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Progression of large artery structural and functional alterations in Type I diabetes.
Diabetologia. 2001 Feb; 44(2):203-8.D

Abstract

AIMS/HYPOTHESIS

Type I (insulin-dependent) diabetes mellitus is accompanied by reduced arterial distensibility and increased arterial wall thickness even in normotensive subjects with no micro-macrovascular complications. It is not known whether, and how fast, these subclinical markers of vascular damage develop over time.

METHODS

We measured arterial wall distensibility in radial, common carotid artery and abdominal aorta in 60 normotensive patients (aged 35.0 +/- 1.2 years, means +/- SE) with Type I diabetes with no microvascular or macrovascular complications and in 20 healthy control subjects matched for age. Arterial distensibility was determined by continuous measurements of arterial diameter through echotracking techniques and by using either the Langewouters (radial artery) or the Reneman formula (carotid artery and aorta). The same echotracking techniques allowed us to ascertain the radial and carotid artery wall thickness. Data were collected before and after 23 +/- 1 months.

RESULTS

In the first study, carotid artery distensibility was similar but radial artey and aortic distensibility was less (p < 0.01) in patients with diabetes than in control subjects (-39 % and 25 % respectively). This was accompanied by an increase (p < 0.01) in both radial (42 %) and carotid artery wall thickness (46 %). After 23 +/- 1 months diabetic subjects showed a further reduction in arterial distensibility (radial-12 %, p < 0.05; carotid-8 %, NS; aorta-20% p < 0.05) and an increase in arterial wall thickness (radial + 15 %; carotid 14%, p < 0,05). No change in distensibility and wall thickness values occurred in control subjects.

CONCLUSION/INTERPRETATION

The early reduction in arterial distensibility and increase in arterial wall thickness characterizing uncomplicated normotensive Type I diabetes patients shows a measurable worsening over the short term.

Authors+Show Affiliations

Internal Medicine, Università of Milan-Bicocca, S.Gerardo Hospital, Monza, Milano, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11270677

Citation

Giannattasio, C, et al. "Progression of Large Artery Structural and Functional Alterations in Type I Diabetes." Diabetologia, vol. 44, no. 2, 2001, pp. 203-8.
Giannattasio C, Failla M, Grappiolo A, et al. Progression of large artery structural and functional alterations in Type I diabetes. Diabetologia. 2001;44(2):203-8.
Giannattasio, C., Failla, M., Grappiolo, A., Gamba, P. L., Paleari, F., & Mancia, G. (2001). Progression of large artery structural and functional alterations in Type I diabetes. Diabetologia, 44(2), 203-8.
Giannattasio C, et al. Progression of Large Artery Structural and Functional Alterations in Type I Diabetes. Diabetologia. 2001;44(2):203-8. PubMed PMID: 11270677.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Progression of large artery structural and functional alterations in Type I diabetes. AU - Giannattasio,C, AU - Failla,M, AU - Grappiolo,A, AU - Gamba,P L, AU - Paleari,F, AU - Mancia,G, PY - 2001/3/29/pubmed PY - 2001/6/2/medline PY - 2001/3/29/entrez SP - 203 EP - 8 JF - Diabetologia JO - Diabetologia VL - 44 IS - 2 N2 - AIMS/HYPOTHESIS: Type I (insulin-dependent) diabetes mellitus is accompanied by reduced arterial distensibility and increased arterial wall thickness even in normotensive subjects with no micro-macrovascular complications. It is not known whether, and how fast, these subclinical markers of vascular damage develop over time. METHODS: We measured arterial wall distensibility in radial, common carotid artery and abdominal aorta in 60 normotensive patients (aged 35.0 +/- 1.2 years, means +/- SE) with Type I diabetes with no microvascular or macrovascular complications and in 20 healthy control subjects matched for age. Arterial distensibility was determined by continuous measurements of arterial diameter through echotracking techniques and by using either the Langewouters (radial artery) or the Reneman formula (carotid artery and aorta). The same echotracking techniques allowed us to ascertain the radial and carotid artery wall thickness. Data were collected before and after 23 +/- 1 months. RESULTS: In the first study, carotid artery distensibility was similar but radial artey and aortic distensibility was less (p < 0.01) in patients with diabetes than in control subjects (-39 % and 25 % respectively). This was accompanied by an increase (p < 0.01) in both radial (42 %) and carotid artery wall thickness (46 %). After 23 +/- 1 months diabetic subjects showed a further reduction in arterial distensibility (radial-12 %, p < 0.05; carotid-8 %, NS; aorta-20% p < 0.05) and an increase in arterial wall thickness (radial + 15 %; carotid 14%, p < 0,05). No change in distensibility and wall thickness values occurred in control subjects. CONCLUSION/INTERPRETATION: The early reduction in arterial distensibility and increase in arterial wall thickness characterizing uncomplicated normotensive Type I diabetes patients shows a measurable worsening over the short term. SN - 0012-186X UR - https://www.unboundmedicine.com/medline/citation/11270677/Progression_of_large_artery_structural_and_functional_alterations_in_Type_I_diabetes_ L2 - https://doi.org/10.1007/s001250051600 DB - PRIME DP - Unbound Medicine ER -