithine, the precursor for polyamines from arginine, whereas DAO catalyzes the oxidation of diamines. such as spermine and spermidine, to a much less active compound called putrescine. In this study, we evaluated arginase and DAO activities in prostate tissues of 50 patients with benign prostatic hyperplasia and in 23 patients with prostatic carcinoma. Both DAO and arginase activities were found to be elevated in cancer tissues as compared to benign prostatic hyperplasia (fivefold and twofold, respectively; P < .001). A strong inverse correlation between arginase and DAO activities was observed in those in the cancer group (r = -0.65; P < .001). Gleason grades of prostatic carcinomas were well correlated with both arginase and DAO activities. Results suggest that DAO and arginase might play an essential role in the mechanism of prostatic disease process by modulating polyamine levels.

Authors+Show Affiliations

Düzen Laboratories Group, Ankara University, Turkey.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11270424

Citation

Keskinege, A, et al. "Possible Implications of Arginase and Diamine Oxidase in Prostatic Carcinoma." Cancer Detection and Prevention, vol. 25, no. 1, 2001, pp. 76-9.
Keskinege A, Elgün S, Yilmaz E. Possible implications of arginase and diamine oxidase in prostatic carcinoma. Cancer Detect Prev. 2001;25(1):76-9.
Keskinege, A., Elgün, S., & Yilmaz, E. (2001). Possible implications of arginase and diamine oxidase in prostatic carcinoma. Cancer Detection and Prevention, 25(1), 76-9.
Keskinege A, Elgün S, Yilmaz E. Possible Implications of Arginase and Diamine Oxidase in Prostatic Carcinoma. Cancer Detect Prev. 2001;25(1):76-9. PubMed PMID: 11270424.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Possible implications of arginase and diamine oxidase in prostatic carcinoma. AU - Keskinege,A, AU - Elgün,S, AU - Yilmaz,E, PY - 2001/3/29/pubmed PY - 2001/6/23/medline PY - 2001/3/29/entrez SP - 76 EP - 9 JF - Cancer detection and prevention JO - Cancer Detect Prev VL - 25 IS - 1 N2 - Polyamine metabolism in prostatic tissue, which may give rise to prostatic hyperplasia by inducing cell proliferation, is controlled primarily by two enzymes: arginase and diamine oxidase (DAO). Arginase catalyzes the synthesis of ornithine, the precursor for polyamines from arginine, whereas DAO catalyzes the oxidation of diamines. such as spermine and spermidine, to a much less active compound called putrescine. In this study, we evaluated arginase and DAO activities in prostate tissues of 50 patients with benign prostatic hyperplasia and in 23 patients with prostatic carcinoma. Both DAO and arginase activities were found to be elevated in cancer tissues as compared to benign prostatic hyperplasia (fivefold and twofold, respectively; P < .001). A strong inverse correlation between arginase and DAO activities was observed in those in the cancer group (r = -0.65; P < .001). Gleason grades of prostatic carcinomas were well correlated with both arginase and DAO activities. Results suggest that DAO and arginase might play an essential role in the mechanism of prostatic disease process by modulating polyamine levels. SN - 0361-090X UR - https://www.unboundmedicine.com/medline/citation/11270424/Possible_implications_of_arginase_and_diamine_oxidase_in_prostatic_carcinoma_ L2 - https://medlineplus.gov/enlargedprostatebph.html DB - PRIME DP - Unbound Medicine ER -